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Saito S, Lin YC, Murayama Y, et al. Retracted article: In vitro derivation of mammalian germ cells from stem cells and their potential therapeutic application. Cell Mol Life Sci. 2015;72(23):4545-60doi: 10.1007/s00018-015-2020-1.
Saito, S., Lin, Y. C., Murayama, Y., Nakamura, Y., Eckner, R., Niemann, H., & Yokoyama, K. K. (2015). Retracted article: In vitro derivation of mammalian germ cells from stem cells and their potential therapeutic application. Cellular and molecular life sciences : CMLS, 72(23), 4545-60. https://doi.org/10.1007/s00018-015-2020-1
Saito, Shigeo, et al. "Retracted article: In vitro derivation of mammalian germ cells from stem cells and their potential therapeutic application." Cellular and molecular life sciences : CMLS vol. 72,23 (2015): 4545-60. doi: https://doi.org/10.1007/s00018-015-2020-1
Saito S, Lin YC, Murayama Y, Nakamura Y, Eckner R, Niemann H, Yokoyama KK. Retracted article: In vitro derivation of mammalian germ cells from stem cells and their potential therapeutic application. Cell Mol Life Sci. 2015 Dec;72(23):4545-60. doi: 10.1007/s00018-015-2020-1. Epub 2015 Oct 06. PMID: 26439925; PMCID: PMC4628088.
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Cell Mol Life Sci. 2015 Dec;72(23):4545-60. doi: 10.1007/s00018-015-2020-1. Epub 2015 Oct 06.

Retracted article: In vitro derivation of mammalian germ cells from stem cells and their potential therapeutic application.

Cellular and molecular life sciences : CMLS

Shigeo Saito, Ying-Chu Lin, Yoshinobu Murayama, Yukio Nakamura, Richard Eckner, Heiner Niemann, Kazunari K Yokoyama

Affiliations

  1. Saito Laboratory of Cell Technology, Yaita, Tochigi, 329-1571, Japan. [email protected].
  2. SPK Co., Ltd., Aizuwakamatsu, Fukushima, 965-0025, Japan. [email protected].
  3. College of Engineering, Nihon University, Koriyama, Fukushima, 963-8642, Japan. [email protected].
  4. School of Dentistry, College of Dental Medicine, Kaoshiung Medical University, 100 Shin-Chuan 1st Road, Kaohsiung, 807, Taiwan.
  5. College of Engineering, Nihon University, Koriyama, Fukushima, 963-8642, Japan.
  6. Cell Engineering Division, RIKEN BioResource Center, Tsukuba, 3050074, Japan.
  7. Department of Biochemistry and Molecular Biology, Rutgers New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, 07101, USA.
  8. Institute of Farm Animal Genetics, Friedrich-Löffler-Institut, Mariensee, 31535, Neustadt, Germany. [email protected].
  9. Graduate Institute of Medicine, Center of Stem Cell Research, Center of Environmental Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Rd, San Ming District, Kaohsiung, 807, Taiwan. [email protected].
  10. Faculty of Science and Engineering, Tokushima Bunri University, Sanuki, 763-2193, Japan. [email protected].
  11. Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan. [email protected].

PMID: 26439925 PMCID: PMC4628088 DOI: 10.1007/s00018-015-2020-1

Abstract

Pluripotent stem cells (PSCs) are a unique type of cells because they exhibit the characteristics of self-renewal and pluripotency. PSCs may be induced to differentiate into any cell type, even male and female germ cells, suggesting their potential as novel cell-based therapeutic treatment for infertility problems. Spermatogenesis is an intricate biological process that starts from self-renewal of spermatogonial stem cells (SSCs) and leads to differentiated haploid spermatozoa. Errors at any stage in spermatogenesis may result in male infertility. During the past decade, much progress has been made in the derivation of male germ cells from various types of progenitor stem cells. Currently, there are two main approaches for the derivation of functional germ cells from PSCs, either the induction of in vitro differentiation to produce haploid cell products, or combination of in vitro differentiation and in vivo transplantation. The production of mature and fertile spermatozoa from stem cells might provide an unlimited source of autologous gametes for treatment of male infertility. Here, we discuss the current state of the art regarding the differentiation potential of SSCs, embryonic stem cells, and induced pluripotent stem cells to produce functional male germ cells. We also discuss the possible use of livestock-derived PSCs as a novel option for animal reproduction and infertility treatment.

Keywords: Animal reproduction; Embryonic stem cells; Gametes; Germ cells; Primordial germ cells; Spermatogonial stem cells; Sterility; Therapeutic use

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