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Zuloaga DG, Iancu OD, Weber S, et al. Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure. Front Neurosci. 2015;9:326doi: 10.3389/fnins.2015.00326.
Zuloaga, D. G., Iancu, O. D., Weber, S., Etzel, D., Marzulla, T., Stewart, B., Allen, C. N., & Raber, J. (2015). Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure. Frontiers in neuroscience, 9326. https://doi.org/10.3389/fnins.2015.00326
Zuloaga, Damian G, et al. "Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure." Frontiers in neuroscience vol. 9 (2015): 326. doi: https://doi.org/10.3389/fnins.2015.00326
Zuloaga DG, Iancu OD, Weber S, Etzel D, Marzulla T, Stewart B, Allen CN, Raber J. Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure. Front Neurosci. 2015 Sep 23;9:326. doi: 10.3389/fnins.2015.00326. eCollection 2015. PMID: 26441501; PMCID: PMC4585047.
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Front Neurosci. 2015 Sep 23;9:326. doi: 10.3389/fnins.2015.00326. eCollection 2015.

Enhanced functional connectivity involving the ventromedial hypothalamus following methamphetamine exposure.

Frontiers in neuroscience

Damian G Zuloaga, Ovidiu D Iancu, Sydney Weber, Desiree Etzel, Tessa Marzulla, Blair Stewart, Charles N Allen, Jacob Raber

Affiliations

  1. Department of Behavioral Neuroscience, Oregon Health & Science University Portland Portland, OR, USA ; Department of Psychology, University at Albany Albany, NY, USA.
  2. Department of Behavioral Neuroscience, Oregon Health & Science University Portland Portland, OR, USA.
  3. Department of Behavioral Neuroscience, Oregon Health & Science University Portland Portland, OR, USA ; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University Portland Portland, OR, USA.
  4. Department of Behavioral Neuroscience, Oregon Health & Science University Portland Portland, OR, USA ; Department of Neurology, Oregon Health & Science University Portland Portland, OR, USA ; Department of Radiation Medicine, Oregon Health & Science University Portland Portland, OR, USA ; Division of Neuroscience, ONPRC, Oregon Health & Science University Portland Portland, OR, USA.

PMID: 26441501 PMCID: PMC4585047 DOI: 10.3389/fnins.2015.00326

Abstract

Methamphetamine (MA) consumption causes disruption of many biological rhythms including the sleep-wake cycle. This circadian effect is seen shortly following MA exposure and later in life following developmental MA exposure. MA phase shifts, entrains the circadian clock and can also alter the entraining effect of light by currently unknown mechanisms. We analyzed and compared immunoreactivity of the immediate early gene c-Fos, a marker of neuronal activity, to assess neuronal activation 2 h following MA exposure in the light and dark phases. We used network analyses of correlation patterns derived from global brain immunoreactivity patterns of c-Fos, to infer functional connectivity between brain regions. There were five distinct patterns of neuronal activation. In several brain areas, neuronal activation following exposure to MA was stronger in the light than the dark phase, highlighting the importance of considering circadian periods of increased effects of MA in defining experimental conditions and understanding the mechanisms underlying detrimental effects of MA exposure to brain function. Functional connectivity between the ventromedial hypothalamus (VMH) and other brain areas, including the paraventricular nucleus of the hypothalamus and basolateral and medial amygdala, was enhanced following MA exposure, suggesting a role for the VMH in the effects of MA on the brain.

Keywords: activation; dark phase; functional connectivity; light phase; methamphetamine

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