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de la Fuente V, Federman N, Zalcman G, et al. NF-κB transcription factor role in consolidation and reconsolidation of persistent memories. Front Mol Neurosci. 2015;8:50doi: 10.3389/fnmol.2015.00050.
de la Fuente, V., Federman, N., Zalcman, G., Salles, A., Freudenthal, R., & Romano, A. (2015). NF-κB transcription factor role in consolidation and reconsolidation of persistent memories. Frontiers in molecular neuroscience, 850. https://doi.org/10.3389/fnmol.2015.00050
de la Fuente, Verónica, et al. "NF-κB transcription factor role in consolidation and reconsolidation of persistent memories." Frontiers in molecular neuroscience vol. 8 (2015): 50. doi: https://doi.org/10.3389/fnmol.2015.00050
de la Fuente V, Federman N, Zalcman G, Salles A, Freudenthal R, Romano A. NF-κB transcription factor role in consolidation and reconsolidation of persistent memories. Front Mol Neurosci. 2015 Sep 09;8:50. doi: 10.3389/fnmol.2015.00050. eCollection 2015. PMID: 26441513; PMCID: PMC4563083.
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Front Mol Neurosci. 2015 Sep 09;8:50. doi: 10.3389/fnmol.2015.00050. eCollection 2015.

NF-κB transcription factor role in consolidation and reconsolidation of persistent memories.

Frontiers in molecular neuroscience

Verónica de la Fuente, Noel Federman, Gisela Zalcman, Angeles Salles, Ramiro Freudenthal, Arturo Romano

Affiliations

  1. Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE, UBA-CONICET), Universidad de Buenos Aires, Ciudad Universitaria Buenos Aires, Argentina.

PMID: 26441513 PMCID: PMC4563083 DOI: 10.3389/fnmol.2015.00050

Abstract

Transcriptional regulation is an important molecular process required for long-term neural plasticity and long-term memory (LTM) formation. Thus, one main interest in molecular neuroscience in the last decades has been the identification of transcription factors that are involved in memory processes. Among them, the nuclear factor κB (NF-κB) family of transcription factors has gained interest due to a significant body of evidence that supports a key role of these proteins in synaptic plasticity and memory. In recent years, the interest was particularly reinforced because NF-κB was characterized as an important regulator of synaptogenesis. This function may be explained by its participation in synapse to nucleus communication, as well as a possible local role at the synapse. This review provides an overview of experimental work obtained in the last years, showing the essential role of this transcription factor in memory processes in different learning tasks in mammals. We focus the review on the consolidation and reconsolidation memory phases as well as on the regulation of immediate-early and late genes by epigenetic mechanisms that determine enduring forms of memories.

Keywords: NF-κB; consolidation; memory; reconsolidation; transcription factors

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