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Oberland S, Ackels T, Gaab S, et al. CD36 is involved in oleic acid detection by the murine olfactory system. Front Cell Neurosci. 2015;9:366doi: 10.3389/fncel.2015.00366.
Oberland, S., Ackels, T., Gaab, S., Pelz, T., Spehr, J., Spehr, M., & Neuhaus, E. M. (2015). CD36 is involved in oleic acid detection by the murine olfactory system. Frontiers in cellular neuroscience, 9366. https://doi.org/10.3389/fncel.2015.00366
Oberland, Sonja, et al. "CD36 is involved in oleic acid detection by the murine olfactory system." Frontiers in cellular neuroscience vol. 9 (2015): 366. doi: https://doi.org/10.3389/fncel.2015.00366
Oberland S, Ackels T, Gaab S, Pelz T, Spehr J, Spehr M, Neuhaus EM. CD36 is involved in oleic acid detection by the murine olfactory system. Front Cell Neurosci. 2015 Sep 16;9:366. doi: 10.3389/fncel.2015.00366. eCollection 2015. PMID: 26441537; PMCID: PMC4584952.
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Front Cell Neurosci. 2015 Sep 16;9:366. doi: 10.3389/fncel.2015.00366. eCollection 2015.

CD36 is involved in oleic acid detection by the murine olfactory system.

Frontiers in cellular neuroscience

Sonja Oberland, Tobias Ackels, Stefanie Gaab, Thomas Pelz, Jennifer Spehr, Marc Spehr, Eva M Neuhaus

Affiliations

  1. Pharmacology and Toxicology, University Hospital Jena, Friedrich-Schiller-University Jena Jena, Germany ; Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin Berlin, Germany ; Freie Universität-Berlin, Fachbereich Biologie, Chemie und Pharmazie Berlin, Germany.
  2. Department of Chemosensation, Institute for Biology II, RWTH Aachen University Aachen, Germany.
  3. Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin Berlin, Germany.
  4. Pharmacology and Toxicology, University Hospital Jena, Friedrich-Schiller-University Jena Jena, Germany ; Cluster of Excellence NeuroCure, Charité-Universitätsmedizin Berlin Berlin, Germany.

PMID: 26441537 PMCID: PMC4584952 DOI: 10.3389/fncel.2015.00366

Abstract

Olfactory signals influence food intake in a variety of species. To maximize the chances of finding a source of calories, an animal's preference for fatty foods and triglycerides already becomes apparent during olfactory food search behavior. However, the molecular identity of both receptors and ligands mediating olfactory-dependent fatty acid recognition are, so far, undescribed. We here describe that a subset of olfactory sensory neurons expresses the fatty acid receptor CD36 and demonstrate a receptor-like localization of CD36 in olfactory cilia by STED microscopy. CD36-positive olfactory neurons share olfaction-specific transduction elements and project to numerous glomeruli in the ventral olfactory bulb. In accordance with the described roles of CD36 as fatty acid receptor or co-receptor in other sensory systems, the number of olfactory neurons responding to oleic acid, a major milk component, in Ca(2+) imaging experiments is drastically reduced in young CD36 knock-out mice. Strikingly, we also observe marked age-dependent changes in CD36 localization, which is prominently present in the ciliary compartment only during the suckling period. Our results support the involvement of CD36 in fatty acid detection by the mammalian olfactory system.

Keywords: CD36; Ca2+ imaging; STED; fatty acid; microscopy; olfaction; olfactory receptor; signal transduction

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