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Oncoimmunology. 2015 Apr 01;4(10):e1022301. doi: 10.1080/2162402X.2015.1022301. eCollection 2015 Oct.

Progressive loss of anti-HER2 CD4.

Oncoimmunology

Jashodeep Datta, Cinthia Rosemblit, Erik Berk, Lori Showalter, Prachi Namjoshi, Rosemarie Mick, Kathreen P Lee, Andrew M Brod, Rachel L Yang, Rachel R Kelz, Elizabeth Fitzpatrick, Clifford Hoyt, Michael D Feldman, Paul J Zhang, Shuwen Xu, Gary K Koski, Brian J Czerniecki

Affiliations

  1. Department of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
  2. Department of Biological Sciences; Kent State University ; Kent, OH USA.
  3. Department of Epidemiology and Biostatistics; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
  4. Department of Surgery; Stanford University Hospital and Clinics ; Palo Alto, CA USA.
  5. Life Sciences & Technology; PerkinElmer Inc. ; Hopkinton, MA USA.
  6. Department of Pathology; University of Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA.
  7. Department of Surgery; University Pennsylvania Perelman School of Medicine ; Philadelphia, PA USA ; Rena Rowen Breast Center; Hospital of the University of Pennsylvania ; Philadelphia, PA USA.

PMID: 26451293 PMCID: PMC4589053 DOI: 10.1080/2162402X.2015.1022301

Abstract

Genomic profiling has identified several molecular oncodrivers in breast tumorigenesis. A thorough understanding of endogenous immune responses to these oncodrivers may provide insights into immune interventions for breast cancer (BC). We investigated systemic anti-HER2/

Keywords: CD4+ T-helper immunity; HER2/neu; breast cancer; dendritic cell; immune monitoring; immune restoration; vaccination

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