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Hoeffel G, Ginhoux F. Ontogeny of Tissue-Resident Macrophages. Front Immunol. 2015;6:486doi: 10.3389/fimmu.2015.00486.
Hoeffel, G., & Ginhoux, F. (2015). Ontogeny of Tissue-Resident Macrophages. Frontiers in immunology, 6486. https://doi.org/10.3389/fimmu.2015.00486
Hoeffel, Guillaume, and Ginhoux, Florent. "Ontogeny of Tissue-Resident Macrophages." Frontiers in immunology vol. 6 (2015): 486. doi: https://doi.org/10.3389/fimmu.2015.00486
Hoeffel G, Ginhoux F. Ontogeny of Tissue-Resident Macrophages. Front Immunol. 2015 Sep 22;6:486. doi: 10.3389/fimmu.2015.00486. eCollection 2015. PMID: 26441990; PMCID: PMC4585135.
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Front Immunol. 2015 Sep 22;6:486. doi: 10.3389/fimmu.2015.00486. eCollection 2015.

Ontogeny of Tissue-Resident Macrophages.

Frontiers in immunology

Guillaume Hoeffel, Florent Ginhoux

Affiliations

  1. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (ASTAR) , Singapore , Singapore.

PMID: 26441990 PMCID: PMC4585135 DOI: 10.3389/fimmu.2015.00486

Abstract

The origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. Originally described as part of the mononuclear phagocyte system, macrophages were long thought to derive solely from adult blood circulating monocytes. However, accumulating evidence now shows that certain macrophage populations are in fact independent from monocyte and even from adult bone marrow hematopoiesis. These tissue-resident macrophages derive from sequential seeding of tissues by two precursors during embryonic development. Primitive macrophages generated in the yolk sac (YS) from early erythro-myeloid progenitors (EMPs), independently of the transcription factor c-Myb and bypassing monocytic intermediates, first give rise to microglia. Later, fetal monocytes, generated from c-Myb(+) EMPs that initially seed the fetal liver (FL), then give rise to the majority of other adult macrophages. Thus, hematopoietic stem cell-independent embryonic precursors transiently present in the YS and the FL give rise to long-lasting self-renewing macrophage populations.

Keywords: C-Myb; erythro-myeloid progenitors; fetal liver; hematopoiesis; hematopoietic stem cells; macrophages; monocytes; yolk sac

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