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Maggi J, Schafer C, Ubilla-Olguín G, et al. Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity. Front Immunol. 2015;6:488doi: 10.3389/fimmu.2015.00488.
Maggi, J., Schafer, C., Ubilla-Olguín, G., Catalán, D., Schinnerling, K., & Aguillón, J. C. (2015). Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity. Frontiers in immunology, 6488. https://doi.org/10.3389/fimmu.2015.00488
Maggi, Jaxaira, et al. "Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity." Frontiers in immunology vol. 6 (2015): 488. doi: https://doi.org/10.3389/fimmu.2015.00488
Maggi J, Schafer C, Ubilla-Olguín G, Catalán D, Schinnerling K, Aguillón JC. Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity. Front Immunol. 2015 Sep 22;6:488. doi: 10.3389/fimmu.2015.00488. eCollection 2015. PMID: 26441992; PMCID: PMC4585084.
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Front Immunol. 2015 Sep 22;6:488. doi: 10.3389/fimmu.2015.00488. eCollection 2015.

Therapeutic Potential of Hyporesponsive CD4(+) T Cells in Autoimmunity.

Frontiers in immunology

Jaxaira Maggi, Carolina Schafer, Gabriela Ubilla-Olguín, Diego Catalán, Katina Schinnerling, Juan C Aguillón

Affiliations

  1. Programa Disciplinario de Inmunología, Immune Regulation and Tolerance Research Group, Facultad de Medicina, Instituto de Ciencias Biomédicas, Universidad de Chile , Santiago , Chile ; Millennium Institute on Immunology and Immunotherapy , Santiago , Chile.

PMID: 26441992 PMCID: PMC4585084 DOI: 10.3389/fimmu.2015.00488

Abstract

The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance induction. In an immature or semi-mature state, DCs induce tolerance through T-cell deletion, generation of regulatory T cells, and/or induction of T-cell anergy. Anergy is defined as an unresponsive state that retains T cells in an "off" mode under conditions in which immune activation is undesirable. This mechanism is crucial for the control of T-cell responses against self-antigens, thereby preventing autoimmunity. Tolerogenic DCs (tDCs), generated in vitro from peripheral blood monocytes of healthy donors or patients with autoimmune pathologies, were shown to modulate immune responses by inducing T-cell hyporesponsiveness. Animal models of autoimmune diseases confirmed the impact of T-cell anergy on disease development and progression in vivo. Thus, the induction of T-cell hyporesponsiveness by tDCs has become a promising immunotherapeutic strategy for the treatment of T-cell-mediated autoimmune disorders. Here, we review recent findings in the area and discuss the potential of anergy induction for clinical purposes.

Keywords: T-cell anergy; autoimmune diseases; hyporesponsiveness; immunotherapy; regulatory T cells; tolerogenic dendritic cells

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