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Roach DR, Donovan DM. Antimicrobial bacteriophage-derived proteins and therapeutic applications. Bacteriophage. 2015;5(3):e1062590doi: 10.1080/21597081.2015.1062590.
Roach, D. R., & Donovan, D. M. (2015). Antimicrobial bacteriophage-derived proteins and therapeutic applications. Bacteriophage, 5(3), e1062590. https://doi.org/10.1080/21597081.2015.1062590
Roach, Dwayne R, and Donovan, David M. "Antimicrobial bacteriophage-derived proteins and therapeutic applications." Bacteriophage vol. 5,3 (2015): e1062590. doi: https://doi.org/10.1080/21597081.2015.1062590
Roach DR, Donovan DM. Antimicrobial bacteriophage-derived proteins and therapeutic applications. Bacteriophage. 2015 Jun 23;5(3):e1062590. doi: 10.1080/21597081.2015.1062590. eCollection 2015. PMID: 26442196; PMCID: PMC4590002.
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Bacteriophage. 2015 Jun 23;5(3):e1062590. doi: 10.1080/21597081.2015.1062590. eCollection 2015.

Antimicrobial bacteriophage-derived proteins and therapeutic applications.

Bacteriophage

Dwayne R Roach, David M Donovan

Affiliations

  1. Molecular Biology of the Genes in Extremophiles; Department of Microbiology; Institute Pasteur ; Paris, France.
  2. Animal Biosciences and Biotechnology Laboratory; NEA; Agricultural Research Service; US Department of Agriculture ; Beltsville, MD USA.

PMID: 26442196 PMCID: PMC4590002 DOI: 10.1080/21597081.2015.1062590

Abstract

Antibiotics have the remarkable power to control bacterial infections. Unfortunately, widespread use, whether regarded as prudent or not, has favored the emergence and persistence of antibiotic resistant strains of human pathogenic bacteria, resulting in a global health threat. Bacteriophages (phages) are parasites that invade the cells of virtually all known bacteria. Phages reproduce by utilizing the host cell's machinery to replicate viral proteins and genomic material, generally damaging and killing the cell in the process. Thus, phage can be exploited therapeutically as bacteriolytic agents against bacteria. Furthermore, understanding of the molecular processes involved in the viral life cycle, particularly the entry and cell lysis steps, has led to the development of viral proteins as antibacterial agents. Here we review the current preclinical state of using phage-derived endolysins, virion-associated peptidoglycan hydrolases, polysaccharide depolymerases, and holins for the treatment of bacterial infection. The scope of this review is a focus on the viral proteins that have been assessed for protective effects against human pathogenic bacteria in animal models of infection and disease.

Keywords: antibiotic resistance; antimicrobial; bacteriophage; endolysin; holin; peptidoglycan hydrolase; polysaccharide depolymerase

References

  1. Bioeng Bugs. 2011 Mar-Apr;2(2):96-9 - PubMed
  2. Future Microbiol. 2012 Oct;7(10):1147-71 - PubMed
  3. Nat Biotechnol. 2014 Nov;32(11):1146-50 - PubMed
  4. Bioeng Bugs. 2010 Jan-Feb;1(1):9-16 - PubMed
  5. MBio. 2014 Jul 01;5(4):e01379-14 - PubMed
  6. BMC Infect Dis. 2014 Aug 23;14:456 - PubMed
  7. Appl Environ Microbiol. 2009 Feb;75(3):872-4 - PubMed
  8. Appl Environ Microbiol. 2005 Aug;71(8):4872-4 - PubMed
  9. Antimicrob Agents Chemother. 2013 Dec;57(12):6276-83 - PubMed
  10. Int J Food Microbiol. 2001 Feb 28;64(1-2):71-80 - PubMed
  11. Biochem Soc Trans. 2012 Dec 1;40(6):1503-6 - PubMed
  12. Curr Microbiol. 2011 Dec;63(6):538-42 - PubMed
  13. Nature. 2002 Aug 22;418(6900):884-9 - PubMed
  14. Antimicrob Agents Chemother. 2015 Apr;59(4):1983-91 - PubMed
  15. Microbiology. 1998 Nov;144 ( Pt 11):3039-47 - PubMed
  16. Antimicrob Agents Chemother. 2014 Jul;58(7):3774-84 - PubMed
  17. FEMS Microbiol Lett. 2000 Dec 1;193(1):57-62 - PubMed
  18. Antimicrob Agents Chemother. 2013 Jun;57(6):2743-50 - PubMed
  19. PLoS One. 2012;7(5):e36991 - PubMed
  20. Appl Environ Microbiol. 2013 May;79(10):3249-56 - PubMed
  21. Adv Virus Res. 2012;83:3-40 - PubMed
  22. Antimicrob Agents Chemother. 2012 Oct;56(10):5031-9 - PubMed
  23. Appl Environ Microbiol. 2012 Apr;78(7):2297-305 - PubMed
  24. J Antimicrob Chemother. 2015;70(6):1763-73 - PubMed
  25. Antimicrob Agents Chemother. 2005 Jul;49(7):2934-40 - PubMed
  26. Crit Care Med. 2009 Feb;37(2):642-9 - PubMed
  27. Appl Environ Microbiol. 2007 Jan;73(1):347-52 - PubMed
  28. Crit Rev Microbiol. 2013 Nov;39(4):427-34 - PubMed
  29. Science. 2001 Dec 7;294(5549):2170-2 - PubMed
  30. BMC Microbiol. 2011 Oct 11;11:226 - PubMed
  31. Bioeng Bugs. 2010 Nov-Dec;1(6):404-7 - PubMed
  32. J Biol Chem. 2005 Oct 21;280(42):35433-9 - PubMed
  33. FEMS Microbiol Lett. 2013 May;342(1):30-6 - PubMed
  34. J Med Microbiol. 2013 Oct;62(Pt 10):1506-16 - PubMed
  35. BMC Microbiol. 2011 Jun 17;11:138 - PubMed
  36. Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10765-70 - PubMed
  37. Appl Microbiol Biotechnol. 2007 Apr;74(6):1284-91 - PubMed
  38. J Antimicrob Chemother. 2015 May;70(5):1453-65 - PubMed
  39. Antimicrob Agents Chemother. 2014;58(4):2084-8 - PubMed
  40. Front Microbiol. 2014 Oct 20;5:551 - PubMed
  41. Curr Microbiol. 2009 Jun;58(6):609-15 - PubMed
  42. Microbiology. 2010 Jul;156(Pt 7):2205-15 - PubMed
  43. Antimicrob Agents Chemother. 2007 Feb;51(2):475-82 - PubMed
  44. Appl Environ Microbiol. 2007 Nov;73(22):7150-4 - PubMed
  45. Curr Pharm Biotechnol. 2010 Jan;11(1):69-86 - PubMed
  46. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):5497-502 - PubMed
  47. J Exp Med. 1931 Jun 30;54(1):51-71 - PubMed
  48. Microb Biotechnol. 2011 Sep;4(5):651-62 - PubMed
  49. Med Hypotheses. 2010 Jan;74(1):164-6 - PubMed
  50. Gene. 2009 Aug 15;443(1-2):32-41 - PubMed
  51. Curr Microbiol. 2012 Jul;65(1):28-34 - PubMed
  52. Antimicrob Agents Chemother. 2014 Aug;58(8):4621-9 - PubMed
  53. Infect Immun. 2003 Nov;71(11):6199-204 - PubMed
  54. J Bacteriol. 2006 Apr;188(7):2711-4 - PubMed
  55. Antimicrob Agents Chemother. 2014 Jun;58(6):3073-84 - PubMed
  56. Antimicrob Agents Chemother. 2005 Mar;49(3):1225-8 - PubMed
  57. FEBS Lett. 2001 Jun 29;500(1-2):56-9 - PubMed
  58. Antimicrob Agents Chemother. 2003 Jan;47(1):375-7 - PubMed
  59. Bacteriophage. 2014 Mar 06;4:e28451 - PubMed
  60. J Antimicrob Chemother. 2005 Jul;56(1):160-5 - PubMed
  61. J Exp Med. 1932 Sep 30;56(4):521-30 - PubMed
  62. Plasmid. 2015 May;79:1-7 - PubMed
  63. J Exp Med. 1932 Feb 29;55(3):393-404 - PubMed
  64. BMC Microbiol. 2012 Mar 22;12:41 - PubMed
  65. FEMS Microbiol Lett. 2006 Dec;265(1):133-9 - PubMed
  66. J Bacteriol. 2004 Jul;186(14):4808-12 - PubMed
  67. Front Public Health. 2014 Sep 16;2:145 - PubMed
  68. J Bacteriol. 2011 Oct;193(19):5477-86 - PubMed
  69. J Microbiol. 2014 Mar;52(3):243-58 - PubMed
  70. Antimicrob Agents Chemother. 2011 Feb;55(2):738-44 - PubMed
  71. Annu Rev Immunol. 2014;32:433-59 - PubMed
  72. Antimicrob Agents Chemother. 2011 Apr;55(4):1764-7 - PubMed
  73. J Bacteriol. 1999 Aug;181(15):4452-60 - PubMed
  74. J Biol Chem. 1999 May 28;274(22):15847-56 - PubMed
  75. Adv Exp Med Biol. 2014;807:97-110 - PubMed
  76. J Appl Microbiol. 2011 Mar;110(3):778-85 - PubMed
  77. Appl Environ Microbiol. 2012 Apr;78(7):2241-8 - PubMed
  78. J Bacteriol. 1966 Jul;92(1):56-62 - PubMed
  79. J Infect Dis. 2007 Oct 15;196(8):1237-47 - PubMed
  80. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4107-12 - PubMed
  81. J Clin Microbiol. 2011 Jan;49(1):111-7 - PubMed
  82. Bacteriol Rev. 1972 Dec;36(4):407-77 - PubMed
  83. J Exp Med. 1934 Apr 30;59(5):641-67 - PubMed
  84. Antimicrob Agents Chemother. 2005 Jan;49(1):111-7 - PubMed
  85. FEMS Microbiol Lett. 2009 May;294(1):52-60 - PubMed
  86. J Mol Biol. 2007 Feb 16;366(2):540-50 - PubMed
  87. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12752-7 - PubMed
  88. J Bacteriol. 2012 Dec;194(23):6498-506 - PubMed
  89. Appl Microbiol Biotechnol. 2011 Apr;90(2):529-39 - PubMed
  90. J Microbiol Biotechnol. 2014 Jun 28;24(6):803-11 - PubMed
  91. Biotechnol Biofuels. 2013 Feb 07;6(1):20 - PubMed
  92. Appl Environ Microbiol. 2007 Mar;73(6):1992-2000 - PubMed
  93. J Basic Microbiol. 2007 Apr;47(2):103-17 - PubMed
  94. J Biosci Bioeng. 2001;91(5):469-73 - PubMed
  95. Microbiology. 2004 Jul;150(Pt 7):2079-87 - PubMed
  96. Virology. 2011 Mar 15;411(2):393-415 - PubMed
  97. Plant Cell Rep. 2005 Feb;23(9):632-8 - PubMed
  98. Adv Virus Res. 2012;83:123-41 - PubMed
  99. FEMS Microbiol Lett. 2006 Jun;259(1):41-6 - PubMed
  100. Vet Microbiol. 2008 Jul 27;130(1-2):107-17 - PubMed
  101. Int J Antimicrob Agents. 2011 May;37(5):432-7 - PubMed
  102. Future Microbiol. 2013 Jun;8(6):769-83 - PubMed
  103. J Infect Dis. 2008 Jun 1;197(11):1519-22 - PubMed
  104. Int J Mol Sci. 2012 Oct 30;13(11):14002-15 - PubMed
  105. J Mol Microbiol Biotechnol. 2002 Jan;4(1):21-36 - PubMed
  106. Appl Microbiol Biotechnol. 2013 May;97(10):4369-75 - PubMed
  107. J Antimicrob Chemother. 2013 Sep;68(9):2111-7 - PubMed
  108. J Appl Microbiol. 2010 Feb;108(2):695-702 - PubMed
  109. Nat Rev Microbiol. 2014 Jul;12(7):465-78 - PubMed
  110. Int J Antimicrob Agents. 2013 Feb;41(2):156-61 - PubMed
  111. FEMS Microbiol Lett. 2011 Aug;321(1):58-66 - PubMed
  112. Antimicrob Agents Chemother. 2005 Nov;49(11):4789-92 - PubMed
  113. J Biol Chem. 2012 Jul 6;287(28):23381-96 - PubMed
  114. Appl Environ Microbiol. 2006 Oct;72(10):6825-8 - PubMed
  115. Curr Opin Microbiol. 2013 Dec;16(6):790-7 - PubMed
  116. Front Microbiol. 2014 Oct 16;5:542 - PubMed
  117. Proc Natl Acad Sci U S A. 2013 May 28;110(22):E2054-63 - PubMed
  118. PLoS Pathog. 2007 Mar;3(3):e28 - PubMed
  119. FEMS Microbiol Lett. 2008 Oct;287(1):22-33 - PubMed
  120. Adv Appl Microbiol. 2010;70:217-48 - PubMed
  121. PLoS One. 2013 Jun 21;8(6):e67950 - PubMed
  122. PLoS One. 2010 Nov 22;5(11):e13904 - PubMed
  123. Appl Microbiol Biotechnol. 2011 Feb;89(4):1061-73 - PubMed
  124. Mol Microbiol. 2011 Sep;81(6):1419-32 - PubMed
  125. J Virol. 2013 Apr;87(8):4558-70 - PubMed
  126. Mol Microbiol. 2002 Apr;44(2):335-49 - PubMed
  127. Trends Microbiol. 2005 Oct;13(10):491-6 - PubMed
  128. Appl Environ Microbiol. 2006 Jul;72(7):5108-12 - PubMed
  129. Appl Microbiol Biotechnol. 2004 Jul;65(1):105-9 - PubMed
  130. Antimicrob Agents Chemother. 2013 Nov;57(11):5355-65 - PubMed
  131. J Bacteriol. 2005 Oct;187(20):7161-4 - PubMed
  132. Antimicrob Agents Chemother. 2010 Apr;54(4):1603-12 - PubMed
  133. J Virol. 1969 Mar;3(3):290-6 - PubMed
  134. BioDrugs. 2014 Jun;28(3):265-74 - PubMed
  135. J Bacteriol. 2015 Jan 1;197(1):7-17 - PubMed
  136. Microbiology. 2004 Aug;150(Pt 8):2707-14 - PubMed
  137. J Exp Med. 1959 Dec 1;110:853-74 - PubMed
  138. J Antimicrob Chemother. 2003 Dec;52(6):967-73 - PubMed
  139. Biopolymers. 2008;90(5):604-10 - PubMed

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