Display options
Cite
Hayashi A, Nomura H, Mochizuki R, et al. Writing Impairments in Japanese Patients with Mild Cognitive Impairment and with Mild Alzheimer's Disease. Dement Geriatr Cogn Dis Extra. 2015;5(3):309-19doi: 10.1159/000437297.
Hayashi, A., Nomura, H., Mochizuki, R., Ohnuma, A., Kimpara, T., Suzuki, K., & Mori, E. (2015). Writing Impairments in Japanese Patients with Mild Cognitive Impairment and with Mild Alzheimer's Disease. Dementia and geriatric cognitive disorders extra, 5(3), 309-19. https://doi.org/10.1159/000437297
Hayashi, Atsuko, et al. "Writing Impairments in Japanese Patients with Mild Cognitive Impairment and with Mild Alzheimer's Disease." Dementia and geriatric cognitive disorders extra vol. 5,3 (2015): 309-19. doi: https://doi.org/10.1159/000437297
Hayashi A, Nomura H, Mochizuki R, Ohnuma A, Kimpara T, Suzuki K, Mori E. Writing Impairments in Japanese Patients with Mild Cognitive Impairment and with Mild Alzheimer's Disease. Dement Geriatr Cogn Dis Extra. 2015 Sep 04;5(3):309-19. doi: 10.1159/000437297. eCollection 2015. PMID: 26483830; PMCID: PMC4608664.
Copy Download .nbib Format: NLM
Share it on

Dement Geriatr Cogn Dis Extra. 2015 Sep 04;5(3):309-19. doi: 10.1159/000437297. eCollection 2015.

Writing Impairments in Japanese Patients with Mild Cognitive Impairment and with Mild Alzheimer's Disease.

Dementia and geriatric cognitive disorders extra

Atsuko Hayashi, Hiroshi Nomura, Ruriko Mochizuki, Ayumu Ohnuma, Teiko Kimpara, Kyoko Suzuki, Etsuro Mori

Affiliations

  1. Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan.
  2. Department of Neurology, Kohnan Hospital, Tohoku University Graduate School of Medicine, Sendai, Japan.
  3. Department of Clinical Neuroscience, Yamagata University Graduate School of Medicine, Yamagata, Japan.
  4. Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine, Sendai, Japan.

PMID: 26483830 PMCID: PMC4608664 DOI: 10.1159/000437297

Abstract

BACKGROUND/AIMS: We investigated writing abilities in patients with the amnestic type of mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD). To examine the earliest changes in writing function, we used writing tests for both words and sentences with different types of Japanese characters (Hiragana, Katakana, and Kanji).

METHODS: A total of 25 aMCI patients, 38 AD patients, and 22 healthy controls performed writing to dictation for Kana and Kanji words, copied Kanji words, and wrote in response to a picture story task. Analysis of variance was used to test the subject group effects on the scores in the above writing tasks.

RESULTS: For the written Kanji words, the mild AD group performed worse than the aMCI group and the controls, but there was no difference between the aMCI group and the controls. For the picture story writing task, the mild AD and aMCI groups performed worse than the controls, but the difference between the AD and the aMCI groups was not significant.

CONCLUSIONS: The mild AD group showed defects in writing Kanji characters, and the aMCI group showed impairments in narrative writing. Our study suggests that narrative writing, which demands complex integration of multiple cognitive functions, can be used to detect the subtle writing deficits in aMCI patients.

Keywords: Dementia; Kana; Kanji; Mild cognitive impairment; Narrative writing; Writing disorder

References

  1. Brain. 1989 Dec;112 ( Pt 6):1549-61 - PubMed
  2. Cortex. 2006 Jul;42(5):675-84 - PubMed
  3. Neuropsychologia. 2011 Jun;49(7):1962-8 - PubMed
  4. Psychopharmacol Bull. 1983;19(3):448-50 - PubMed
  5. Neuropsychologia. 1997 Apr;35(4):533-45 - PubMed
  6. J Clin Exp Neuropsychol. 1989 Oct;11(5):692-8 - PubMed
  7. Lancet Neurol. 2004 Apr;3(4):246-8 - PubMed
  8. Neurology. 1993 Nov;43(11):2412-4 - PubMed
  9. Arch Neurol. 1999 Mar;56(3):303-8 - PubMed
  10. Arch Neurol. 1992 Nov;49(11):1151-6 - PubMed
  11. Arch Neurol. 1989 Jan;46(1):65-8 - PubMed
  12. Dement Geriatr Cogn Disord. 1999 May-Jun;10(3):226-30 - PubMed
  13. No To Shinkei. 2002 Jun;54(6):481-8 - PubMed
  14. J Neurol Sci. 2006 Dec 1;250(1-2):3-9 - PubMed
  15. Neurology. 1992 Apr;42(4):777-84 - PubMed
  16. Arch Neurol. 1988 Jul;45(7):760-3 - PubMed
  17. Brain Res Bull. 2004 Mar 1;63(1):19-24 - PubMed
  18. Arch Gerontol Geriatr. 1990 Sep-Oct;11(2):155-9 - PubMed
  19. J Neurol. 2010 Dec;257(12):2071-7 - PubMed
  20. Arch Neurol. 1993 Jan;50(1):81-6 - PubMed
  21. Dement Geriatr Cogn Disord. 2006;21(5-6):284-90 - PubMed
  22. Neurology. 1984 Jul;34(7):939-44 - PubMed
  23. Brain Lang. 1996 Apr;53(1):1-19 - PubMed

Publication Types