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Ozarowski M, Thiem B, Mikolajczak PL, et al. Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study. Evid Based Complement Alternat Med. 2015;2015:145140doi: 10.1155/2015/145140.
Ozarowski, M., Thiem, B., Mikolajczak, P. L., Piasecka, A., Kachlicki, P., Szulc, M., Kaminska, E., Bogacz, A., Kujawski, R., Bartkowiak-Wieczorek, J., Kujawska, M., Jodynis-Liebert, J., Budzianowski, J., Kędziora, I., Seremak-Mrozikiewicz, A., Czerny, B., & Bobkiewicz-Kozłowska, T. (2015). Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study. Evidence-based complementary and alternative medicine : eCAM, 2015145140. https://doi.org/10.1155/2015/145140
Ozarowski, Marcin, et al. "Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 145140. doi: https://doi.org/10.1155/2015/145140
Ozarowski M, Thiem B, Mikolajczak PL, Piasecka A, Kachlicki P, Szulc M, Kaminska E, Bogacz A, Kujawski R, Bartkowiak-Wieczorek J, Kujawska M, Jodynis-Liebert J, Budzianowski J, Kędziora I, Seremak-Mrozikiewicz A, Czerny B, Bobkiewicz-Kozłowska T. Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study. Evid Based Complement Alternat Med. 2015;2015:145140. doi: 10.1155/2015/145140. Epub 2015 Sep 21. PMID: 26483842; PMCID: PMC4592897.
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Evid Based Complement Alternat Med. 2015;2015:145140. doi: 10.1155/2015/145140. Epub 2015 Sep 21.

Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study.

Evidence-based complementary and alternative medicine : eCAM

Marcin Ozarowski, Barbara Thiem, Przemyslaw L Mikolajczak, Anna Piasecka, Piotr Kachlicki, Michal Szulc, Ewa Kaminska, Anna Bogacz, Radoslaw Kujawski, Joanna Bartkowiak-Wieczorek, Malgorzata Kujawska, Jadwiga Jodynis-Liebert, Jaromir Budzianowski, Izabela Kędziora, Agnieszka Seremak-Mrozikiewicz, Boguslaw Czerny, Teresa Bobkiewicz-Kozłowska

Affiliations

  1. Department of Pharmaceutical Botany and Plant Biotechnology, Poznan University of Medical Sciences, Sw. Marii Magdaleny 14, 61-861 Poznan, Poland ; Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland.
  2. Department of Pharmaceutical Botany and Plant Biotechnology, Poznan University of Medical Sciences, Sw. Marii Magdaleny 14, 61-861 Poznan, Poland.
  3. Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Department of Pharmacology, University of Medical Sciences, Rokietnicka 5a, 60-806 Poznan, Poland.
  4. Department of Pathogen Genetics and Plant Resistance, Metabolomics Team, Institute of Plant Genetics of the Polish Academy of Science, Strzeszynska 34, 60-479 Poznan, Poland.
  5. Department of Pharmacology, University of Medical Sciences, Rokietnicka 5a, 60-806 Poznan, Poland.
  6. Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, University of Medical Sciences, Sw. Marii Magdaleny 14, 61-861 Poznan, Poland.
  7. Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland.
  8. Department of Toxicology, Poznan University of Medical Sciences, Dojazd 30, 60-631 Poznan, Poland.
  9. Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Division of Perinatology and Women's Diseases, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland ; Laboratory of Molecular Biology, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.
  10. Department of Pharmacology and Phytochemistry, Institute of Natural Fibers and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland ; Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University, Zolnierska 48, 70-204 Szczecin, Poland ; Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, Libelta 27, 61-707 Poznan, Poland.

PMID: 26483842 PMCID: PMC4592897 DOI: 10.1155/2015/145140

Abstract

Eryngium planum L. (EP) is as a rare medicinal plant with a lot of potentials as pharmaceutical crops. The aim of our study was to assess the effect of subchronic (28-fold) administration of a 70% ethanol extract of EP roots (200 mg/kg, p.o.) on behavioral and cognitive responses in Wistar rats linked with acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and beta-secretase (BACE-1) mRNA levels and AChE and BuChE activities in the hippocampus and frontal cortex. On the last day of experiment, 30 min after the last dose of EP or Huperzine A (HU), scopolamine (SC) was given at a dose of 0.5 mg/kg b.w. intraperitoneally. The results of a passive avoidance test showed an improvement in long-term memory produced by the EP extract in both scopolamine-induced rats and control group. EP caused an insignificant inhibition of AChE and BuChE activities in the frontal cortex and the hippocampus. EP decreased mRNA AChE, BuChE, and BACE-1 levels, especially in the cortex. Our results suggest that the EP extract led to the improvement of the long-term memory in rats coupled with total saponin content. The mechanism of EP action is probably complicated, since HPLC-MS analysis showed 64 chemical compounds (phenolics, saponins) in the extract of EP roots.

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