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Goulart LI, Pedrazolli M, Martori AH, et al. Narcolepsy with cataplexy in monozygotic twins. Sleep Sci. 2014;7(1):62-4doi: 10.1016/j.slsci.2014.01.001.
Goulart, L. I., Pedrazolli, M., Martori, A. H., Eckeli, A., & Sander, H. H. (2014). Narcolepsy with cataplexy in monozygotic twins. Sleep science (Sao Paulo, Brazil), 7(1), 62-4. https://doi.org/10.1016/j.slsci.2014.01.001
Goulart, Leonardo I, et al. "Narcolepsy with cataplexy in monozygotic twins." Sleep science (Sao Paulo, Brazil) vol. 7,1 (2014): 62-4. doi: https://doi.org/10.1016/j.slsci.2014.01.001
Goulart LI, Pedrazolli M, Martori AH, Eckeli A, Sander HH. Narcolepsy with cataplexy in monozygotic twins. Sleep Sci. 2014 Mar;7(1):62-4. doi: 10.1016/j.slsci.2014.01.001. Epub 2014 Sep 10. PMID: 26483904; PMCID: PMC4521643.
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Sleep Sci. 2014 Mar;7(1):62-4. doi: 10.1016/j.slsci.2014.01.001. Epub 2014 Sep 10.

Narcolepsy with cataplexy in monozygotic twins.

Sleep science (Sao Paulo, Brazil)

Leonardo I Goulart, Mário Pedrazolli, Alexandre H Martori, Alan Eckeli, Heidi H Sander

Affiliations

  1. Clinical Neurophysiology Department, Hospital Israelita Albert Einstein, São Paulo, Brazil.
  2. Discipline of Gerontology, Universidade de São Paulo, Brazil.
  3. Neurology Deptartment, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brazil.

PMID: 26483904 PMCID: PMC4521643 DOI: 10.1016/j.slsci.2014.01.001

Abstract

INTRODUCTION: This paper describes narcolepsy with cataplexy in two monozygotic twin sisters.

OBJECTIVE: To clinically illustrate the involvement of neurological, genetic and immunologic systems in narcolepsy.

MATERIAL AND METHODS: We performed a restropective study of these patients that were followed in the sleep medicine ambulatory clinic of the Faculdade de Medicina de Ribeirao Preto.

RESULTS: These sisters are two of the few cases in the literature concordant for narcolepsy with catalepsy and without a "positive HLA" for narcolepsy. They had a typical clinical course of narcolepsy with cataplexy and attended all the neurophysiological diagnostic criteria for narcolepsy.

CONCLUSION: In addition to known possible genetical similarity, this report stresses the role of environmental or unknown genetical factors acting on a specific neuro-imuno-genetical background and resulting in narcolepsy.

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