Display options
Cite
Garcia-Rill E, Luster B, Mahaffey S, et al. Pedunculopontine arousal system physiology - Implications for insomnia. Sleep Sci. 2015;8(2):92-9doi: 10.1016/j.slsci.2015.06.002.
Garcia-Rill, E., Luster, B., Mahaffey, S., Bisagno, V., & Urbano, F. J. (2015). Pedunculopontine arousal system physiology - Implications for insomnia. Sleep science (Sao Paulo, Brazil), 8(2), 92-9. https://doi.org/10.1016/j.slsci.2015.06.002
Garcia-Rill, Edgar, et al. "Pedunculopontine arousal system physiology - Implications for insomnia." Sleep science (Sao Paulo, Brazil) vol. 8,2 (2015): 92-9. doi: https://doi.org/10.1016/j.slsci.2015.06.002
Garcia-Rill E, Luster B, Mahaffey S, Bisagno V, Urbano FJ. Pedunculopontine arousal system physiology - Implications for insomnia. Sleep Sci. 2015 Apr-Jun;8(2):92-9. doi: 10.1016/j.slsci.2015.06.002. Epub 2015 Jul 10. PMID: 26483950; PMCID: PMC4608886.
Copy Download .nbib Format: NLM
Share it on

Sleep Sci. 2015 Apr-Jun;8(2):92-9. doi: 10.1016/j.slsci.2015.06.002. Epub 2015 Jul 10.

Pedunculopontine arousal system physiology - Implications for insomnia.

Sleep science (Sao Paulo, Brazil)

Edgar Garcia-Rill, Brennon Luster, Susan Mahaffey, Veronica Bisagno, Francisco J Urbano

Affiliations

  1. Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
  2. IFIBYNE-CONICET and ININFA-CONICET, University of Buenos Aires, Argentina.

PMID: 26483950 PMCID: PMC4608886 DOI: 10.1016/j.slsci.2015.06.002

Abstract

We consider insomnia a disorder of waking rather than a disorder of sleep. This review examines the role of the reticular activating system, especially the pedunculopontine nucleus, in the symptoms of insomnia, mainly representing an overactive waking drive. We determined that high frequency activity during waking and REM sleep is controlled by two different intracellular pathways and channel types in PPN cells. We found three different PPN cell types that have one or both channels and may be active during waking only, REM sleep only, or both. These discoveries point to a specific mechanism and novel therapeutic avenues for insomnia.

Keywords: CaMKII, calcium/calmodulin-dependent protein kinase; Calcium channels; EEG, electroencephalogram; Gamma band activity; KA, kainic acid; N-type calcium channel; NCS-1, neuronal calcium sensor protein 1; NMDA, n methyl d aspartic acid; Neuronal calcium sensor protein; P/Q-type calcium channel; PGO, ponto-geniculo-occipital; PPN, pedunculopontine nucleus; RAS, reticular activating system; REM, rapid eye movement; SWS, slow wave sleep; cAMP, cyclic adenosine monophosphate; ω-Aga, ω-agatoxin-IVA; ω-CgTx, ω-conotoxin-GVIA

References

  1. J Physiol. 2005 Oct 1;568(Pt 1):199-209 - PubMed
  2. Neuron. 2010 Nov 4;68(3):362-85 - PubMed
  3. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15245-50 - PubMed
  4. J Neurophysiol. 1992 Oct;68(4):1359-72 - PubMed
  5. Physiol Rep. 2015 Jun;3(6):null - PubMed
  6. Proc Natl Acad Sci U S A. 2007 Nov 6;104(45):17819-24 - PubMed
  7. J Neurosci Res. 2001 Oct 1;66(1):109-16 - PubMed
  8. J Neurosci Res. 2002 Nov 15;70(4):611-21 - PubMed
  9. Sleep Med Rev. 2010 Feb;14(1):19-31 - PubMed
  10. Sleep. 2001 Feb 1;24(1):110-7 - PubMed
  11. Neuroscience. 2009 Sep 29;163(1):397-414 - PubMed
  12. J Neurophysiol. 2015 Feb 1;113(3):709-19 - PubMed
  13. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4396-400 - PubMed
  14. Eur J Neurosci. 2009 Jan;29(2):340-58 - PubMed
  15. Neuroscience. 1997 Jun;78(3):771-94 - PubMed
  16. J Gen Physiol. 2003 Jun;121(6):495-510 - PubMed
  17. Sleep Med Rev. 2010 Feb;14(1):9-15 - PubMed
  18. Trends Neurosci. 2003 Dec;26(12):683-7 - PubMed
  19. J Neurosci. 2011 Nov 23;31(47):17007-16 - PubMed
  20. Sleep. 2007 Nov;30(11):1405-14 - PubMed
  21. J Neurochem. 2011 Feb;116(4):577-87 - PubMed
  22. Curr Opin Neurobiol. 2005 Jun;15(3):257-65 - PubMed
  23. J Psychosom Res. 2005 Mar;58(3):271-8 - PubMed
  24. Exp Brain Res. 2014 May;232(5):1509-22 - PubMed
  25. J Neurophysiol. 2002 Apr;87(4):1790-8 - PubMed
  26. Am J Physiol Regul Integr Comp Physiol. 2001 Mar;280(3):R752-9 - PubMed
  27. Eur J Neurosci. 2011 Aug;34(3):404-15 - PubMed
  28. Neuron. 1995 Oct;15(4):929-40 - PubMed
  29. Biol Psychol. 2012 Dec;91(3):329-33 - PubMed
  30. Sleep Med Rev. 2014 Jun;18(3):195-213 - PubMed
  31. Clin Neurophysiol. 2014 May;125(5):979-87 - PubMed
  32. J Neurosci. 1990 Aug;10(8):2560-79 - PubMed
  33. Int J Psychophysiol. 2013 Aug;89(2):171-80 - PubMed
  34. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):341-6 - PubMed
  35. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):313-7 - PubMed
  36. Arch Gen Psychiatry. 2002 Feb;59(2):131-6 - PubMed
  37. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):724-8 - PubMed
  38. Brain Res. 1990 Sep 17;527(2):213-23 - PubMed
  39. Sleep Med Rev. 2013 Jun;17(3):227-38 - PubMed
  40. J Neurophysiol. 2010 Jul;104(1):463-74 - PubMed
  41. J Neurosci. 2010 Sep 15;30(37):12263-73 - PubMed
  42. J Neurophysiol. 1997 Jun;77(6):2975-88 - PubMed
  43. J Appl Physiol (1985). 2013 Nov 1;115(9):1402-14 - PubMed
  44. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3567-72 - PubMed
  45. J Neurosci. 1990 Aug;10(8):2541-59 - PubMed

Publication Types

Grant support