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Yoo TH, Fornoni A. Nonimmunologic targets of immunosuppressive agents in podocytes. Kidney Res Clin Pract. 2015;34(2):69-75doi: 10.1016/j.krcp.2015.03.003.
Yoo, T. H., & Fornoni, A. (2015). Nonimmunologic targets of immunosuppressive agents in podocytes. Kidney research and clinical practice, 34(2), 69-75. https://doi.org/10.1016/j.krcp.2015.03.003
Yoo, Tae-Hyun, and Fornoni, Alessia. "Nonimmunologic targets of immunosuppressive agents in podocytes." Kidney research and clinical practice vol. 34,2 (2015): 69-75. doi: https://doi.org/10.1016/j.krcp.2015.03.003
Yoo TH, Fornoni A. Nonimmunologic targets of immunosuppressive agents in podocytes. Kidney Res Clin Pract. 2015 Jun;34(2):69-75. doi: 10.1016/j.krcp.2015.03.003. Epub 2015 Apr 09. PMID: 26484025; PMCID: PMC4570600.
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Kidney Res Clin Pract. 2015 Jun;34(2):69-75. doi: 10.1016/j.krcp.2015.03.003. Epub 2015 Apr 09.

Nonimmunologic targets of immunosuppressive agents in podocytes.

Kidney research and clinical practice

Tae-Hyun Yoo, Alessia Fornoni

Affiliations

  1. Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea ; Division of Nephrology and Hypertension, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA ; Peggy and Harold Katz Family Drug Discovery Center, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
  2. Division of Nephrology and Hypertension, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA ; Peggy and Harold Katz Family Drug Discovery Center, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.

PMID: 26484025 PMCID: PMC4570600 DOI: 10.1016/j.krcp.2015.03.003

Abstract

Proteinuria is a characteristic finding in glomerular diseases and is closely associated with renal outcomes. In addition, therapeutic interventions that reduce proteinuria improve renal prognosis. Accumulating evidence has demonstrated that podocytes act as key modulators of glomerular injury and proteinuria. The podocyte, or glomerular visceral epithelial cell, is a highly specialized and differentiated cell that forms interdigitated foot processes with neighboring podocytes, which are bridged together by an extracellular structure known as the "slit diaphragm" (SD). The SD acts as a size- and charge-selective barrier to plasma protein. Derangement of SD structure or loss of SD-associated protein results in podocyte injury and proteinuria. During the past decades, several immune-modulating agents have been used for the treatment of glomerular diseases and for the reduction of proteinuria. Interestingly, recent studies have demonstrated that immunosuppressive agents can have a direct effect on the SD-associated proteins and stabilize actin cytoskeleton in podocyte and have therefore introduced the concept of nonimmunologic mechanism of renoprotection by immunomodulators. This review focuses on the evidence that immuno-modulating agents directly target podocytes.

Keywords: Immunomodulation; Nephrotic syndrome; Podocyte; Proteinuria

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