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Lai MK, Esiri MM, Tan MG. Genome-wide profiling of alternative splicing in Alzheimer's disease. Genom Data. 2014;2:290-2doi: 10.1016/j.gdata.2014.09.002.
Lai, M. K., Esiri, M. M., & Tan, M. G. (2014). Genome-wide profiling of alternative splicing in Alzheimer's disease. Genomics data, 2290-2. https://doi.org/10.1016/j.gdata.2014.09.002
Lai, Mitchell K P, et al. "Genome-wide profiling of alternative splicing in Alzheimer's disease." Genomics data vol. 2 (2014): 290-2. doi: https://doi.org/10.1016/j.gdata.2014.09.002
Lai MK, Esiri MM, Tan MG. Genome-wide profiling of alternative splicing in Alzheimer's disease. Genom Data. 2014 Sep 07;2:290-2. doi: 10.1016/j.gdata.2014.09.002. eCollection 2014 Dec. PMID: 26484111; PMCID: PMC4535993.
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Genom Data. 2014 Sep 07;2:290-2. doi: 10.1016/j.gdata.2014.09.002. eCollection 2014 Dec.

Genome-wide profiling of alternative splicing in Alzheimer's disease.

Genomics data

Mitchell K P Lai, Margaret M Esiri, Michelle G K Tan

Affiliations

  1. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  2. Oxford Project to Investigate Memory and Ageing (OPTIMA), University of Oxford, John Radcliffe Hospital, Oxford, UK.
  3. Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore ; Department of Clinical Research, Singapore General Hospital, Singapore 169856, Singapore.

PMID: 26484111 PMCID: PMC4535993 DOI: 10.1016/j.gdata.2014.09.002

Abstract

Alternative splicing is a highly regulated process which generates transcriptome and proteome diversity through the skipping or inclusion of exons within gene loci. Identification of aberrant alternative splicing associated with human diseases has become feasible with the development of new genomic technologies and powerful bioinformatics. We have previously reported genome-wide gene alterations in the neocortex of a well-characterized cohort of Alzheimer's disease (AD) patients and matched elderly controls using a commercial exon microarray platform [1]. Here, we provide detailed description of analyses aimed at identifying differential alternative splicing events associated with AD.

Keywords: Alternative splicing; Alzheimer's disease; Exon array; Genome-wide profiling; Transcript variant

References

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  3. Acta Neuropathol. 1991;82(4):239-59 - PubMed
  4. Neurology. 1991 Apr;41(4):479-86 - PubMed
  5. Neurology. 1984 Jul;34(7):939-44 - PubMed

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