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de Vries SP, Bootsma HJ. Differential gene expression of Moraxella catarrhalis upon exposure to human serum. Genom Data. 2014;2:312-3doi: 10.1016/j.gdata.2014.09.008.
de Vries, S. P., & Bootsma, H. J. (2014). Differential gene expression of Moraxella catarrhalis upon exposure to human serum. Genomics data, 2312-3. https://doi.org/10.1016/j.gdata.2014.09.008
de Vries, Stefan P W, and Bootsma, Hester J. "Differential gene expression of Moraxella catarrhalis upon exposure to human serum." Genomics data vol. 2 (2014): 312-3. doi: https://doi.org/10.1016/j.gdata.2014.09.008
de Vries SP, Bootsma HJ. Differential gene expression of Moraxella catarrhalis upon exposure to human serum. Genom Data. 2014 Oct 02;2:312-3. doi: 10.1016/j.gdata.2014.09.008. eCollection 2014 Dec. PMID: 26484117; PMCID: PMC4536000.
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Genom Data. 2014 Oct 02;2:312-3. doi: 10.1016/j.gdata.2014.09.008. eCollection 2014 Dec.

Differential gene expression of Moraxella catarrhalis upon exposure to human serum.

Genomics data

Stefan P W de Vries, Hester J Bootsma

Affiliations

  1. Laboratory of Pediatric Infectious Diseases, Radboud University Medical Centre, Nijmegen, The Netherlands.

PMID: 26484117 PMCID: PMC4536000 DOI: 10.1016/j.gdata.2014.09.008

Abstract

The complement system is an important part of the innate defense against invading pathogens (Blom et al., 2009; [1]). The ability to resist complement-mediated killing is considered to be an important virulence trait for the human-restricted respiratory tract pathogen Moraxella catarrhalis, as most disease-associated M. catarrhalis isolates are complement-resistant (Wirth et al., 2007; [2]). Here we provide a detailed overview of the experimental methods that we have used to study the molecular basis of M. catarrhalis complement-resistance by transcriptome profiling of the bacterium upon exposure to 10% normal human serum (NHS), associated with the study of de Vries et al. published in Molecular Microbiology in 2014 [3].

Keywords: Moraxella catarrhalis; Serum resistance; Transcriptional profiling

References

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