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Lin RC, Ng SF, Morris MJ. Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. Genom Data. 2014;2:351-3doi: 10.1016/j.gdata.2014.09.013.
Lin, R. C., Ng, S. F., & Morris, M. J. (2014). Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. Genomics data, 2351-3. https://doi.org/10.1016/j.gdata.2014.09.013
Lin, Ruby C Y, et al. "Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity." Genomics data vol. 2 (2014): 351-3. doi: https://doi.org/10.1016/j.gdata.2014.09.013
Lin RC, Ng SF, Morris MJ. Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity. Genom Data. 2014 Oct 16;2:351-3. doi: 10.1016/j.gdata.2014.09.013. eCollection 2014 Dec. PMID: 26484128; PMCID: PMC4536069.
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Genom Data. 2014 Oct 16;2:351-3. doi: 10.1016/j.gdata.2014.09.013. eCollection 2014 Dec.

Gene expression in rat models for inter-generational transmission of islet dysfunction and obesity.

Genomics data

Ruby C Y Lin, Sheau-Fang Ng, Margaret J Morris

Affiliations

  1. Asbestos Diseases Research Institute, NSW, 2139 Sydney, Australia ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, NSW 2052, Australia.
  2. Department of Paediatrics, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Center, Universiti Kebangsaan Malaysia, 56000 Kuala Lumpur, Malaysia ; Department of Pharmacology, School of Medical Sciences, University New South Wales, NSW 2052, Australia.
  3. Department of Pharmacology, School of Medical Sciences, University New South Wales, NSW 2052, Australia.

PMID: 26484128 PMCID: PMC4536069 DOI: 10.1016/j.gdata.2014.09.013

Abstract

Paternal high fat diet (HFD) consumption triggers unique gene signatures, consistent with premature aging and chronic degenerative disorders, in both white adipose tissue (RpWAT) and pancreatic islets of daughters. In addition to published data in Nature, 2010, 467, 963-966 (GSE: 19877, islet) and FASEB J 2014, 28, 1830-1841 (GSE: 33551, RpWAT), we describe here additional details on systems-based approaches and analysis to develop our observations. Our data provides a resource for exploring the complex molecular mechanisms that underlie intergenerational transmission of obesity.

Keywords: Gene signatures; High fat diet; Intergenerational transmission; Islet dysfunction; Paternal transmission

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