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Aguiar-Ricardo A, Bonifácio VD, Casimiro T, et al. Supercritical carbon dioxide design strategies: from drug carriers to soft killers. Philos Trans A Math Phys Eng Sci. 2015;373(2057)doi: 10.1098/rsta.2015.0009.
Aguiar-Ricardo, A., Bonifácio, V. D., Casimiro, T., & Correia, V. G. (2015). Supercritical carbon dioxide design strategies: from drug carriers to soft killers. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 373(2057), . https://doi.org/10.1098/rsta.2015.0009
Aguiar-Ricardo, Ana, et al. "Supercritical carbon dioxide design strategies: from drug carriers to soft killers." Philosophical transactions. Series A, Mathematical, physical, and engineering sciences vol. 373,2057 (2015). doi: https://doi.org/10.1098/rsta.2015.0009
Aguiar-Ricardo A, Bonifácio VD, Casimiro T, Correia VG. Supercritical carbon dioxide design strategies: from drug carriers to soft killers. Philos Trans A Math Phys Eng Sci. 2015 Dec 28;373(2057). doi: 10.1098/rsta.2015.0009. PMID: 26574528.
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Philos Trans A Math Phys Eng Sci. 2015 Dec 28;373(2057). doi: 10.1098/rsta.2015.0009.

Supercritical carbon dioxide design strategies: from drug carriers to soft killers.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences

Ana Aguiar-Ricardo, Vasco D B Bonifácio, Teresa Casimiro, Vanessa G Correia

Affiliations

  1. LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, Caparica 2829-516, Portugal [email protected].
  2. CQFM and IN, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisboa 1049-001, Portugal.
  3. LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, Caparica 2829-516, Portugal.

PMID: 26574528 DOI: 10.1098/rsta.2015.0009

Abstract

The integrated use of supercritical carbon dioxide (scCO(2)) and micro- and nanotechnologies has enabled new sustainable strategies for the manufacturing of new medications. 'Green' scCO(2)-based methodologies are well suited to improve either the synthesis or materials processing leading to the assembly of three-dimensional multifunctional constructs. By using scCO(2) either as C1 feedstock or as solvent, simple, economic, efficient and clean routes can be designed to synthesize materials with unique properties such as polyurea dendrimers and oxazoline-based polymers/oligomers. These new biocompatible, biodegradable and water-soluble polymeric materials can be engineered into multifunctional constructs with antimicrobial activity, targeting moieties, labelling units and/or efficiently loaded with therapeutics. This mini-review highlights the particular features exhibited by these materials resulting directly from the followed supercritical routes.

© 2015 The Author(s).

Keywords: POxylation; antimicrobial activity; dendrimers; drug delivery; oligo-oxazolines; supercritical carbon dioxide

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