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Fonseca P, Dias A, Gonçalves H, et al. Acute hepatitis after amiodarone infusion. World J Clin Cases. 2015;3(10):900-3doi: 10.12998/wjcc.v3.i10.900.
Fonseca, P., Dias, A., Gonçalves, H., Albuquerque, A., & Gama, V. (2015). Acute hepatitis after amiodarone infusion. World journal of clinical cases, 3(10), 900-3. https://doi.org/10.12998/wjcc.v3.i10.900
Fonseca, Paulo, et al. "Acute hepatitis after amiodarone infusion." World journal of clinical cases vol. 3,10 (2015): 900-3. doi: https://doi.org/10.12998/wjcc.v3.i10.900
Fonseca P, Dias A, Gonçalves H, Albuquerque A, Gama V. Acute hepatitis after amiodarone infusion. World J Clin Cases. 2015 Oct 16;3(10):900-3. doi: 10.12998/wjcc.v3.i10.900. PMID: 26488027; PMCID: PMC4607809.
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World J Clin Cases. 2015 Oct 16;3(10):900-3. doi: 10.12998/wjcc.v3.i10.900.

Acute hepatitis after amiodarone infusion.

World journal of clinical cases

Paulo Fonseca, Adelaide Dias, Helena Gonçalves, Aníbal Albuquerque, Vasco Gama

Affiliations

  1. Paulo Fonseca, Adelaide Dias, Helena Gonçalves, Aníbal Albuquerque, Vasco Gama, Cardiology Department, Gaia Hospital Center, 4434-502 Vila Nova de Gaia, Portugal.

PMID: 26488027 PMCID: PMC4607809 DOI: 10.12998/wjcc.v3.i10.900

Abstract

Acute hepatitis is a very rare, but potentially fatal, adverse effect of intravenous amiodarone. We present a case of an 88-year-old man with history of ischemic dilated cardiomyopathy and severely depressed left ventricular function that was admitted to our coronary care unit with diagnosis of decompensated heart failure and non-sustained ventricular tachycardia. A few hours after the beginning of intravenous amiodarone he developed an acute hepatitis. There was a completely recovery within the next days after amiodarone withdrawn and other causes of acute hepatitis have been ruled out. This case highlights the need for close monitoring of hepatic function during amiodarone infusion in order to identify any potential hepatotoxicity and prevent a fatal outcome. Oral amiodarone is, apparently, a safe option in these patients.

Keywords: Amiodarone; Hepatitis; Hepatotoxicity; Idiosyncratic reactions; Polysorbate 80

References

  1. J Pharmacol Exp Ther. 2004 Dec;311(3):864-73 - PubMed
  2. Hepatology. 1989 May;9(5):679-85 - PubMed
  3. Pediatrics. 1986 Sep;78(3):503-6 - PubMed
  4. Gut. 1993 Apr;34(4):565-6 - PubMed
  5. J Cardiovasc Pharmacol Ther. 1997 Jan;2(1):53-60 - PubMed
  6. Hepatogastroenterology. 1991 Feb;38(1):71-4 - PubMed
  7. Am J Emerg Med. 2007 Nov;25(9):1082.e1-4 - PubMed
  8. Int J Clin Pharmacol Ther. 2008 Feb;46(2):96-101 - PubMed
  9. Clin Cardiol. 1986 May;9(5):223-5 - PubMed
  10. Hepatology. 2005 Apr;41(4):925-35 - PubMed
  11. Am J Gastroenterol. 2014 Jul;109 (7):950-66; quiz 967 - PubMed
  12. Int J Clin Pharmacol Ther. 1998 Jun;36(6):350-2 - PubMed
  13. Am J Ther. 2016 Jan-Feb;23 (1):e260-3 - PubMed
  14. Int J Cardiol. 2003 Oct;91(2-3):245-7 - PubMed
  15. J Clin Epidemiol. 1993 Nov;46(11):1323-30 - PubMed

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