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Noordzij W, Slart RH. PET imaging of the autonomic myocardial function: methods and interpretation. Clin Transl Imaging. 2015;3(5):365-372doi: 10.1007/s40336-015-0139-6.
Noordzij, W., & Slart, R. H. (2015). PET imaging of the autonomic myocardial function: methods and interpretation. Clinical and translational imaging, 3(5), 365-372. https://doi.org/10.1007/s40336-015-0139-6
Noordzij, Walter, and Slart, Riemer H J A. "PET imaging of the autonomic myocardial function: methods and interpretation." Clinical and translational imaging vol. 3,5 (2015): 365-372. doi: https://doi.org/10.1007/s40336-015-0139-6
Noordzij W, Slart RH. PET imaging of the autonomic myocardial function: methods and interpretation. Clin Transl Imaging. 2015;3(5):365-372. doi: 10.1007/s40336-015-0139-6. Epub 2015 Sep 10. PMID: 26457273; PMCID: PMC4592500.
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Clin Transl Imaging. 2015;3(5):365-372. doi: 10.1007/s40336-015-0139-6. Epub 2015 Sep 10.

PET imaging of the autonomic myocardial function: methods and interpretation.

Clinical and translational imaging

Walter Noordzij, Riemer H J A Slart

Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Hanzeplein 1, P.O. Box 30001, 9700 RB Groningen, The Netherlands.

PMID: 26457273 PMCID: PMC4592500 DOI: 10.1007/s40336-015-0139-6

Abstract

Cardiac positron emission tomography (PET) is mainly applied in myocardial perfusion and viability detection. Noninvasive imaging of myocardial innervation using PET is a valuable additional methodology in cardiac imaging. Novel methods and different PET ligands have been developed to measure presynaptic and postsynaptic function of the cardiac neuronal system. Obtained PET data can be analysed quantitatively or interpreted qualitatively. Thus far, PET is not a widely used clinical application in autonomic heart imaging; however, due to its technical advantages, the excellent properties of the imaging agents, and the availability of tools for quantification, it deserves a better position in the clinic. From a historical point of view, the focus of PET software packages for image analysis was mainly oncology and neurology driven. Actually, commercially available software for cardiac PET image analysis is still only available for the quantification of myocardial blood flow. Thus far, no commercial software package is available for the interpretation and quantification of PET innervation scans. However, image data quantification and analysis of kinetic data can be performed using adjusted generic tools. This paper gives an overview of different neuronal PET ligands, interpretation and quantification of acquired PET data.

Keywords: Interpretation; Methods; Myocardial innervation; PET

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