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Gowda C, McKittrick N, Kim D, et al. Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons. AIDS Res Treat. 2015;2015:653840doi: 10.1155/2015/653840.
Gowda, C., McKittrick, N., Kim, D., Kappes, R. A., Lo Re, V., & Tebas, P. (2015). Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons. AIDS research and treatment, 2015653840. https://doi.org/10.1155/2015/653840
Gowda, Charitha, et al. "Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons." AIDS research and treatment vol. 2015 (2015): 653840. doi: https://doi.org/10.1155/2015/653840
Gowda C, McKittrick N, Kim D, Kappes RA, Lo Re V, Tebas P. Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons. AIDS Res Treat. 2015;2015:653840. doi: 10.1155/2015/653840. Epub 2015 Oct 12. PMID: 26576297; PMCID: PMC4630342.
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AIDS Res Treat. 2015;2015:653840. doi: 10.1155/2015/653840. Epub 2015 Oct 12.

Obesity Is Not Associated with Impaired Immune Response to Influenza Vaccination in HIV-Infected Persons.

AIDS research and treatment

Charitha Gowda, Noah McKittrick, Deborah Kim, Rosemarie A Kappes, Vincent Lo Re, Pablo Tebas

Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  2. Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA 94305, USA.
  3. Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

PMID: 26576297 PMCID: PMC4630342 DOI: 10.1155/2015/653840

Abstract

Introduction. HIV-infected individuals demonstrate lower immunogenicity to the influenza vaccine, despite immunologic and virologic control of HIV infection. Obesity has been previously shown to be associated with diminished antibody responses to other vaccines in HIV-uninfected persons. However, no studies have examined if obesity is associated with diminished protective immune response to influenza vaccination among HIV-infected persons on antiretroviral therapy (ART). Methods. We performed a retrospective analysis of immunogenicity data from a clinical trial of inactivated, trivalent influenza vaccine. The primary endpoint was the proportion of participants with seroconversion, defined as >4-fold increase in anti-hemagglutinin antibody titers after vaccination. Secondary endpoints were the proportion of participants with seroprotection (defined as antibody titers of ≥1 : 40) and geometric mean hemagglutination inhibition antibody titers. Results. Overall, 48 (27%) participants were obese (body mass index ≥ 30 kg/m(2)). Seroconversion rates were comparable between obese and nonobese subjects for all three vaccine strains. Further, postvaccination geometric mean titers did not differ by body mass index category. Conclusion. Obesity was not associated with diminished antibody response to influenza vaccination in a sample of healthy HIV-infected persons.

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