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Aleshkin AV, Rubalskii EO, Volozhantsev NV, et al. A small-scale experiment of using phage-based probiotic dietary supplement for prevention of E. coli traveler's diarrhea. Bacteriophage. 2015;5(3):e1074329doi: 10.1080/21597081.2015.1074329.
Aleshkin, A. V., Rubalskii, E. O., Volozhantsev, N. V., Verevkin, V. V., Svetoch, E. A., Kiseleva, I. A., Bochkareva, S. S., Borisova, O. Y., Popova, A. V., Bogun, A. G., & Afanas'ev, S. S. (2015). A small-scale experiment of using phage-based probiotic dietary supplement for prevention of E. coli traveler's diarrhea. Bacteriophage, 5(3), e1074329. https://doi.org/10.1080/21597081.2015.1074329
Aleshkin, A V, et al. "A small-scale experiment of using phage-based probiotic dietary supplement for prevention of E. coli traveler's diarrhea." Bacteriophage vol. 5,3 (2015): e1074329. doi: https://doi.org/10.1080/21597081.2015.1074329
Aleshkin AV, Rubalskii EO, Volozhantsev NV, Verevkin VV, Svetoch EA, Kiseleva IA, Bochkareva SS, Borisova OY, Popova AV, Bogun AG, Afanas'ev SS. A small-scale experiment of using phage-based probiotic dietary supplement for prevention of E. coli traveler's diarrhea. Bacteriophage. 2015 Jul 24;5(3):e1074329. doi: 10.1080/21597081.2015.1074329. eCollection 2015. PMID: 26458758; PMCID: PMC4589986.
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Bacteriophage. 2015 Jul 24;5(3):e1074329. doi: 10.1080/21597081.2015.1074329. eCollection 2015.

A small-scale experiment of using phage-based probiotic dietary supplement for prevention of E. coli traveler's diarrhea.

Bacteriophage

A V Aleshkin, E O Rubalskii, N V Volozhantsev, V V Verevkin, E A Svetoch, I A Kiseleva, S S Bochkareva, O Yu Borisova, A V Popova, A G Bogun, S S Afanas'ev

Affiliations

  1. Bphage LLC ; Moscow, Russia ; Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology ; Moscow, Russia.
  2. State Research Center for Applied Microbiology & Biotechnology ; Obolensk , Moscow region, Russia.
  3. Gabrichevsky Moscow Research Institute for Epidemiology and Microbiology ; Moscow, Russia.
  4. Bphage LLC ; Moscow, Russia ; State Research Center for Applied Microbiology & Biotechnology ; Obolensk , Moscow region, Russia.

PMID: 26458758 PMCID: PMC4589986 DOI: 10.1080/21597081.2015.1074329

Abstract

Traveler's diarrhea (TD) is caused by Escherichia coli in 30% of cases. We have developed a phage cocktail for prophylaxis of TD caused by E.coli, Shigella flexneri, Shigella sonnei, Salmonella enterica, Listeria monocytogenes or Staphylococcus aureus, and investigated its effectiveness against infection caused by the non-pathogenic Lac (-) strain of E.coli K12 C600 in animal and human trials. On the 6th day of both animal and human trials E. coli K12 C600 strain was detected in titer of 10

Keywords: EAEC; EHEC; ETEC; phage prophylaxis; phage-based probiotic dietary supplement; traveler's diarrhea

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