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Krause BJ, Herrera EA, Díaz-López FA, et al. Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses. J Dev Orig Health Dis. 2015;7(3):237-243doi: 10.1017/S2040174415007266.
Krause, B. J., Herrera, E. A., Díaz-López, F. A., Farías, M., Uauy, R., & Casanello, P. (2016). Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses. Journal of developmental origins of health and disease, 7(3), 237-243. https://doi.org/10.1017/S2040174415007266
Krause, B J, et al. "Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses." Journal of developmental origins of health and disease vol. 7,3 (2016): 237-243. doi: https://doi.org/10.1017/S2040174415007266
Krause BJ, Herrera EA, Díaz-López FA, Farías M, Uauy R, Casanello P. Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses. J Dev Orig Health Dis. 2016 Jun;7(3):237-243. doi: 10.1017/S2040174415007266. Epub 2015 Oct 22. PMID: 26490762.
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J Dev Orig Health Dis. 2016 Jun;7(3):237-243. doi: 10.1017/S2040174415007266. Epub 2015 Oct 22.

Pre-gestational overweight in guinea pig sows induces fetal vascular dysfunction and increased rate of large and small fetuses.

Journal of developmental origins of health and disease

B J Krause, E A Herrera, F A Díaz-López, M Farías, R Uauy, P Casanello

Affiliations

  1. 1Division of Obstetrics & Gynaecology,School of Medicine,Pontificia Universidad Católica de Chile,Santiago,Chile.
  2. 3Programa de Fisiopatología,Instituto de Ciencias Biomédicas, Facultad de Medicina,Universidad de Chile,Santiago,Chile.
  3. 2Division of Paediatrics, Faculty of Medicine,Pontificia Universidad Católica de Chile,Santiago,Chile.

PMID: 26490762 DOI: 10.1017/S2040174415007266

Abstract

In humans, obesity before and during pregnancy is associated with both fetal macrosomia and growth restriction, and long-term cardiovascular risk in the offspring. We aimed to determine whether overweighted pregnant guinea pig sows results in an increased fetal weight at term and the effects on the vascular reactivity in fetal systemic and umbilical arteries. Pregnant guinea pigs were classified as control (n=4) or high weight (HWS, n=5) according to their pre-mating weight, and their fetuses extracted at 0.9 gestation (~60 days). Segments of fetal femoral and umbilical arteries were mounted in a wire myograph, where the contractile response to KCl (5-125 mM), and the relaxation to nitric oxide synthase-dependent agents (insulin, 10-10-10-7 and acetylcholine, 10-10-10-5) and nitric oxide [sodium nitroprusside (SNP), 10-10-10-5] were determined. Fetuses from HWS (HWSF) were grouped according to their body weight as low (85 g) fetal weight, based on the confidence interval (76.5-84.9 g) of the control group. No HWSF were observed in the normal range. Umbilical arteries from HWSF showed a lower response to KCl and insulin compared with controls, but a comparable response with SNP. Conversely, femoral arteries from HWSF showed an increased response to KCl and acetylcholine, along with a decreased sensitivity to SNP. These data show that overweight sows have altered fetal growth along gestation. Further, large and small fetuses from obese guinea pig sows showed altered vascular reactivity at umbilical and systemic vessels, which potentially associates with long-term cardiovascular risk.

Keywords: cardiovascular; fetus; maternal pregnancy; obesity

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