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Catalán-García M, Garrabou G, Morén C, et al. BACE-1, PS-1 and sAPPβ Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies. Mol Med. 2015;21(1):817-823doi: 10.2119/molmed.2015.00168.
Catalán-García, M., Garrabou, G., Morén, C., Guitart-Mampel, M., Gonzalez-Casacuberta, I., Hernando, A., Gallego-Escuredo, J. M., Yubero, D., Villarroya, F., Montero, R., O-Callaghan, A. S., Cardellach, F., & Grau, J. M. (2016). BACE-1, PS-1 and sAPPβ Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies. Molecular medicine (Cambridge, Mass.), 21(1), 817-823. https://doi.org/10.2119/molmed.2015.00168
Catalán-García, Marc, et al. "BACE-1, PS-1 and sAPPβ Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies." Molecular medicine (Cambridge, Mass.) vol. 21,1 (2016): 817-823. doi: https://doi.org/10.2119/molmed.2015.00168
Catalán-García M, Garrabou G, Morén C, Guitart-Mampel M, Gonzalez-Casacuberta I, Hernando A, Gallego-Escuredo JM, Yubero D, Villarroya F, Montero R, O-Callaghan AS, Cardellach F, Grau JM. BACE-1, PS-1 and sAPPβ Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies. Mol Med. 2016 Mar;21(1):817-823. doi: 10.2119/molmed.2015.00168. Epub 2015 Nov 03. PMID: 26552061; PMCID: PMC4818257.
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Mol Med. 2016 Mar;21(1):817-823. doi: 10.2119/molmed.2015.00168. Epub 2015 Nov 03.

BACE-1, PS-1 and sAPPβ Levels Are Increased in Plasma from Sporadic Inclusion Body Myositis Patients: Surrogate Biomarkers among Inflammatory Myopathies.

Molecular medicine (Cambridge, Mass.)

Marc Catalán-García, Glòria Garrabou, Constanza Morén, Mariona Guitart-Mampel, Ingrid Gonzalez-Casacuberta, Adriana Hernando, Jose Miquel Gallego-Escuredo, Dèlia Yubero, Francesc Villarroya, Raquel Montero, Albert Selva O-Callaghan, Francesc Cardellach, Josep Maria Grau

Affiliations

  1. Laboratory of Muscle Research and Mitochondrial Function, Cellex-IDIBAPS, Faculty of Medicine, University of Barcelona, Department of Internal Medicine, Hospital Clinic of Barcelona, Barcelona, Spain.
  2. Department of Biochemistry and Molecular Biology, Institute of Biomedicine (University of Barcelona), University of Barcelona, and CIBEROBN, Barcelona, Spain.
  3. Clinical Biochemistry Department, Hospital Sant Joan de Déu, Barcelona, Spain, and CIBERER, Valencia, Spain.
  4. Internal Medicine Department, Hospital Vall d'Hebron, Barcelona, Spain.

PMID: 26552061 PMCID: PMC4818257 DOI: 10.2119/molmed.2015.00168

Abstract

Sporadic inclusion body myositis (sIBM) is a rare disease that is difficult to diagnose. Muscle biopsy provides three prominent pathological findings: inflammation, mitochondrial abnormalities and fibber degeneration, represented by the accumulation of protein depots constituted by β-amyloid peptide, among others. We aim to perform a screening in plasma of circulating molecules related to the putative etiopathogenesis of sIBM to determine potential surrogate biomarkers for diagnosis. Plasma from 21 sIBM patients and 20 age- and gender-paired healthy controls were collected and stored at -80°C. An additional population of patients with non-sIBM inflammatory myopathies was also included (nine patients with dermatomyositis and five with polymyositis). Circulating levels of inflammatory cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α), mitochondrial-related molecules (free plasmatic mitochondrial DNA [mtDNA], fibroblast growth factor-21 [FGF-21] and coenzyme-Q10 [CoQ]) and amyloidogenic-related molecules (beta-secretase-1 [BACE-1], presenilin-1 [PS-1], and soluble Aβ precursor protein [sAPPβ]) were assessed with magnetic bead-based assays, real-time polymerase chain reaction, enzyme-linked immunosorbent assay (ELISA) and high-pressure liquid chromatography (HPLC). Despite remarkable trends toward altered plasmatic expression of inflammatory and mitochondrial molecules (increased IL-6, TNF-α, circulating mtDNA and FGF-21 levels and decreased content in CoQ), only amyloidogenic degenerative markers including BACE-1, PS-1 and sAPPβ levels were significantly increased in plasma from sIBM patients compared with controls and other patients with non-sIBM inflammatory myopathies (

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