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Sagnelli C, Martini S, Pisaturo M, et al. Liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfection: Diagnostic methods and clinical impact. World J Hepatol. 2015;7(24):2510-21doi: 10.4254/wjh.v7.i24.2510.
Sagnelli, C., Martini, S., Pisaturo, M., Pasquale, G., Macera, M., Zampino, R., Coppola, N., & Sagnelli, E. (2015). Liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfection: Diagnostic methods and clinical impact. World journal of hepatology, 7(24), 2510-21. https://doi.org/10.4254/wjh.v7.i24.2510
Sagnelli, Caterina, et al. "Liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfection: Diagnostic methods and clinical impact." World journal of hepatology vol. 7,24 (2015): 2510-21. doi: https://doi.org/10.4254/wjh.v7.i24.2510
Sagnelli C, Martini S, Pisaturo M, Pasquale G, Macera M, Zampino R, Coppola N, Sagnelli E. Liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfection: Diagnostic methods and clinical impact. World J Hepatol. 2015 Oct 28;7(24):2510-21. doi: 10.4254/wjh.v7.i24.2510. PMID: 26523204; PMCID: PMC4621465.
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World J Hepatol. 2015 Oct 28;7(24):2510-21. doi: 10.4254/wjh.v7.i24.2510.

Liver fibrosis in human immunodeficiency virus/hepatitis C virus coinfection: Diagnostic methods and clinical impact.

World journal of hepatology

Caterina Sagnelli, Salvatore Martini, Mariantonietta Pisaturo, Giuseppe Pasquale, Margherita Macera, Rosa Zampino, Nicola Coppola, Evangelista Sagnelli

Affiliations

  1. Caterina Sagnelli, Department of Clinical and Experimental Medicine and Surgery "F. Magrassi e A. Lanzara, Second University of Naples, 80131 Naples, Italy.

PMID: 26523204 PMCID: PMC4621465 DOI: 10.4254/wjh.v7.i24.2510

Abstract

Several non-invasive surrogate methods have recently challenged the main role of liver biopsy in assessing liver fibrosis in hepatitis C virus (HCV)-monoinfected and human immunodeficiency virus (HIV)/HCV-coinfected patients, applied to avoid the well-known side effects of liver puncture. Serological tests involve the determination of biochemical markers of synthesis or degradation of fibrosis, tests not readily available in clinical practice, or combinations of routine tests used in chronic hepatitis and HIV/HCV coinfection. Several radiologic techniques have also been proposed, some of which commonly used in clinical practice. The studies performed to compare the prognostic value of non-invasive surrogate methods with that of the degree of liver fibrosis assessed on liver tissue have not as yet provided conclusive results. Each surrogate technique has shown some limitations, including the risk of over- or under-estimating the extent of liver fibrosis. The current knowledge on liver fibrosis in HIV/HCV-coinfected patients will be summarized in this review article, which is addressed in particular to physicians involved in this setting in their clinical practice.

Keywords: Fibroscan; Human immunodeficiency virus/hepatitis C virus coinfection; Liver biopsy; Liver fibrosis; Liver ultrasonography

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