Display options
Cite
Micks E, Raglan GB, Schulkin J. Bridging progestogens in pregnancy and pregnancy prevention. Endocr Connect. 2015;4(4):R81-92doi: 10.1530/EC-15-0093.
Micks, E., Raglan, G. B., & Schulkin, J. (2015). Bridging progestogens in pregnancy and pregnancy prevention. Endocrine connections, 4(4), R81-92. https://doi.org/10.1530/EC-15-0093
Micks, Elizabeth, et al. "Bridging progestogens in pregnancy and pregnancy prevention." Endocrine connections vol. 4,4 (2015): R81-92. doi: https://doi.org/10.1530/EC-15-0093
Micks E, Raglan GB, Schulkin J. Bridging progestogens in pregnancy and pregnancy prevention. Endocr Connect. 2015 Dec;4(4):R81-92. doi: 10.1530/EC-15-0093. PMID: 26581227; PMCID: PMC4653318.
Copy Download .nbib Format: NLM
Share it on

Endocr Connect. 2015 Dec;4(4):R81-92. doi: 10.1530/EC-15-0093.

Bridging progestogens in pregnancy and pregnancy prevention.

Endocrine connections

Elizabeth Micks, Greta B Raglan, Jay Schulkin

Affiliations

  1. Department of Obstetrics and GynecologyUniversity of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USADepartment of ResearchAmerican College of Obstetricians and Gynecologists, 409 12th Street SW, Washington, District of Columbia, USA [email protected].
  2. Department of Obstetrics and GynecologyUniversity of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USADepartment of ResearchAmerican College of Obstetricians and Gynecologists, 409 12th Street SW, Washington, District of Columbia, USA.
  3. Department of Obstetrics and GynecologyUniversity of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USADepartment of ResearchAmerican College of Obstetricians and Gynecologists, 409 12th Street SW, Washington, District of Columbia, USA Department of Obstetrics and GynecologyUniversity of Washington, Box 356460, 1959 NE Pacific Street, Seattle, Washington, USADepartment of ResearchAmerican College of Obstetricians and Gynecologists, 409 12th Street SW, Washington, District of Columbia, USA.

PMID: 26581227 PMCID: PMC4653318 DOI: 10.1530/EC-15-0093

Abstract

Steroid hormones have been in use for more than a half a century as contraceptive agents, and only now are researchers elucidating the biochemical mechanisms of action and non-target effects. Progesterone and synthetic progestins, critical for women's health in the US and internationally, appear to have important effects on immune functioning and other diverse systems. Apart from the contraceptive world is a separate field that is devoted to understanding progesterone in other contexts. Based on research following a development timeline parallel to hormonal contraception, progesterone and 17-hydroxyprogesterone caproate are now administered to prevent preterm birth in high-risk pregnant women. Preterm birth researchers are similarly working to determine the precise biochemical actions and immunological effects of progesterone. Progesterone research in both areas could benefit from increased collaboration and bringing these two bodies of literature together. Progesterone, through actions on various hormone receptors, has lifelong importance in different organ systems and researchers have much to learn about this molecule from the combination of existing literatures, and from future studies that build on this combined knowledge base.

© 2015 The authors.

Keywords: collaborative research; contraception; pregnancy; preterm birth; progestogens

References

  1. Obstet Gynecol. 2015 Jul;126(1):12-21 - PubMed
  2. Obstet Gynecol. 2009 Dec;114(6):1434-8 - PubMed
  3. J Steroid Biochem Mol Biol. 2013 Sep;137:57-70 - PubMed
  4. Am J Obstet Gynecol. 2003 Feb;188(2):419-24 - PubMed
  5. MMWR Recomm Rep. 2010 Jun 18;59(RR-4):1-86 - PubMed
  6. Contraception. 2010 Oct;82(4):314-23 - PubMed
  7. Contraception. 2013 Apr;87(4):426-31 - PubMed
  8. Am J Perinatol. 2008 Sep;25(8):503-6 - PubMed
  9. Biol Reprod. 2003 Jul;69(1):331-7 - PubMed
  10. Biochem Soc Trans. 2012 Feb;40(1):200-4 - PubMed
  11. Cell Mol Life Sci. 2009 Aug;66(15):2405-26 - PubMed
  12. J Clin Endocrinol Metab. 2005 Sep;90(9):5279-86 - PubMed
  13. J Clin Oncol. 2009 Nov 1;27(31):5138-43 - PubMed
  14. Am J Obstet Gynecol. 1960 Jan;79:172-6 - PubMed
  15. Perspect Sex Reprod Health. 2012 Mar;44(1):57-64 - PubMed
  16. Psychoneuroendocrinology. 1991;16(1-3):213-78 - PubMed
  17. Am J Obstet Gynecol. 2013 Jun;208(6):421-6 - PubMed
  18. Lancet. 2010 Feb 13;375(9714):555-62 - PubMed
  19. Biol Reprod. 1999 May;60(5):1158-65 - PubMed
  20. J Biol Chem. 2004 Oct 29;279(44):46315-25 - PubMed
  21. Health Care Women Int. 2016;37(2):197-215 - PubMed
  22. Int J Gynaecol Obstet. 2013 May;121 Suppl 1:S9-15 - PubMed
  23. Reprod Biol. 2013 Dec;13(4):279-89 - PubMed
  24. J Clin Endocrinol Metab. 2012 May;97(5):E719-30 - PubMed
  25. Ann N Y Acad Sci. 1958 Jul 30;71(5):762-86 - PubMed
  26. Endocrinology. 2011 Aug;152(8):3172-81 - PubMed
  27. Mol Hum Reprod. 2001 Jun;7(6):581-6 - PubMed
  28. J Natl Cancer Inst. 1999 Jul 7;91(13):1131-7 - PubMed
  29. J Asthma. 2013 Apr;50(3):223-30 - PubMed
  30. Curr Opin Obstet Gynecol. 2014 Aug;26(4):237-42 - PubMed
  31. Endocr Rev. 1997 Aug;18(4):502-19 - PubMed
  32. Contraception. 2009 Aug;80(2):113-8 - PubMed
  33. Ann Pharmacother. 2013 Apr;47(4):527-36 - PubMed
  34. Contraception. 2013 Feb;87(2):126-7 - PubMed
  35. Steroids. 2000 Oct-Nov;65(10-11):693-7 - PubMed
  36. Semin Reprod Med. 2015 Jan;33(1):23-9 - PubMed
  37. Contraception. 2011 Oct;84(4):423-35 - PubMed
  38. Fertil Steril. 2014 Jun;101(6):1656-62.e1-4 - PubMed
  39. PLoS One. 2013 May 03;8(5):e62895 - PubMed
  40. N Engl J Med. 2007 Aug 2;357(5):462-9 - PubMed
  41. Am J Public Health. 2014 Feb;104 Suppl 1:S43-8 - PubMed
  42. Lancet Infect Dis. 2013 Sep;13(9):797-808 - PubMed
  43. Steroids. 2003 Nov;68(10-13):761-70 - PubMed
  44. Am J Obstet Gynecol. 2010 Sep;203(3):248.e1-9 - PubMed
  45. N Engl J Med. 2007 Aug 2;357(5):454-61 - PubMed
  46. Semin Reprod Med. 2007 May;25(3):208-19 - PubMed
  47. J Midwifery Womens Health. 2007 Jul-Aug;52(4):361-7 - PubMed
  48. Gen Comp Endocrinol. 1990 Nov;80(2):299-313 - PubMed
  49. Lancet Glob Health. 2014 Jun;2(6):e323-33 - PubMed
  50. Reprod Sci. 2011 Jan;18(1):6-19 - PubMed
  51. Clin Dev Immunol. 2012;2012:937618 - PubMed
  52. Hum Reprod. 2010 Feb;25(2):345-53 - PubMed
  53. Obstet Gynecol. 2007 Oct;110(4):865-72 - PubMed
  54. Mol Cell Endocrinol. 1997 Dec 12;135(2):101-7 - PubMed
  55. Fam Plann Perspect. 1998 Jan-Feb;30(1):24-9, 46 - PubMed
  56. Am J Obstet Gynecol. 2012 Nov;207(5):396.e1-8 - PubMed
  57. Am J Obstet Gynecol. 2013 Jan;208(1):42.e1-42.e18 - PubMed
  58. J Pharm Pract. 2012 Jun;25(3):331-40 - PubMed
  59. Ultrasound Obstet Gynecol. 2007 Oct;30(5):687-96 - PubMed
  60. Ultrasound Obstet Gynecol. 2011 Sep;38(3):272-80 - PubMed
  61. Am J Obstet Gynecol. 1951 Mar;61(3):653-6 - PubMed
  62. J Matern Fetal Neonatal Med. 2006 Dec;19(12):763-72 - PubMed
  63. Semin Fetal Neonatal Med. 2006 Oct;11(5):317-26 - PubMed
  64. Front Biosci. 2007 Jan 01;12:912-8 - PubMed
  65. Int J Gynaecol Obstet. 2010 May;109(2):128-30 - PubMed
  66. Lancet Infect Dis. 2012 Jan;12(1):19-26 - PubMed
  67. Gynecol Endocrinol. 2014 Oct;30(10):688-90 - PubMed
  68. Ultrasound Obstet Gynecol. 2011 Jul;38(1):18-31 - PubMed
  69. Contraception. 2013 Sep;88(3):418-25 - PubMed
  70. Int J Fertil Steril. 2013 Jul;7(2):74-81 - PubMed
  71. Arch Pediatr Adolesc Med. 2005 Oct;159(10):957-62 - PubMed
  72. J Clin Endocrinol Metab. 1999 Nov;84(11):4055-61 - PubMed
  73. Fertil Steril. 2012 Oct;98(4):1053-9 - PubMed
  74. Cochrane Database Syst Rev. 2015 Mar 10;(3):CD002229 - PubMed
  75. Int J Gynaecol Obstet. 2009 Jan;104(1):40-3 - PubMed
  76. Am J Obstet Gynecol. 1954 Feb;67(2):339-41 - PubMed
  77. Behav Processes. 2012 Jun;90(2):210-6 - PubMed
  78. Q Rev Biol. 2013 Jun;88(2):97-116 - PubMed
  79. Contraception. 2011 Oct;84(4):363-7 - PubMed
  80. Front Neurosci. 2013 Sep 19;7:159 - PubMed
  81. Science. 2003 Sep 19;301(5640):1714-7 - PubMed
  82. Lancet. 2009 Jun 13;373(9680):2034-40 - PubMed
  83. Infect Immun. 2013 Apr;81(4):1234-44 - PubMed
  84. Dev Biol. 2000 Jun 15;222(2):326-35 - PubMed
  85. Gynecol Endocrinol. 2009 Oct;25(10 ):668-73 - PubMed
  86. Br Med J. 1963 Feb 2;1(5326):292-5 - PubMed
  87. Brain Res. 2013 Sep 12;1530:82-105 - PubMed
  88. Am J Obstet Gynecol. 2012 Feb;206(2):129.e1-8 - PubMed
  89. Acta Obstet Gynecol Scand. 2009;88(11):1180-9 - PubMed
  90. J Endocrinol. 1982 Oct;95(1):147-51 - PubMed
  91. J Pediatr Adolesc Gynecol. 2012 Feb;25(1):23-6 - PubMed
  92. Contraception. 2011 May;83(5):397-404 - PubMed
  93. J Urol. 1999 Jun;161(6):1954-7 - PubMed
  94. N Engl J Med. 2003 Jun 12;348(24):2379-85 - PubMed
  95. Am J Obstet Gynecol. 1999 Nov;181(5 Pt 1):1263-9 - PubMed

Publication Types