Display options
Cite
Fu T, Znalesniak EB, Kalinski T, et al. TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii. Eur J Microbiol Immunol (Bp). 2015;5(3):221-31doi: 10.1556/1886.2015.00028.
Fu, T., Znalesniak, E. B., Kalinski, T., Möhle, L., Biswas, A., Salm, F., Dunay, I. R., & Hoffmann, W. (2015). TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii. European journal of microbiology & immunology, 5(3), 221-31. https://doi.org/10.1556/1886.2015.00028
Fu, Ting, et al. "TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii." European journal of microbiology & immunology vol. 5,3 (2015): 221-31. doi: https://doi.org/10.1556/1886.2015.00028
Fu T, Znalesniak EB, Kalinski T, Möhle L, Biswas A, Salm F, Dunay IR, Hoffmann W. TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii. Eur J Microbiol Immunol (Bp). 2015 Sep 18;5(3):221-31. doi: 10.1556/1886.2015.00028. eCollection 2015 Sep. PMID: 26495133; PMCID: PMC4598890.
Copy Download .nbib Format: NLM
Share it on

Eur J Microbiol Immunol (Bp). 2015 Sep 18;5(3):221-31. doi: 10.1556/1886.2015.00028. eCollection 2015 Sep.

TFF Peptides Play a Role in the Immune Response Following Oral Infection of Mice with Toxoplasma Gondii.

European journal of microbiology & immunology

Ting Fu, Eva B Znalesniak, Thomas Kalinski, Luisa Möhle, Aindrila Biswas, Franz Salm, Ildiko Rita Dunay, Werner Hoffmann

Affiliations

  1. Institute of Molecular Biology and Medicinal Chemistry, Otto-von-Guericke University Magdeburg , Germany.
  2. Institute of Pathology, Otto-von-Guericke University Magdeburg , Germany.
  3. Institute of Medical Microbiology and Hygiene, Otto-von-Guericke University Magdeburg , Germany.

PMID: 26495133 PMCID: PMC4598890 DOI: 10.1556/1886.2015.00028

Abstract

The peptide trefoil factor family 3 (TFF3) is a major constituent of the intestinal mucus, playing an important role in the repair of epithelial surfaces. To further understand the role of TFF3 in the protection of intestinal epithelium, we tested the influence of TFF3 in a murine Toxoplasma gondii-induced ileitis model. Surprisingly, TFF3(KO) mice showed a reduced immune response in the ileum when compared to wild-type animals. Interleukin-12 and interferon-γ expression levels as well as the number of CD4(+) lymphocytes were reduced in the infected TFF3(KO) mice. These effects were in line with the trend of elevated parasite levels in the ileum. Moreover, TFF1 expression was upregulated in the spleen of infected mice. These initial results indicate that TFF3 is involved in the immune pathology of T. gondii infection-induced intestinal inflammation. Thus far, the mechanisms of how TFF3 influences the immune response are not fully understood. Further studies should identify if TFF3 affects mucus sensing of dendritic cells and how TFF3 is involved in regulating the immune response as an intrinsic secretory peptide of immune cells.

Keywords: FCGBP; TFF peptide; TFF1; TFF3; Toxoplasma gondii; intestinal inflammation; trefoil factor

References

  1. Am J Respir Cell Mol Biol. 2007 Mar;36(3):286-95 - PubMed
  2. Science. 2011 Oct 14;334(6053):182-3 - PubMed
  3. Invest Ophthalmol Vis Sci. 1999 Sep;40(10 ):2220-4 - PubMed
  4. Gastroenterology. 1995 Aug;109 (2):516-23 - PubMed
  5. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11017-21 - PubMed
  6. Science. 1996 Oct 11;274(5285):262-5 - PubMed
  7. Sci Signal. 2014 Apr 29;7(323):pe11 - PubMed
  8. Cell Tissue Res. 2010 Mar;339(3):639-47 - PubMed
  9. Cell Tissue Res. 2001 Jan;303(1):109-15 - PubMed
  10. J Proteome Res. 2009 Jul;8(7):3549-57 - PubMed
  11. J Immunol. 2015 Apr 1;194(7):3223-35 - PubMed
  12. J Exp Med. 2001 May 7;193(9):1027-34 - PubMed
  13. J Exp Med. 2012 Mar 12;209(3):607-22 - PubMed
  14. FEBS Lett. 1999 Jul 30;456(1):155-9 - PubMed
  15. Nat Rev Gastroenterol Hepatol. 2013 Jun;10(6):352-61 - PubMed
  16. Infect Immun. 2010 Apr;78(4):1564-70 - PubMed
  17. Regul Pept. 2005 Mar 30;126(3):163-71 - PubMed
  18. Inflammation. 2009 Apr;32(2):120-9 - PubMed
  19. Endocrinology. 2006 Dec;147(12 ):5752-9 - PubMed
  20. Infect Immun. 2007 Jan;75(1):471-80 - PubMed
  21. Curr Opin Immunol. 2010 Aug;22(4):461-6 - PubMed
  22. PLoS One. 2013 May 15;8(5):e64441 - PubMed
  23. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):6961-5 - PubMed
  24. Cell Mol Life Sci. 2009 Apr;66(8):1350-69 - PubMed
  25. J Biol Chem. 2001 Jun 29;276(26):24088-96 - PubMed
  26. Gastroenterology. 2004 Aug;127(2):502-13 - PubMed
  27. PLoS One. 2014 Sep 19;9(9):e108389 - PubMed
  28. Biochim Biophys Acta. 1999 Dec 23;1489(2-3):336-44 - PubMed
  29. Cell Physiol Biochem. 2014;34(6):1912-9 - PubMed
  30. Cell Tissue Res. 2004 May;316(2):155-65 - PubMed
  31. FASEB J. 2000 Jun;14 (9):1126-31 - PubMed
  32. Cell Tissue Res. 2007 May;328(2):365-74 - PubMed
  33. Cell Tissue Res. 2005 Jul;321(1):67-74 - PubMed
  34. Cell Physiol Biochem. 2013;32(4):997-1010 - PubMed
  35. Immunity. 2011 Aug 26;35(2):249-59 - PubMed
  36. Science. 2013 Oct 25;342(6157):447-53 - PubMed
  37. J Proteome Res. 2010 Jun 4;9(6):3108-17 - PubMed
  38. Cell Physiol Biochem. 2008;21(5-6):437-44 - PubMed
  39. EMBO J. 2013 Dec 11;32(24):3130-44 - PubMed
  40. Am J Respir Cell Mol Biol. 2004 Nov;31(5):528-37 - PubMed
  41. J Med Chem. 2009 Nov 12;52(21):6505-10 - PubMed
  42. Cell. 2014 Feb 27;156(5):1045-59 - PubMed
  43. Gastroenterology. 2008 Dec;135(6):2043-54, 2054.e1-2 - PubMed
  44. J Histochem Cytochem. 2007 May;55(5):505-13 - PubMed
  45. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):799-804 - PubMed
  46. Philos Trans R Soc Lond B Biol Sci. 1998 Jun 29;353(1370):925-33 - PubMed
  47. Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1330-5 - PubMed
  48. J Immunol. 2012 Sep 15;189(6):3078-84 - PubMed
  49. Gastroenterology. 2009 Jul;137(1):209-20 - PubMed
  50. Gastroenterology. 2004 Mar;126(3):796-808 - PubMed
  51. Immunity. 2008 Aug 15;29(2):306-17 - PubMed
  52. J Biol Chem. 2014 Oct 3;289(40):27363-75 - PubMed
  53. Science. 2013 Oct 25;342(6157):432-3 - PubMed
  54. Int J Parasitol. 2004 Mar 9;34(3):401-9 - PubMed
  55. PLoS One. 2014 Aug 20;9(8):e105120 - PubMed
  56. Arthritis Rheum. 2010 Mar;62(3):815-25 - PubMed
  57. Int Rev Cytol. 2002;213:147-81 - PubMed
  58. Int J Oncol. 2015 Sep;47(3):806-16 - PubMed
  59. Amino Acids. 2015 May;47(5):1053-63 - PubMed
  60. J Gastroenterol. 2011 May;46(5):565-76 - PubMed
  61. Cell Mol Life Sci. 2005 Dec;62(24):2947-55 - PubMed
  62. Cell Physiol Biochem. 2010;26(3):375-82 - PubMed
  63. Invest Ophthalmol Vis Sci. 2002 Nov;43(11):3359-64 - PubMed
  64. Cell Physiol Biochem. 2014;33(4):895-904 - PubMed
  65. PLoS One. 2011;6(5):e20334 - PubMed

Publication Types