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Sanaboina J, Maheswari KM, Sunkara S, et al. Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels. J Pharm (Cairo). 2013;2013:418346doi: 10.1155/2013/418346.
Sanaboina, J., Maheswari, K. M., Sunkara, S., Deekonda, S., & Nalluri, B. N. (2013). Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels. Journal of pharmaceutics, 2013418346. https://doi.org/10.1155/2013/418346
Sanaboina, Jyothi, et al. "Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels." Journal of pharmaceutics vol. 2013 (2013): 418346. doi: https://doi.org/10.1155/2013/418346
Sanaboina J, Maheswari KM, Sunkara S, Deekonda S, Nalluri BN. Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels. J Pharm (Cairo). 2013;2013:418346. doi: 10.1155/2013/418346. Epub 2013 Jan 17. PMID: 26555979; PMCID: PMC4590804.
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J Pharm (Cairo). 2013;2013:418346. doi: 10.1155/2013/418346. Epub 2013 Jan 17.

Preparation and Evaluation of Valsartan Liquid Filling Formulations for Soft Gels.

Journal of pharmaceutics

Jyothi Sanaboina, K M Maheswari, Seetha Sunkara, Sravanthi Deekonda, Buchi N Nalluri

Affiliations

  1. Department of Pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Siddhartha Nagar, Andhra Pradesh, Vijayawda 520010, India.

PMID: 26555979 PMCID: PMC4590804 DOI: 10.1155/2013/418346

Abstract

The present investigation includes the preparation of liquid filling formulations for soft gels using an antihypertensive drug, valsartan (VAL), in order to improve its dissolution properties and thereby its bioavailability. Formulations were prepared using excipients like polyethylene glycol 400 (PEG 400), propylene glycol (PG), polyvinylpyrrolidone (PVP K-30), antioxidants, ethanol, and purified water. Prepared formulations were evaluated for appearance, pH, drug content percentage, viscosity, stability, and in vitro dissolution studies. The compatibility between the drug and excipients in formulations was confirmed by FTIR spectra. The drug contents were in the range of 99.62-99.63 and the viscosity was in the range of 60.9-591.7 cps with all the formulations developed. Formulations containing 10 mg PVP K 30 gave better dissolution properties when compared to formulations without PVP K 30, and a complete drug dissolution was observed within 10 min and followed the first-order release kinetics. Stability studies were conducted for selected formulations (F4-F9) for a period of 6 months at room temperature (~30°C/65% RH). From the studies, it can be concluded that VAL liquid filling formulations for soft gels were successfully prepared with in vitro dissolution properties superior when compared to VAL itself.

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