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Deepakumari HN, Revanasiddappa HD. Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms. J Pharm (Cairo). 2012;2013:792186doi: 10.1155/2013/792186.
Deepakumari, H. N., & Revanasiddappa, H. D. (2013). Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms. Journal of pharmaceutics, 2013792186. https://doi.org/10.1155/2013/792186
Deepakumari, Hemavathi Nagaraju, and Revanasiddappa, Hosakere Doddarevanna. "Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms." Journal of pharmaceutics vol. 2013 (2013): 792186. doi: https://doi.org/10.1155/2013/792186
Deepakumari HN, Revanasiddappa HD. Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms. J Pharm (Cairo). 2013;2013:792186. doi: 10.1155/2013/792186. Epub 2012 Nov 26. PMID: 26555994; PMCID: PMC4595964.
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J Pharm (Cairo). 2013;2013:792186. doi: 10.1155/2013/792186. Epub 2012 Nov 26.

Use of the Charge Transfer Reactions for the Spectrophotometric Determination of Risperidone in Pure and in Dosage Forms.

Journal of pharmaceutics

Hemavathi Nagaraju Deepakumari, Hosakere Doddarevanna Revanasiddappa

Affiliations

  1. Department of Chemistry, University of Mysore, Manasagangothri, Mysore 570006, India.

PMID: 26555994 PMCID: PMC4595964 DOI: 10.1155/2013/792186

Abstract

The aim of study was to develop and validate two simple, sensitive, and extraction-free spectrophotometric methods for the estimation of risperidone in both pure and pharmaceutical preparations. They are based on the charge transfer complexation reactions between risperidone (RSP) as n-electron donor and p-chloranilic acid (p-CA) in method A and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in method B as π-acceptors. In method A, RSP reacts with p-CA in methanol to produce a bright pink-colored chromogen measured at 530 nm whereas, in method B, RSP reacts with DDQ in dichloromethane to form orange-colored complex with a maximum absorption at 460 nm. Beer's law was obeyed in the concentration range of 0-25 and 0-50 μg/mL with molar absorptivity of 1.29 × 10(4) and 0.48 × 10(4) L/moL/cm for RSP in methods A and B, respectively. The effects of variables such as reagents, time, and stability of the charge transfer complexes were investigated to optimize the procedures. The proposed methods have been successfully applied to the determination of RSP in pharmaceutical formulations. Results indicate that the methods are accurate, precise, and reproducible (relative standard deviation <2 %).

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