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Merlo E, Ratano P, Ilioi EC, et al. Amygdala Dopamine Receptors Are Required for the Destabilization of a Reconsolidating Appetitive Memory. eNeuro. 2015;2(1)doi: 10.1523/ENEURO.0024-14.2015.
Merlo, E., Ratano, P., Ilioi, E. C., Robbins, M. A., Everitt, B. J., & Milton, A. L. (2015). Amygdala Dopamine Receptors Are Required for the Destabilization of a Reconsolidating Appetitive Memory. eNeuro, 2(1), . https://doi.org/10.1523/ENEURO.0024-14.2015
Merlo, Emiliano, et al. "Amygdala Dopamine Receptors Are Required for the Destabilization of a Reconsolidating Appetitive Memory." eNeuro vol. 2,1 (2015). doi: https://doi.org/10.1523/ENEURO.0024-14.2015
Merlo E, Ratano P, Ilioi EC, Robbins MA, Everitt BJ, Milton AL. Amygdala Dopamine Receptors Are Required for the Destabilization of a Reconsolidating Appetitive Memory. eNeuro. 2015 Mar 06;2(1). doi: 10.1523/ENEURO.0024-14.2015. eCollection 2015. PMID: 26464966; PMCID: PMC4586917.
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eNeuro. 2015 Mar 06;2(1). doi: 10.1523/ENEURO.0024-14.2015. eCollection 2015.

Amygdala Dopamine Receptors Are Required for the Destabilization of a Reconsolidating Appetitive Memory.

eNeuro

Emiliano Merlo, Patrizia Ratano, Elena C Ilioi, Miranda A L S Robbins, Barry J Everitt, Amy L Milton

Affiliations

  1. Department of Psychology, University of Cambridge , Cambridge CB2 3EB, United Kingdom.

PMID: 26464966 PMCID: PMC4586917 DOI: 10.1523/ENEURO.0024-14.2015

Abstract

Disrupting maladaptive memories may provide a novel form of treatment for neuropsychiatric disorders, but little is known about the neurochemical mechanisms underlying the induction of lability, or destabilization, of a retrieved consolidated memory. Destabilization has been theoretically linked to the violation of expectations during memory retrieval, which, in turn, has been suggested to correlate with prediction error (PE). It is well-established that PE correlates with dopaminergic signaling in limbic forebrain structures that are critical for emotional learning. The basolateral amygdala is a key neural substrate for the reconsolidation of pavlovian reward-related memories, but the involvement of dopaminergic mechanisms in inducing lability of amygdala-dependent memories has not been investigated. Therefore, we tested the hypothesis that dopaminergic signaling within the basolateral amygdala is required for the destabilization of appetitive pavlovian memories by investigating the effects dopaminergic and protein synthesis manipulations on appetitive memory reconsolidation in rats. Intra-amygdala administration of either the D1-selective dopamine receptor antagonist SCH23390 or the D2-selective dopamine receptor antagonist raclopride prevented memory destabilization at retrieval, thereby protecting the memory from the effects of an amnestic agent, the protein synthesis inhibitor anisomycin. These data show that dopaminergic transmission within the basolateral amygdala is required for memory labilization during appetitive memory reconsolidation.

Keywords: amygdala; dopamine; reconsolidation

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