Display options
Cite
Rowley CD, Bazin PL, Tardif CL, et al. Assessing intracortical myelin in the living human brain using myelinated cortical thickness. Front Neurosci. 2015;9:396doi: 10.3389/fnins.2015.00396.
Rowley, C. D., Bazin, P. L., Tardif, C. L., Sehmbi, M., Hashim, E., Zaharieva, N., Minuzzi, L., Frey, B. N., & Bock, N. A. (2015). Assessing intracortical myelin in the living human brain using myelinated cortical thickness. Frontiers in neuroscience, 9396. https://doi.org/10.3389/fnins.2015.00396
Rowley, Christopher D, et al. "Assessing intracortical myelin in the living human brain using myelinated cortical thickness." Frontiers in neuroscience vol. 9 (2015): 396. doi: https://doi.org/10.3389/fnins.2015.00396
Rowley CD, Bazin PL, Tardif CL, Sehmbi M, Hashim E, Zaharieva N, Minuzzi L, Frey BN, Bock NA. Assessing intracortical myelin in the living human brain using myelinated cortical thickness. Front Neurosci. 2015 Oct 23;9:396. doi: 10.3389/fnins.2015.00396. eCollection 2015. PMID: 26557052; PMCID: PMC4615825.
Copy Download .nbib Format: NLM
Share it on

Front Neurosci. 2015 Oct 23;9:396. doi: 10.3389/fnins.2015.00396. eCollection 2015.

Assessing intracortical myelin in the living human brain using myelinated cortical thickness.

Frontiers in neuroscience

Christopher D Rowley, Pierre-Louis Bazin, Christine L Tardif, Manpreet Sehmbi, Eyesha Hashim, Nadejda Zaharieva, Luciano Minuzzi, Benicio N Frey, Nicholas A Bock

Affiliations

  1. Department of Psychology, Neuroscience and Behaviour, McMaster University Hamilton, ON, Canada ; MiNDS Neuroscience Graduate Program, McMaster University Hamilton, ON, Canada.
  2. Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences Leipzig, Germany.
  3. MiNDS Neuroscience Graduate Program, McMaster University Hamilton, ON, Canada ; Department of Psychiatry and Behavioural Neurosciences, McMaster University Hamilton, ON, Canada.
  4. Department of Psychology, Neuroscience and Behaviour, McMaster University Hamilton, ON, Canada.

PMID: 26557052 PMCID: PMC4615825 DOI: 10.3389/fnins.2015.00396

Abstract

Alterations in the myelination of the cerebral cortex may underlie abnormal cortical function in a variety of brain diseases. Here, we describe a technique for investigating changes in intracortical myelin in clinical populations on the basis of cortical thickness measurements with magnetic resonance imaging (MRI) at 3 Tesla. For this, we separately compute the thickness of the shallower, lightly myelinated portion of the cortex and its deeper, heavily myelinated portion (referred to herein as unmyelinated and myelinated cortex, respectively). Our expectation is that the thickness of the myelinated cortex will be a specific biomarker for disruptions in myeloarchitecture. We show representative atlases of total cortical thickness, T, unmyelinated cortical thickness, G, and myelinated cortical thickness, M, for a healthy group of 20 female subjects. We further demonstrate myelinated cortical thickness measurements in a preliminary clinical study of 10 bipolar disorder type-I subjects and 10 healthy controls, and report significant decreases in the middle frontal gyrus in T, G, and M in the disorder, with the largest percentage change occurring in M. This study highlights the potential of myelinated cortical thickness measurements for investigating intracortical myelin involvement in brain disease at clinically relevant field strengths and resolutions.

Keywords: bipolar disorder; cerebral cortex; cortical thickness; magnetic resonance imaging; myelin

References

  1. J Affect Disord. 2006 Jul;93(1-3):105-15 - PubMed
  2. Schizophr Res. 2009 Sep;113(2-3):322-31 - PubMed
  3. Neuroimage. 2015 Jul 1;114:71-87 - PubMed
  4. Cereb Cortex. 2013 Sep;23(9):2261-8 - PubMed
  5. Neuropsychopharmacology. 2015 Mar 13;40(5):1243-9 - PubMed
  6. Neuroimage. 2012 Aug 15;62(2):782-90 - PubMed
  7. Neuroimage. 2004 Nov;23(3):997-1012 - PubMed
  8. Schizophr Res. 2004 Apr 1;67(2-3):269-75 - PubMed
  9. Neurobiol Dis. 2012 Jan;45(1):37-47 - PubMed
  10. Neuroimage. 2014 Jun;93 Pt 2:201-9 - PubMed
  11. Comput Vis Image Underst. 2013 Feb 1;117(2):145-157 - PubMed
  12. J Neurosci Methods. 2009 Dec 15;185(1):15-22 - PubMed
  13. Brain Struct Funct. 2013 Mar;218(2):303-52 - PubMed
  14. Neurosci Biobehav Rev. 2014 May;42:132-47 - PubMed
  15. Neuroimage. 2015 Oct 1;119:89-102 - PubMed
  16. J Hirnforsch. 1968;10(4):285-97 - PubMed
  17. Science. 2012 Sep 14;337(6100):1357-60 - PubMed
  18. J Affect Disord. 2009 Feb;113(1-2):1-20 - PubMed
  19. J Hirnforsch. 1970;12(1):135-41 - PubMed
  20. Neuroimage. 2011 Jan 1;54(1):313-27 - PubMed
  21. J Neurochem. 2013 Nov;127(4):552-61 - PubMed
  22. Bipolar Disord. 2013 Dec;15(8):855-64 - PubMed
  23. Neural Plast. 2015;2015:708306 - PubMed
  24. Glia. 2014 Nov;62(11):1856-77 - PubMed
  25. J Hirnforsch. 1956;2(4):311-33 - PubMed
  26. J Hirnforsch. 1969;11(4):253-65 - PubMed
  27. Nat Neurosci. 2012 Mar 18;15(4):528-36 - PubMed
  28. Neuroimage. 2004 Jan;21(1):15-26 - PubMed
  29. Neuroimage. 2014 Jun;93 Pt 2:176-88 - PubMed
  30. J Affect Disord. 2013 Sep 5;150(2):192-200 - PubMed
  31. J Neurosci. 2013 Nov 20;33(47):18618-30 - PubMed
  32. Acta Psychiatr Scand. 2013 Sep;128(3):149-62 - PubMed
  33. Neuroimage. 2010 Jan 15;49(2):1271-81 - PubMed
  34. Neuroimage. 2015 May 1;111:107-22 - PubMed
  35. Bipolar Disord. 2014 Jun;16(4):378-88 - PubMed
  36. Neuroimage. 2009 Jun;46(2):432-46 - PubMed
  37. Neuroimage. 2015 Jan 15;105:473-85 - PubMed
  38. Neuroimage. 2012 Apr 2;60(2):1006-14 - PubMed
  39. Bipolar Disord. 2014 Mar;16(2):97-112 - PubMed
  40. Magn Reson Med. 2005 Mar;53(3):666-74 - PubMed
  41. Med Image Comput Comput Assist Interv. 2014;17(Pt 3):129-36 - PubMed
  42. Bipolar Disord. 2006 Feb;8(1):65-74 - PubMed
  43. Biol Psychiatry. 2013 Dec 15;74(12):908-16 - PubMed
  44. Neuroimage. 2013 Apr 15;70:122-31 - PubMed
  45. Neuroimage. 2011 Jun 15;56(4):1982-92 - PubMed
  46. Magn Reson Med. 1990 Jul;15(1):152-7 - PubMed
  47. J Int Neuropsychol Soc. 2011 Nov;17(6):1080-93 - PubMed
  48. PLoS One. 2013 Jul 16;8(7):e69294 - PubMed
  49. Mol Psychiatry. 2015 Feb;20(2):201-6 - PubMed
  50. J Comp Neurol. 1962 Apr;118:141-56 - PubMed
  51. J Am Med Inform Assoc. 2001 Sep-Oct;8(5):443-59 - PubMed
  52. Neuroimage. 2013 Jan 15;65:1-12 - PubMed
  53. J Affect Disord. 2015 Mar 15;174:342-52 - PubMed
  54. Nat Neurosci. 2012 Dec;15(12):1621-3 - PubMed
  55. Cereb Cortex. 2016 Jun;26(6):2402-10 - PubMed
  56. Brain. 2014 Apr;137(Pt 4):1224-40 - PubMed
  57. Cereb Cortex. 2015 Oct;25(10 ):3394-405 - PubMed
  58. J Neurosci. 2011 Aug 10;31(32):11597-616 - PubMed
  59. Schizophr Res. 2012 Sep;140(1-3):122-8 - PubMed
  60. Psychiatry Res. 2007 Jun 30;151(3):179-88 - PubMed
  61. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5 - PubMed

Publication Types