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Pyati AK, Devaranavadagi BB, Sajjannar SL, et al. Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction. J Clin Diagn Res. 2015;9(10):BC08-11doi: 10.7860/JCDR/2015/15132.6684.
Pyati, A. K., Devaranavadagi, B. B., Sajjannar, S. L., Nikam, S. V., Shannawaz, M., & Sudharani. (2015). Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction. Journal of clinical and diagnostic research : JCDR, 9(10), BC08-11. https://doi.org/10.7860/JCDR/2015/15132.6684
Pyati, Anand K, et al. "Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction." Journal of clinical and diagnostic research : JCDR vol. 9,10 (2015): BC08-11. doi: https://doi.org/10.7860/JCDR/2015/15132.6684
Pyati AK, Devaranavadagi BB, Sajjannar SL, Nikam SV, Shannawaz M, Sudharani. Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction. J Clin Diagn Res. 2015 Oct;9(10):BC08-11. doi: 10.7860/JCDR/2015/15132.6684. Epub 2015 Oct 01. PMID: 26557510; PMCID: PMC4625229.
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J Clin Diagn Res. 2015 Oct;9(10):BC08-11. doi: 10.7860/JCDR/2015/15132.6684. Epub 2015 Oct 01.

Heart-Type Fatty Acid Binding Protein: A Better Cardiac Biomarker than CK-MB and Myoglobin in the Early Diagnosis of Acute Myocardial Infarction.

Journal of clinical and diagnostic research : JCDR

Anand K Pyati, Basavaraj B Devaranavadagi, Sanjeev L Sajjannar, Shashikant V Nikam, Mohd Shannawaz, Sudharani

Affiliations

  1. Ph.D Scholar, Department of Biochemistry, BLDE University's Shri B M Patil Medical College, Hospital & Research Centre , Vijayapur, Karnataka, India .
  2. Professor and Head, Department of Biochemistry, BLDE University's Shri B M Patil Medical College, Hospital & Research Centre , Vijayapur, Karnataka, India .
  3. Assistant Professor, Department of Cardiology, BLDE University's Shri B M Patil Medical College , Hospital & Research Centre, Vijayapur, Karnataka, India .
  4. Professor and Head, Department of Biochemistry, Belagavi Institute of Medical Sciences , Belagavi, Karnataka, India .
  5. Lecturer, Statistics, Department of Community Medicine, BLDE University's Shri B M Patil Medical College, Hospital & Research Centre , Vijayapur, Karnataka, India .
  6. Post Graduate Student, Department of Pedodontics and Preventive Dentistry, Navodaya Dental College , Raichur, India .

PMID: 26557510 PMCID: PMC4625229 DOI: 10.7860/JCDR/2015/15132.6684

Abstract

BACKGROUND: Early diagnosis and therapeutic intervention can improve the outcome of acute myocardial infarction (AMI). However, there are no satisfactory cardiac biomarkers for the diagnosis of AMI within 6 hours of onset of symptoms. Among novel biochemical markers of AMI, heart-type fatty acid binding protein (H-FABP) is of particular interest.

AIM: To compare the diagnostic value of H-FABP with that of CK-MB and myoglobin in suspected AMI patients within first 6 hours after the onset of symptoms.

SETTINGS AND DESIGN: The study includes 40 AMI cases and 40 non-cardiac chest pain otherwise healthy controls. The cases and controls were further divided into 2 groups depending on the time since chest pain as those subjects within 3 hours and those between 3-6 hours of onset of chest pain.

MATERIALS AND METHODS: In all the cases and controls, serum H-FABP, CK-MB and myoglobin concentrations were measured by Immunoturbidimetric method, immuno-inhibition method and Chemiluminescence immunoassay respectively.

STATISTICAL ANALYSIS: Data is presented as mean ± SD values. Differences between means of two groups were assessed by Student t-test. Sensitivity, Specificity, Positive predictive value, Negative predictive values were calculated and ROC curve analysis was done to assess the diagnostic validity of each study parameter.

RESULTS: The sensitivity, specificity, PPV, NPV of H-FABP were greater than CK-MB and myoglobin and ROC curve analysis demonstrated highest area under curve for H-FABP followed by myoglobin and CK-MB in patients with suspected AMI both within 3 hours and 3-6 hours after the onset of chest pain.

CONCLUSION: The diagnostic efficiency of H-FABP is greater than CK-MB and myoglobin for the early diagnosis of AMI within first 6 hours of chest pain. H-FABP can be used as an additional diagnostic tool for the early diagnosis of AMI.

Keywords: Chest pain; Diagnostic validity; Immunoturbidimetric method; ROC analysis; Sensitivity

References

  1. Can Fam Physician. 2007 Feb;53(2):261-6 - PubMed
  2. Am J Emerg Med. 2006 Mar;24(2):149-55 - PubMed
  3. Clin Chem. 2001 Mar;47(3):587-8 - PubMed
  4. J Korean Med Sci. 2011 Jan;26(1):47-52 - PubMed
  5. Ann Clin Biochem. 2009 Nov;46(Pt 6):464-7 - PubMed
  6. Eur Heart J. 2008 Dec;29(23):2827-8 - PubMed
  7. Indian J Community Med. 2009 Oct;34(4):293-7 - PubMed
  8. Sultan Qaboos Univ Med J. 2010 Apr;10(1):41-9 - PubMed
  9. Emerg Med J. 2005 Jul;22(7):486-9 - PubMed
  10. J Huazhong Univ Sci Technolog Med Sci. 2004;24(5):449-51, 459 - PubMed
  11. Clin Chim Acta. 1998 Apr 6;272(1):87-92 - PubMed
  12. Forensic Sci Int. 2006 Jun 27;160(1):11-6 - PubMed
  13. Am J Clin Pathol. 2010 Jul;134(1):157-62 - PubMed
  14. Circulation. 2001 Nov 27;104(22):2746-53 - PubMed
  15. Am J Emerg Med. 2010 Oct;28(8):891-6 - PubMed
  16. Heart. 2003 Mar;89(3):280-6 - PubMed
  17. Ann Clin Lab Sci. 1996 Jul-Aug;26(4):291-300 - PubMed
  18. Am J Emerg Med. 2012 Feb;30(2):267-74 - PubMed
  19. BMJ. 1993 Aug 14;307(6901):409-13 - PubMed
  20. Circ J. 2004 Jul;68(7):639-44 - PubMed
  21. QJM. 2004 Apr;97(4):187-98 - PubMed

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