Display options
Cite
Neumann H, Neurath MF, Atreya R. Endoscopic Therapy in Inflammatory Bowel Diseases. Viszeralmedizin. 2015;31(4):280-6doi: 10.1159/000435851.
Neumann, H., Neurath, M. F., & Atreya, R. (2015). Endoscopic Therapy in Inflammatory Bowel Diseases. Viszeralmedizin, 31(4), 280-6. https://doi.org/10.1159/000435851
Neumann, Helmut, et al. "Endoscopic Therapy in Inflammatory Bowel Diseases." Viszeralmedizin vol. 31,4 (2015): 280-6. doi: https://doi.org/10.1159/000435851
Neumann H, Neurath MF, Atreya R. Endoscopic Therapy in Inflammatory Bowel Diseases. Viszeralmedizin. 2015 Aug;31(4):280-6. doi: 10.1159/000435851. Epub 2015 Aug 04. PMID: 26557837; PMCID: PMC4608609.
Copy Download .nbib Format: NLM
Share it on

Viszeralmedizin. 2015 Aug;31(4):280-6. doi: 10.1159/000435851. Epub 2015 Aug 04.

Endoscopic Therapy in Inflammatory Bowel Diseases.

Viszeralmedizin

Helmut Neumann, Markus F Neurath, Raja Atreya

Affiliations

  1. Medical Clinic I, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.

PMID: 26557837 PMCID: PMC4608609 DOI: 10.1159/000435851

Abstract

BACKGROUND: Endoscopy is an essential diagnostic and therapeutic modality in the clinical care of inflammatory bowel disease (IBD) patients. Endoscopic therapy can be used for treatment of disease-related strictures, surveillance and resection of intraepithelial neoplasia, and treatment of fistulas or disease-related complications, and is currently being evaluated regarding its capacity in in vivo molecular imaging procedures.

METHODS: A literature search using Medline and Science Citation Index was performed in March 2015. All studies on endoscopic therapy in IBD published from 1980 to 2015 (March) were reviewed. Potential studies were initially screened by title and abstract. The terms 'endoscopy IBD', 'endoscopy therapy IBD', 'dilatation IBD', 'strictureplasty Crohn's disease', 'endoscopy therapy fistula', 'endoscopy toxic megacolon', 'endoscopy dysplasia IBD', 'endoscopy complications IBD', and 'molecular imaging IBD' were used in the search. A total of 115 articles were studied to construct this review.

RESULTS: Dilatation is most useful in short anastomotic strictures, but can be also undertaken in colonic strictures. Strictures in ulcerative colitis are always suspicious for neoplasia and should be evaluated carefully. Lesions with intraepithelial neoplasia can be resected when complete removal can be assured. The finding of carcinoma or high-grade dysplasia in a random biopsy is an indication for colectomy. If intraepithelial neoplasia is present in random biopsy specimens, colectomy should similarly be recommended. Endoscopic therapy of Crohn's fistulas is a possible emerging technology. In vivo molecular imaging is currently being studied in IBD patients and offers promising therapeutic opportunities.

CONCLUSION: Therapeutic endoscopy is indispensable in the management of IBD. It has to be carefully evaluated against alternative surgical options but often offers an effective therapeutic approach. © 2015 S. Karger GmbH, Freiburg.

Keywords: Crohn's disease; Endoscopic therapy; Endoscopy; Inflammatory bowel diseases; Ulcerative colitis

References

  1. Gastrointest Endosc. 2006 Apr;63(4):558-65 - PubMed
  2. Gut. 2001 Apr;48(4):526-35 - PubMed
  3. Gastroenterology. 2003 Nov;125(5):1508-30 - PubMed
  4. Gastroenterology. 1994 Oct;107(4):934-44 - PubMed
  5. Gastroenterology. 2007 Mar;132(3):874-82 - PubMed
  6. Nat Rev Gastroenterol Hepatol. 2013 Oct;10(10):585-95 - PubMed
  7. Gastroenterology. 2010 Aug;139(2):388-92, 392.e1-2 - PubMed
  8. N Engl J Med. 2002 Aug 8;347(6):417-29 - PubMed
  9. Clin Gastroenterol Hepatol. 2015 Feb;13(2):322-329.e1 - PubMed
  10. Gastroenterology. 2012 Aug;143(2):375-81.e1; quiz e13-4 - PubMed
  11. Nat Rev Gastroenterol Hepatol. 2013 Dec;10(12):704-12 - PubMed
  12. Lancet. 2007 May 12;369(9573):1641-57 - PubMed
  13. Int J Colorectal Dis. 2013 Mar;28(3):313-23 - PubMed
  14. Endoscopy. 2002 Aug;34(8):632-8 - PubMed
  15. Gastroenterology. 2006 Apr;130(4):1030-8 - PubMed
  16. Dig Dis. 2009;27(4):576-83 - PubMed
  17. J Clin Invest. 2007 Mar;117(3):514-21 - PubMed
  18. Am J Gastroenterol. 1987 Jul;82(7):692-4 - PubMed
  19. J Gastroenterol. 1995 Nov;30 Suppl 8:36-9 - PubMed
  20. Gastroenterol Clin North Am. 2006 Sep;35(3):533-52 - PubMed
  21. Clin Gastroenterol Hepatol. 2007 Sep;5(9):1065-9 - PubMed
  22. Clin Gastroenterol Hepatol. 2009 Jun;7(6):641-52 - PubMed
  23. Gastroenterol Hepatol (N Y). 2013 Sep;9(9):573-83 - PubMed
  24. Gastrointest Endosc. 2013 Dec;78(6):819-35 - PubMed
  25. Endoscopy. 2003 Apr;35(4):333-7 - PubMed
  26. Inflamm Bowel Dis. 2009 Apr;15(4):630-8 - PubMed
  27. Dis Colon Rectum. 2012 Jul;55(7):762-72 - PubMed
  28. Dis Colon Rectum. 2007 Nov;50(11):1968-86 - PubMed
  29. Intest Res. 2015 Jan;13(1):19-26 - PubMed
  30. Gastroenterology. 1991 May;100(5 Pt 1):1241-8 - PubMed
  31. Gut. 2004 Feb;53(2):256-60 - PubMed
  32. Dis Colon Rectum. 2004 Apr;47(4):432-6 - PubMed
  33. J Crohns Colitis. 2011 Jun;5(3):189-95 - PubMed
  34. Gastroenterology. 2003 Apr;124(4):880-8 - PubMed
  35. Gastrointest Endosc. 2012 Dec;76(6):1251-5 - PubMed
  36. Gut. 2006 Aug;55(8):1151-5 - PubMed
  37. Am J Gastroenterol. 1999 Aug;94(8):2177-81 - PubMed
  38. Acta Biomed. 2005 Sep;76(2):95-8 - PubMed
  39. Gastroenterology. 2004 May;126(6):1504-17 - PubMed
  40. Gastroenterology. 2010 Feb;138(2):738-45 - PubMed
  41. Gastrointest Endosc. 1999 Feb;49(2):153-7 - PubMed
  42. Nihon Shokakibyo Gakkai Zasshi. 1991 Jan;88(1):91-5 - PubMed
  43. Lancet. 1994 Jan 8;343(8889):71-4 - PubMed
  44. Endoscopy. 2009 May;41(5):468-71 - PubMed
  45. Dig Endosc. 2014 Jul;26(4):545-51 - PubMed
  46. Aliment Pharmacol Ther. 2012 Nov;36(9):833-9 - PubMed
  47. Gut. 2003 Aug;52(8):1127-32 - PubMed
  48. Hepatogastroenterology. 1989 Aug;36(4):219-26 - PubMed
  49. Inflamm Bowel Dis. 2013 Sep;19(10):2132-8 - PubMed
  50. Clin Gastroenterol Hepatol. 2004 Jul;2(7):534-41 - PubMed
  51. Gastroenterology. 2009 May;136(5):1561-7; quiz 1818-9 - PubMed
  52. Gastrointest Endosc. 2004 Sep;60(3):334-9 - PubMed
  53. Gastroenterology. 1999 Dec;117(6):1288-94; discussion 1488-91 - PubMed
  54. World J Gastroenterol. 2011 Jan 7;17(1):63-8 - PubMed
  55. Nat Med. 2014 Mar;20(3):313-8 - PubMed
  56. Cancer. 2001 Feb 15;91(4):854-62 - PubMed
  57. Am J Gastroenterol. 1999 Jul;94(7):1746-50 - PubMed
  58. Gastroenterology. 2006 Jun;130(7):1941-9 - PubMed
  59. Aliment Pharmacol Ther. 2007 Dec;26(11-12):1457-64 - PubMed
  60. Nat Rev Immunol. 2014 May;14(5):329-42 - PubMed
  61. Gastroenterology. 2013 Jul;145(1):166-175.e8 - PubMed
  62. Aliment Pharmacol Ther. 2006 Apr 15;23(8):1097-104 - PubMed
  63. Endoscopy. 2011 Oct;43(10):911-7 - PubMed
  64. Endoscopy. 2014 Dec;46(12):1106-9 - PubMed
  65. Hum Pathol. 1983 Nov;14 (11):931-68 - PubMed
  66. Gut. 1980 Jun;21(6):525-7 - PubMed
  67. Langenbecks Arch Surg. 2006 Aug;391(4):435-8 - PubMed
  68. J Crohns Colitis. 2013 Dec;7(12):982-1018 - PubMed
  69. Inflamm Bowel Dis. 2005 Mar;11(3):314-21 - PubMed
  70. Histopathology. 1988 Oct;13(4):385-97 - PubMed

Publication Types