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Ha F, Khalil H. Crohn's disease: a clinical update. Therap Adv Gastroenterol. 2015;8(6):352-9doi: 10.1177/1756283X15592585.
Ha, F., & Khalil, H. (2015). Crohn's disease: a clinical update. Therapeutic advances in gastroenterology, 8(6), 352-9. https://doi.org/10.1177/1756283X15592585
Ha, Francis, and Khalil, Hanan. "Crohn's disease: a clinical update." Therapeutic advances in gastroenterology vol. 8,6 (2015): 352-9. doi: https://doi.org/10.1177/1756283X15592585
Ha F, Khalil H. Crohn's disease: a clinical update. Therap Adv Gastroenterol. 2015 Nov;8(6):352-9. doi: 10.1177/1756283X15592585. PMID: 26557891; PMCID: PMC4622286.
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Therap Adv Gastroenterol. 2015 Nov;8(6):352-9. doi: 10.1177/1756283X15592585.

Crohn's disease: a clinical update.

Therapeutic advances in gastroenterology

Francis Ha, Hanan Khalil

Affiliations

  1. Faculty of Medicine, Nursing and Health Science, Monash University, Australia.
  2. School of Rural Health, Monash University, Ollerton Rd, Moe, Victoria, Australia.

PMID: 26557891 PMCID: PMC4622286 DOI: 10.1177/1756283X15592585

Abstract

Crohn's disease is increasing in prevalence worldwide. It arises from a complex interplay between both genetic predisposition and environmental influence. A search of databases and clinical practice guidelines was performed to provide the most up-to-date evidence-based approach for diagnosing and managing patients with Crohn's disease. No single gold standard investigation exists. Whilst full ileocolonoscopy with biopsies remains the mainstay for diagnosis, other less invasive imaging modalities are being actively considered in the workup, as well as the use of serological markers. Management should incorporate dietary and lifestyle modifications where necessary, the use of medications in induction and remission of disease, and consideration of surgical intervention where medical therapy has failed.

Keywords: Crohn’s disease; colorectal cancer; diagnosis; inflammatory bowel disease; investigations; management; risk factors

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