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Ip S, Jeong R, Schaeffer DF, et al. Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate. World J Hepatol. 2015;7(24):2559-62doi: 10.4254/wjh.v7.i24.2559.
Ip, S., Jeong, R., Schaeffer, D. F., & Yoshida, E. M. (2015). Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate. World journal of hepatology, 7(24), 2559-62. https://doi.org/10.4254/wjh.v7.i24.2559
Ip, Stephen, et al. "Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate." World journal of hepatology vol. 7,24 (2015): 2559-62. doi: https://doi.org/10.4254/wjh.v7.i24.2559
Ip S, Jeong R, Schaeffer DF, Yoshida EM. Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate. World J Hepatol. 2015 Oct 28;7(24):2559-62. doi: 10.4254/wjh.v7.i24.2559. PMID: 26527309; PMCID: PMC4621470.
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World J Hepatol. 2015 Oct 28;7(24):2559-62. doi: 10.4254/wjh.v7.i24.2559.

Unusual case of drug-induced cholestasis due to glucosamine and chondroitin sulfate.

World journal of hepatology

Stephen Ip, Rachel Jeong, David F Schaeffer, Eric M Yoshida

Affiliations

  1. Stephen Ip, Eric M Yoshida, Division of Gastroenterology, Vancouver General Hospital, University of British Columbia, Vancouver, British Columbia V5Z 1M9, Canada.

PMID: 26527309 PMCID: PMC4621470 DOI: 10.4254/wjh.v7.i24.2559

Abstract

Glucosamine (GS) and chondroitin sulfate (CS) are common over-the-counter (OTC) supplements used in the treatment of osteoarthritis. These medications are seemingly safe, but there are increasing reports of hepatotoxicity with these supplements. We reported a unique case of drug-induced cholestasis caused by GS and CS in a combination tablet. The etiology of the jaundice was overlooked despite extensive investigations over a three-month period. Unlike drug-induced hepatocellular injury, drug-induced cholestatic jaundice with GS and CS has only been reported twice before. This case emphasizes the importance of a complete medication history, especially OTC supplements, in the assessment of cholestasis.

Keywords: Cholestasis; Chondroitin; Glucosamine; Hepatotoxicity; Jaundice

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