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Albersen M, Lin CS, Lue T. Stem-cell therapy for erectile dysfunction. Arab J Urol. 2013;11(3):237-44doi: 10.1016/j.aju.2013.05.005.
Albersen, M., Lin, C. S., & Lue, T. (2013). Stem-cell therapy for erectile dysfunction. Arab journal of urology, 11(3), 237-44. https://doi.org/10.1016/j.aju.2013.05.005
Albersen, Maarten, et al. "Stem-cell therapy for erectile dysfunction." Arab journal of urology vol. 11,3 (2013): 237-44. doi: https://doi.org/10.1016/j.aju.2013.05.005
Albersen M, Lin CS, Lue T. Stem-cell therapy for erectile dysfunction. Arab J Urol. 2013 Sep;11(3):237-44. doi: 10.1016/j.aju.2013.05.005. Epub 2013 Sep 12. PMID: 26558088; PMCID: PMC4442996.
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Arab J Urol. 2013 Sep;11(3):237-44. doi: 10.1016/j.aju.2013.05.005. Epub 2013 Sep 12.

Stem-cell therapy for erectile dysfunction.

Arab journal of urology

Maarten Albersen, Ching-Shwun Lin, Tom Lue

Affiliations

  1. Laboratory for Experimental Urology, Gene and Stem Cells Applications, Department of Development and Regeneration, University of Leuven, Leuven, Belgium.
  2. Knuppe Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, CA, USA.

PMID: 26558088 PMCID: PMC4442996 DOI: 10.1016/j.aju.2013.05.005

Abstract

INTRODUCTION: Erectile dysfunction (ED) is the most common sexual disorder that men report to healthcare providers, and is the male sexual dysfunction that has been most investigated. Current treatments for ED focus on relieving the symptoms of ED and therefore tend to provide a temporary solution rather than a cure or reversing the cause. Recently, therapies based on stem cells (SCs) have had an increasing attention for their potential to restore erectile function. Preclinical studies showed that these cells might reverse the pathophysiological changes leading to ED, rather than treating the symptoms of ED. This review is intended to provide an overview of contemporary reports on the use of SCs to treat ED.

METHODS: We made an extensive search for reports on SC-based therapy for the management of ED, published in English between 1966 and 2013, using the search engines SciVerse-sciencedirect, SciVerse-scopus, Google Scholar and Pubmed, with the search terms 'erectile dysfunction', 'stem cells', 'multipotent stromal cells', 'adipose (tissue) derived stem cells', 'bone-marrow derived stem cells', 'animal model', 'diabetes', 'ageing', 'Peyronie's Disease' and 'cavernous nerve injury'.

RESULTS: Fifty-four papers were identified and contributed, either as an original research report or review thereof, to this review. Several preclinical studies addressed SC-based therapies for the recovery of erectile function caused by a variety of both chronic and acute conditions. Overall, these studies showed beneficial effects of SC therapy, while evidence on the mechanisms of action of SC therapy varied between studies. One clinical trial investigated the short-term effects of SC therapy in diabetic patients with ED. Two more clinical trials are currently recruiting patients.

CONCLUSIONS: The rapidly expanding and highly promising body of preclinical work on SC-based medicine providing a potential cure for ED, rather than merely symptom relief, is indicative of the increasing interest in regenerative options for sexual medicine over the past decade. Clinical trials are currently recruiting patients to test the preclinical results in men with ED.

Keywords: (A)(E)(H)(M) SC, (adult) (embryonic) (haematopoietic) (mesenchymal) stem cell; (e)(n)NOS, (endothelial) (neuronal) NO synthase; AD, adipose tissue-derived; Ageing; BM, bone marrow-derived; CC, corpus cavernosum; CNI, cavernous nerve injury; Cavernous nerve injury; Diabetes; ED, erectile dysfunction; GFP, green fluorescent protein; MD, muscle-derived; MPG, major pelvic ganglion; NO, nitric oxide; PD, Peyronie’s disease; PDE5 (I), phosphodiesterase type 5 (inhibitor); Peyronie’s disease; RP, radical prostatectomy; SVF, stromal vascular fraction

References

  1. J Sex Med. 2011 Feb;8(2):427-36 - PubMed
  2. J Sex Med. 2012 Nov;9(11):2770-84 - PubMed
  3. BJU Int. 2008 May;101(9):1156-64 - PubMed
  4. Cardiol Rev. 2011 Jan-Feb;19(1):5-11 - PubMed
  5. BJU Int. 2004 Oct;94(6):904-9 - PubMed
  6. World J Stem Cells. 2011 Apr 26;3(4):25-33 - PubMed
  7. Eur Urol. 2007 Jan;51(1):75-88; discussion 89 - PubMed
  8. Int J Androl. 2012 Aug;35(4):601-7 - PubMed
  9. J Sex Med. 2012 Aug;9(8):1968-79 - PubMed
  10. Eur Urol. 2013 Mar;63(3):551-60 - PubMed
  11. Stem Cells. 2011 May;29(5):749-54 - PubMed
  12. Nat Rev Urol. 2012 Sep;9(9):520-36 - PubMed
  13. Tissue Eng Part A. 2013 Jan;19(1-2):14-23 - PubMed
  14. Adv Urol. 2008;:594868 - PubMed
  15. Cell Mol Neurobiol. 2013 Mar;33(2):233-40 - PubMed
  16. Surgery. 2008 May;143(5):577-81 - PubMed
  17. JAMA. 1993 Jul 7;270(1):83-90 - PubMed
  18. Int J Impot Res. 1996 Jun;8(2):47-52 - PubMed
  19. J Sex Med. 2010 Jan;7(1 Pt 1):89-98 - PubMed
  20. Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1278-90 - PubMed
  21. Eur Urol. 2013 Mar;63(3):561-2 - PubMed
  22. Mol Ther. 2009 Jul;17(7):1250-6 - PubMed
  23. J Sex Med. 2010 Apr;7(4 Pt 1):1391-400 - PubMed
  24. Prostate. 2013 Feb 15;73(3):278-86 - PubMed
  25. Cytotherapy. 2006;8(4):315-7 - PubMed
  26. Expert Opin Emerg Drugs. 2010 Sep;15(3):467-80 - PubMed
  27. J Sex Med. 2012 Feb;9(2):482-93 - PubMed
  28. Int Braz J Urol. 2012 Nov-Dec;38(6):833-41 - PubMed
  29. Curr Stem Cell Res Ther. 2010 Jun;5(2):103-10 - PubMed
  30. Eur Urol. 2012 Oct;62(4):720-7 - PubMed
  31. Gene Ther. 2002 May;9(10):642-7 - PubMed
  32. Exp Clin Transplant. 2010 Jun;8(2):150-60 - PubMed
  33. J Sex Med. 2012 Dec;9(12):3051-65 - PubMed
  34. Regen Med. 2010 Jan;5(1):121-43 - PubMed
  35. Eur Urol. 2009 Oct;56(4):716-25 - PubMed
  36. J Urol. 2011 Mar;185(3):1158-9; author reply 1159-61 - PubMed
  37. J Sex Med. 2010 Oct;7(10):3331-40 - PubMed
  38. Int J Impot Res. 2011 Nov-Dec;23(6):268-75 - PubMed
  39. J Sex Med. 2013 Jan;10(1):195-203 - PubMed
  40. J Sex Med. 2012 Jul;9(7):1834-41 - PubMed
  41. Int J Impot Res. 2006 Jul-Aug;18(4):329-34 - PubMed
  42. J Urol. 1998 May;159(5):1541-7 - PubMed
  43. Urology. 2013 Jan;81(1):104-10 - PubMed
  44. Asian J Androl. 2012 Jan;14(1):145-55 - PubMed
  45. J Androl. 2012 Jan-Feb;33(1):37-44 - PubMed
  46. J Urol. 2010 Oct;184(4):1560-6 - PubMed
  47. Andrologia. 2010 Jun;42(3):187-92 - PubMed
  48. J Sex Med. 2010 Jan;7(1 Pt 2):445-75 - PubMed
  49. J Sex Med. 2013 May;10 (5):1268-77 - PubMed
  50. J Sex Med. 2011 Feb;8(2):437-46 - PubMed
  51. Korean J Urol. 2011 May;52(5):359-63 - PubMed
  52. Eur Urol. 2012 Jan;61(1):201-10 - PubMed
  53. J Sex Med. 2012 Feb;9(2):385-403 - PubMed

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