Front Pharmacol. 2015 Oct 16;6:222. doi: 10.3389/fphar.2015.00222. eCollection 2015.
Frontiers in pharmacology
Handrean Soran, Jonathan D Schofield, Paul N Durrington
PMID: 26528181 PMCID: PMC4607861 DOI: 10.3389/fphar.2015.00222
High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly, HDL actually metabolizes lipid hydroperoxides preventing their accumulation on low-density lipoprotein (LDL), thus impeding its atherogenic structural modification. A number of candidates have been suggested to be responsible for HDL's antioxidant function, with paraoxonase-1 (PON1) perhaps the most prominent. Here we review the evidence for HDL anti-oxidative function and the potential contributions of apolipoproteins, lipid transfer proteins, paraoxonases and other enzymes associated with HDL.
Keywords: apolipoprotein A1; glycated low-density lipoprotein; high-density lipoprotein; oxidized low-density lipoprotein; paraoxonase 1