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Altara R, Manca M, Sabra R, et al. Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine. Heart Fail Rev. 2016;21(1):25-47doi: 10.1007/s10741-015-9513-8.
Altara, R., Manca, M., Sabra, R., Eid, A. A., Booz, G. W., & Zouein, F. A. (2016). Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine. Heart failure reviews, 21(1), 25-47. https://doi.org/10.1007/s10741-015-9513-8
Altara, Raffaele, et al. "Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine." Heart failure reviews vol. 21,1 (2016): 25-47. doi: https://doi.org/10.1007/s10741-015-9513-8
Altara R, Manca M, Sabra R, Eid AA, Booz GW, Zouein FA. Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine. Heart Fail Rev. 2016 Jan;21(1):25-47. doi: 10.1007/s10741-015-9513-8. PMID: 26498937.
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Heart Fail Rev. 2016 Jan;21(1):25-47. doi: 10.1007/s10741-015-9513-8.

Temporal cardiac remodeling post-myocardial infarction: dynamics and prognostic implications in personalized medicine.

Heart failure reviews

Raffaele Altara, Marco Manca, Ramzi Sabra, Assaad A Eid, George W Booz, Fouad A Zouein

Affiliations

  1. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
  2. Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
  3. DG-DI, Medical Applications, CERN, Geneva, Switzerland.
  4. Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  5. Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  6. Department of Pharmacology and Toxicology, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. [email protected].
  7. Department of Pharmacology and Toxicology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. [email protected].

PMID: 26498937 DOI: 10.1007/s10741-015-9513-8

Abstract

Despite dramatic improvements in short-term mortality rates following myocardial infarction (MI), long-term survival for MI patients who progress to heart failure remains poor. MI occurs when the left ventricle (LV) is deprived of oxygen for a sufficient period of time to induce irreversible necrosis of the myocardium. The LV response to MI involves significant tissue, cellular, and molecular level modifications, as well as substantial hemodynamic changes that feedback negatively to amplify the response. Inflammation to remove necrotic myocytes and fibroblast activation to form a scar are key wound healing responses that are highly variable across individuals. Few biomarkers of early remodeling stages are currently clinically adopted. The discovery of underlying pathophysiological mechanisms and associated novel biomarkers has the potential of improving prognostic capability and therapeutic monitoring. Combining these biomarkers with other prominent ones could constitute a powerful diagnostic and prognostic tool that directly reflects the pathophysiological remodeling of the LV. Understanding temporal remodeling at the tissue, cellular, and molecular level and its link to a well-defined set of biomarkers at early stages post-MI is a prerequisite for improving personalized care and devising more successful therapeutic interventions. Here we summarize the integral mechanisms that occur during early cardiac remodeling in the post-MI setting and highlight the most prominent biomarkers for assessing disease progression.

Keywords: Biomarkers; Cardiac remodeling; Extracellular matrix; Inflammation; Myocardial infarction; Personalized medicine

References

  1. J Am Coll Cardiol. 2003 Apr 16;41(8):1264-72 - PubMed
  2. J Leukoc Biol. 2003 Jul;74(1):88-94 - PubMed
  3. Cancer Res. 2008 May 1;68(9):3405-12 - PubMed
  4. Can J Cardiol. 2010 Aug-Sep;26(7):e243-8 - PubMed
  5. Eur J Heart Fail. 2008 Feb;10(2):133-9 - PubMed
  6. Cardiovasc Res. 2000 May;46(2):307-15 - PubMed
  7. Braz J Med Biol Res. 1994 Nov;27(11):2667-79 - PubMed
  8. Nat Rev Mol Cell Biol. 2002 May;3(5):349-63 - PubMed
  9. Cytobios. 1980;28(109):41-61 - PubMed
  10. Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):77-83 - PubMed
  11. J Clin Invest. 2012 Apr;122(4):1427-43 - PubMed
  12. J Am Coll Cardiol. 2005 Dec 6;46(11):2116-24 - PubMed
  13. J Mol Cell Cardiol. 2012 Aug;53(2):250-8 - PubMed
  14. Coron Artery Dis. 2010 May;21(3):129-36 - PubMed
  15. Neurosci Lett. 1995 Dec 15;201(3):223-6 - PubMed
  16. Cardiovasc Res. 2004 Aug 15;63(3):423-32 - PubMed
  17. Cardiovasc Res. 2009 Feb 15;81(3):474-81 - PubMed
  18. J Mol Cell Cardiol. 2010 Jun;48(6):1071-9 - PubMed
  19. J Am Coll Cardiol. 2007 Sep 11;50(11):1054-60 - PubMed
  20. N Engl J Med. 1999 Sep 2;341(10):738-46 - PubMed
  21. J Pathol. 2008 Jan;214(2):161-78 - PubMed
  22. Science. 2009 Jun 26;324(5935):1710-3 - PubMed
  23. Cell Mol Life Sci. 2005 Nov;62(22):2549-59 - PubMed
  24. Circ Res. 2012 Mar 16;110(6):851-6 - PubMed
  25. Circ Res. 2010 Apr 16;106(7):1275-84 - PubMed
  26. Cancer Res. 1996 Jun 15;56(12):2707-10 - PubMed
  27. J Mol Med (Berl). 2005 Aug;83(8):626-37 - PubMed
  28. Cardiology. 2011;118(4):217-26 - PubMed
  29. Vasc Health Risk Manag. 2010 Sep 07;6:691-9 - PubMed
  30. Genet Mol Res. 2015 Apr 27;14 (2):4027-34 - PubMed
  31. Circulation. 2007 Oct 2;116(14):1540-8 - PubMed
  32. Biochem Biophys Res Commun. 1997 Jan 3;230(1):202-5 - PubMed
  33. Am J Physiol Heart Circ Physiol. 2001 Aug;281(2):H543-51 - PubMed
  34. Circ Res. 2000 May 12;86(9):939-45 - PubMed
  35. Clin Exp Immunol. 1995 Jul;101 Suppl 1:6-9 - PubMed
  36. Circulation. 1998 May 5;97(17):1708-15 - PubMed
  37. Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H590-8 - PubMed
  38. Life Sci. 2001 Jan 5;68(7):799-814 - PubMed
  39. J Clin Invest. 1996 Dec 15;98(12):2854-65 - PubMed
  40. J Mol Cell Cardiol. 1998 Jul;30(7):1431-42 - PubMed
  41. BMJ. 2015 Jan 20;350:h15 - PubMed
  42. Am J Pathol. 1994 Dec;145(6):1450-62 - PubMed
  43. Cardiovasc Pathol. 2009 Jan-Feb;18(1):37-43 - PubMed
  44. Circulation. 2004 Oct 5;110(14 ):1933-9 - PubMed
  45. Heart. 2009 Mar;95(3):191-7 - PubMed
  46. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1072-8 - PubMed
  47. Eur J Pharmacol. 2003 Feb 7;461(1):49-52 - PubMed
  48. Eur Heart J. 2008 May;29(9):1096-102 - PubMed
  49. J Leukoc Biol. 1995 May;57(5):774-7 - PubMed
  50. Pharmacol Ther. 2013 Jul;139(1):32-40 - PubMed
  51. Circulation. 2007 Apr 24;115(16):2103-10 - PubMed
  52. Circ Res. 1997 Nov;81(5):785-96 - PubMed
  53. Eur Cytokine Netw. 2005 Jun;16(2):152-60 - PubMed
  54. J Cell Biol. 1982 Oct;95(1):351-4 - PubMed
  55. Circulation. 2007 Jan 30;115(4):475-82 - PubMed
  56. Nat Med. 2007 Aug;13(8):952-61 - PubMed
  57. Nat Rev Immunol. 2006 Jul;6(7):541-50 - PubMed
  58. J Clin Invest. 2010 Nov;120(11):4141-54 - PubMed
  59. Matrix Biol. 2010 Sep;29(7):613-20 - PubMed
  60. Arterioscler Thromb Vasc Biol. 2005 Jun;25(6):1102-11 - PubMed
  61. Ann N Y Acad Sci. 2006 Oct;1080:76-84 - PubMed
  62. J Biol Chem. 2003 May 2;278(18):16304-9 - PubMed
  63. Cardiovasc Res. 2002 Aug 1;55(2):329-40 - PubMed
  64. Curr Drug Targets. 2008 Oct;9(10):863-8 - PubMed
  65. Cardiovasc Res. 2011 Dec 1;92(3):449-55 - PubMed
  66. Lancet. 1994 Apr 2;343(8901):831-6 - PubMed
  67. Free Radic Biol Med. 2009 Jul 1;47(1):79-83 - PubMed
  68. J Neurosci Res. 1993 Nov 1;36(4):432-40 - PubMed
  69. Eur Heart J. 2008 Oct;29(19):2327-35 - PubMed
  70. Circ Res. 2007 Aug 3;101(3):313-21 - PubMed
  71. Trends Immunol. 2011 Aug;32(8):350-7 - PubMed
  72. Clin Sci (Lond). 2011 Mar;120(6):231-8 - PubMed
  73. Circ Res. 2003 May 2;92(8):827-39 - PubMed
  74. J Clin Invest. 2009 Jun;119(6):1583-94 - PubMed
  75. Biochim Biophys Acta. 2013 Apr;1833(4):945-53 - PubMed
  76. Med Clin North Am. 2015 Jul;99(4):711-31 - PubMed
  77. Histol Histopathol. 2004 Apr;19(2):517-25 - PubMed
  78. J Pathol. 2003 Jul;200(4):423-8 - PubMed
  79. Cell Tissue Res. 2006 Jun;324(3):475-88 - PubMed
  80. Cancer Cell. 2003 Jun;3(6):589-601 - PubMed
  81. Microbes Infect. 2003 Nov;5(14):1317-27 - PubMed
  82. Circulation. 1991 Nov;84(5):2123-34 - PubMed
  83. J Biol Chem. 1983 Dec 10;258(23):14162-5 - PubMed
  84. Am J Pathol. 2004 Feb;164(2):665-77 - PubMed
  85. J Card Fail. 2004 Aug;10 (4):328-33 - PubMed
  86. Cardiovasc Res. 2014 May 1;102(2):240-8 - PubMed
  87. Am J Pathol. 1990 Oct;137(4):801-10 - PubMed
  88. Infect Immun. 2000 Dec;68(12):6519-25 - PubMed
  89. J Biol Chem. 1997 Mar 21;272(12):7608-16 - PubMed
  90. J Clin Invest. 1995 Jan;95(1):89-103 - PubMed
  91. Clinics (Sao Paulo). 2013 Jan;68(1):75-80 - PubMed
  92. J Exp Med. 2008 Feb 18;205(2):295-303 - PubMed
  93. J Clin Invest. 2005 Mar;115(3):599-609 - PubMed
  94. Circulation. 2002 May 28;105(21):2556-61 - PubMed
  95. Biochem Biophys Res Commun. 2010 Jan 1;391(1):73-7 - PubMed
  96. J Heart Lung Transplant. 2006 Dec;25(12 ):1413-9 - PubMed
  97. Clin Biochem Rev. 2012 Feb;33(1):3-11 - PubMed
  98. Circulation. 1999 Aug 31;100(9):999-1008 - PubMed
  99. Eur Heart J. 2011 Dec;32(23):2999-3054 - PubMed
  100. Cardiovasc Pathol. 2003 Jul-Aug;12(4):186-94 - PubMed
  101. Blood. 2002 Mar 1;99(5):1785-93 - PubMed
  102. Circulation. 1997 Jun 3;95(11):2552-8 - PubMed
  103. Immunity. 2014 Jan 16;40(1):91-104 - PubMed
  104. Basic Res Cardiol. 2009 Jan;104(1):78-89 - PubMed
  105. Congest Heart Fail. 2012 Sep-Oct;18(5):284-90 - PubMed
  106. Circ Res. 2001 May 25;88(10):1080-7 - PubMed
  107. J Am Coll Cardiol. 2011 Sep 20;58(13):1332-9 - PubMed
  108. N Engl J Med. 1994 Nov 10;331(19):1286-92 - PubMed
  109. Acta Cardiol. 2009 Jun;64(3):329-34 - PubMed
  110. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1883-91 - PubMed
  111. Eur Heart J. 2010 Mar;31(6):659-66 - PubMed
  112. Biochem Biophys Res Commun. 1995 Dec 5;217(1):326-32 - PubMed
  113. Cardiovasc Res. 2004 Oct 1;64(1):24-31 - PubMed
  114. J Biol Chem. 1995 Jul 14;270(28):16518-21 - PubMed
  115. Annu Rev Immunol. 2012;30:459-89 - PubMed
  116. Biochemistry. 1995 Sep 12;34(36):11453-9 - PubMed
  117. J Biol Chem. 1996 Nov 29;271(48):30375-80 - PubMed
  118. Clin Chem. 2005 Aug;51(8):1397-404 - PubMed
  119. Am J Physiol. 1996 Sep;271(3 Pt 2):H823-33 - PubMed
  120. Clin Chem. 2006 Jan;52(1):112-9 - PubMed
  121. Int J Cardiol. 2013 Jul 31;167(2):531-6 - PubMed
  122. Annu Rev Physiol. 2010;72:19-44 - PubMed
  123. Microsc Microanal. 2012 Feb;18(1):35-49 - PubMed
  124. Circ Res. 2015 Jun 5;116(12):1907-18 - PubMed
  125. Am J Pathol. 2008 Jul;173(1):144-53 - PubMed
  126. J Cell Biol. 1989 Dec;109(6 Pt 1):2771-82 - PubMed
  127. Circulation. 2008 Mar 11;117(10):1269-76 - PubMed
  128. Eur Heart J. 2010 Nov;31(22):2765-73 - PubMed
  129. J Mol Cell Cardiol. 1995 Jun;27(6):1281-92 - PubMed
  130. Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):59-69 - PubMed
  131. Cardiovasc Res. 1990 Sep;24(9):748-53 - PubMed
  132. Biochem J. 1997 Nov 1;327 ( Pt 3):917-23 - PubMed
  133. J Mol Cell Cardiol. 1998 Sep;30(9):1749-56 - PubMed
  134. Can J Cardiol. 1996 Feb;12(2):165-71 - PubMed
  135. Anal Chem. 2012 Jul 17;84(14):6070-8 - PubMed
  136. J Biol Chem. 1997 Apr 4;272(14):9237-43 - PubMed
  137. Circulation. 2005 Jun 7;111(22):2935-42 - PubMed
  138. Clin Exp Immunol. 2005 Dec;142(3):481-9 - PubMed
  139. Curr Cardiol Rev. 2012 May;8(2):109-15 - PubMed
  140. Curr Heart Fail Rep. 2014 Sep;11(3):246-59 - PubMed
  141. Circ Res. 2000 Jun 23;86(12):1259-65 - PubMed
  142. Nat Med. 1999 Oct;5(10):1135-42 - PubMed
  143. Annu Rev Pharmacol Toxicol. 2005;45:657-87 - PubMed
  144. Clin Chem. 2003 Jun;49(6 Pt 1):958-60 - PubMed
  145. J Am Coll Cardiol. 2004 Apr 21;43(8):1383-7 - PubMed
  146. Circ Res. 1988 Mar;62(3):572-84 - PubMed
  147. Eur J Biochem. 1997 Dec 15;250(3):751-7 - PubMed
  148. J Immunol. 1993 Feb 15;150(4):1535-43 - PubMed
  149. J Biol Chem. 1999 Aug 27;274(35):24881-7 - PubMed
  150. Coron Artery Dis. 1997 Mar-Apr;8(3-4):155-61 - PubMed
  151. J Clin Invest. 1988 Dec;82(6):1963-73 - PubMed
  152. Life Sci. 2004 Feb 6;74(12):1561-72 - PubMed
  153. Clin Chim Acta. 1998 Apr 6;272(1):87-92 - PubMed
  154. Semin Hematol. 1993 Oct;30(4 Suppl 4):45-53; discussion 54-5 - PubMed
  155. J Leukoc Biol. 2007 Sep;82(3):657-65 - PubMed
  156. Circulation. 2011 Aug 9;124(6):720-30 - PubMed
  157. Cardiovasc Res. 2008 May 1;78(2):242-9 - PubMed
  158. J Am Coll Cardiol. 2006 Jun 6;47(11):2319-25 - PubMed
  159. J Mol Cell Cardiol. 2011 Oct;51(4):600-6 - PubMed
  160. Circulation. 2000 Oct 17;102(16):1944-9 - PubMed
  161. Atherosclerosis. 2006 Oct;188(2):292-300 - PubMed
  162. Blood. 1992 Jul 1;80(1):235-40 - PubMed
  163. J Biol Chem. 2001 Mar 30;276(13):10134-44 - PubMed
  164. Circ Res. 2002 Mar 22;90(5):520-30 - PubMed
  165. Circulation. 2011 Jan 25;123(3):282-91 - PubMed
  166. Matrix Biol. 2005 Jun;24(4):313-24 - PubMed
  167. Biosens Bioelectron. 2013 May 15;43:400-11 - PubMed
  168. Circulation. 2003 Jun 10;107(22):2857-63 - PubMed
  169. J Biol Chem. 1997 Jan 24;272(4):2446-51 - PubMed
  170. J Biol Chem. 1995 May 12;270(19):11025-8 - PubMed
  171. Proc Natl Acad Sci U S A. 1990 Sep;87(17):6624-8 - PubMed
  172. Br J Pharmacol. 2007 Sep;152(2):189-205 - PubMed
  173. J Immunol. 1998 Dec 15;161(12):6845-52 - PubMed
  174. Circ Res. 2012 Jan 6;110(1):159-73 - PubMed
  175. J Leukoc Biol. 1999 Feb;65(2):137-50 - PubMed
  176. Leukemia. 1998 Nov;12(11):1789-95 - PubMed
  177. Circ Res. 2013 Feb 15;112(4):675-88 - PubMed
  178. J Clin Invest. 1993 Nov;92(5):2303-12 - PubMed
  179. Histochem Cell Biol. 1999 Jul;112(1):1-23 - PubMed
  180. Circ Res. 2011 May 27;108(11):1328-39 - PubMed
  181. J Biol Chem. 1995 Oct 6;270(40):23688-92 - PubMed
  182. Pathol Res Pract. 2000;196(1):23-33 - PubMed
  183. Clin Interv Aging. 2014 Jul 11;9:1081-90 - PubMed
  184. J Dent Res. 2010 Dec;89(12):1439-43 - PubMed
  185. Nat Med. 2007 Jul;13(7):851-6 - PubMed
  186. J Proteome Res. 2010 May 7;9(5):2649-57 - PubMed
  187. J Mol Cell Cardiol. 2012 Apr;52(4):873-82 - PubMed
  188. J Pathol. 1996 Jul;179(3):321-5 - PubMed
  189. Biochem Biophys Res Commun. 2004 Jul 30;320(3):907-13 - PubMed
  190. J Leukoc Biol. 2001 Jan;69(1):57-62 - PubMed
  191. Immunity. 2010 Nov 24;33(5):657-70 - PubMed
  192. Physiol Rev. 2012 Apr;92(2):635-88 - PubMed
  193. Biochem J. 1997 Mar 15;322 ( Pt 3):809-14 - PubMed
  194. Basic Res Cardiol. 1995 Sep-Oct;90(5):357-64 - PubMed
  195. J Biol Chem. 2011 May 13;286(19):17365-75 - PubMed
  196. BMC Genomics. 2009 Feb 05;10:65 - PubMed
  197. J Immunol. 1995 Apr 15;154(8):4157-65 - PubMed
  198. FEBS Lett. 1995 Aug 7;369(2-3):249-51 - PubMed
  199. J Transl Med. 2015 Apr 24;13:129 - PubMed
  200. Arterioscler Thromb Vasc Biol. 2006 Apr;26(4):716-28 - PubMed
  201. Circulation. 2008 Nov 11;118(20):2057-62 - PubMed
  202. Basic Res Cardiol. 2010 Nov;105(6):687-701 - PubMed
  203. J Exp Med. 2007 Nov 26;204(12):3037-47 - PubMed
  204. Pharmacol Ther. 2009 Aug;123(2):255-78 - PubMed
  205. J Leukoc Biol. 1996 Oct;60(4):540-5 - PubMed
  206. Eur Heart J. 2008 Dec;29(23):2843-50 - PubMed
  207. Nat Rev Immunol. 2010 Jun;10(6):427-39 - PubMed
  208. Lab Invest. 2001 Jul;81(7):1015-24 - PubMed
  209. Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2726-31 - PubMed
  210. Circ J. 2010 Jan;74(1):109-19 - PubMed
  211. J Exp Med. 2009 Jan 16;206(1):113-23 - PubMed
  212. J Mol Cell Cardiol. 2010 Mar;48(3):504-11 - PubMed
  213. J Am Coll Cardiol. 2006 Feb 7;47(3):626-34 - PubMed
  214. Nature. 2011 May 19;473(7347):298-307 - PubMed
  215. Vascul Pharmacol. 2013 Mar;58(3):182-8 - PubMed
  216. J Clin Invest. 2005 Aug;115(8):2108-18 - PubMed
  217. J Mol Cell Cardiol. 2010 Mar;48(3):530-7 - PubMed
  218. Cardiovasc Res. 2002 Jan;53(1):31-47 - PubMed
  219. J Cardiovasc Transl Res. 2011 Feb;4(1):73-81 - PubMed
  220. Resuscitation. 2012 Jun;83(6):684-91 - PubMed
  221. Blood. 1997 May 15;89(10):3503-21 - PubMed
  222. Am J Med. 2003 Aug 15;115(3):185-90 - PubMed
  223. Biochem J. 1993 Oct 15;295 ( Pt 2):595-8 - PubMed
  224. Circ Res. 2004 Jun 25;94(12):1543-53 - PubMed
  225. Am Heart J. 2015 May;169(5):674-83 - PubMed
  226. J Biol Chem. 1985 Oct 5;260(22):12367-76 - PubMed
  227. Coron Artery Dis. 2011 Aug;22(5):333-8 - PubMed
  228. J Mol Cell Cardiol. 1995 Oct;27(10):2177-89 - PubMed
  229. J Am Coll Cardiol. 2010 Jun 8;55(23):2590-8 - PubMed
  230. Circ Res. 1991 Jul;69(1):76-85 - PubMed
  231. J Cell Mol Med. 2009 Sep;13(9B):3485-96 - PubMed
  232. Circulation. 1993 Jul;88(1):82-91 - PubMed
  233. Eur J Heart Fail. 2004 Mar 15;6(3):319-25 - PubMed
  234. Birth Defects Res A Clin Mol Teratol. 2011 Jun;91(6):535-50 - PubMed
  235. Nat Rev Cardiol. 2010 Jan;7(1):30-7 - PubMed
  236. Circ Cardiovasc Qual Outcomes. 2010 Sep;3(5):459-67 - PubMed
  237. Circulation. 2003 Sep 16;108(11):1395-403 - PubMed
  238. J Cell Sci Ther. 2011 Dec 1;2012(S5):null - PubMed
  239. Circ Res. 2011 Mar 4;108(5):582-92 - PubMed
  240. J Am Coll Cardiol. 2009 Jun 30;54(1):60-8 - PubMed
  241. Cardiovasc Pathol. 2005 Jan-Feb;14(1):1-11 - PubMed
  242. Circulation. 1998 Jul 14;98 (2):149-56 - PubMed
  243. Circulation. 2003 Sep 23;108(12):1440-5 - PubMed
  244. Cell. 2011 Sep 16;146(6):873-87 - PubMed
  245. N Engl J Med. 2009 Dec 24;361(26):2538-47 - PubMed
  246. Nat Med. 2003 Jun;9(6):677-84 - PubMed
  247. J Biol Chem. 2001 Oct 5;276(40):37258-65 - PubMed
  248. Circulation. 1998 Jan 27;97(3):282-9 - PubMed
  249. Circulation. 2003 Apr 1;107(12):1579-85 - PubMed
  250. Br Heart J. 1994 Feb;71(2):135-40 - PubMed
  251. J Biol Chem. 1996 Jun 21;271(25):14657-60 - PubMed
  252. Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2216-28 - PubMed
  253. Lab Invest. 1996 Jan;74(1):86-107 - PubMed
  254. Jpn Circ J. 1996 Feb;60(2):108-14 - PubMed
  255. Brain Behav Immun. 2014 May;38:59-65 - PubMed
  256. N Engl J Med. 2003 Oct 23;349(17):1595-604 - PubMed
  257. J Cell Commun Signal. 2009 Dec;3(3-4):163-5 - PubMed
  258. N Engl J Med. 2009 Aug 27;361(9):858-67 - PubMed
  259. Int J Biochem Cell Biol. 2011 Oct;43(10):1450-8 - PubMed
  260. Curr Drug Targets Inflamm Allergy. 2003 Sep;2(3):242-56 - PubMed
  261. Blood. 1994 Oct 1;84(7):2068-101 - PubMed
  262. Blood. 1999 Oct 1;94(7):2487-96 - PubMed
  263. Circulation. 2007 Feb 27;115(8):962-71 - PubMed
  264. PLoS One. 2012;7(5):e36814 - PubMed
  265. Atherosclerosis. 2008 Mar;197(1):95-104 - PubMed
  266. QJM. 2004 Apr;97(4):187-98 - PubMed
  267. N Engl J Med. 2002 Jul 4;347(1):5-12 - PubMed
  268. Clin Chem Lab Med. 2015 Apr;53(5):635-52 - PubMed
  269. J Immunol. 2009 Mar 15;182(6):3866-76 - PubMed
  270. Exp Biol Med (Maywood). 2005 Oct;230(9):621-30 - PubMed
  271. Dev Dyn. 2007 Oct;236(10):2852-64 - PubMed
  272. J Am Coll Cardiol. 1993 Dec;22(7):2001-6 - PubMed
  273. Circulation. 2007 Mar 27;115(12 ):1563-70 - PubMed

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