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Magn Reson Imaging Clin N Am. 2015 Nov;23(4):643-55. doi: 10.1016/j.mric.2015.05.012. Epub 2015 Jul 09.

Magnetic Resonance-Guided Drug Delivery.

Magnetic resonance imaging clinics of North America

Andrew S Mikhail, Ari Partanen, Pavel Yarmolenko, Aradhana M Venkatesan, Bradford J Wood

Affiliations

  1. Center for Interventional Oncology, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
  2. Center for Interventional Oncology, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA; Philips Healthcare, 3000 Minuteman Road, Andover, MA 01810, USA.
  3. The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National Medical Center, 111 Michigan Avenue, Washington, DC 20010, USA.
  4. Section of Abdominal Imaging, Department of Diagnostic Radiology, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030-4009, USA.
  5. Center for Interventional Oncology, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Electronic address: [email protected].

PMID: 26499281 PMCID: PMC5580964 DOI: 10.1016/j.mric.2015.05.012

Abstract

The use of clinical imaging modalities for the guidance of targeted drug delivery systems, known as image-guided drug delivery (IGDD), has emerged as a promising strategy for enhancing antitumor efficacy. MR imaging is particularly well suited for IGDD applications because of its ability to acquire images and quantitative measurements with high spatiotemporal resolution. The goal of IGDD strategies is to improve treatment outcomes by facilitating planning, real-time guidance, and personalization of pharmacologic interventions. This article reviews basic principles of targeted drug delivery and highlights the current status, emerging applications, and future paradigms of MR-guided drug delivery.

Copyright © 2015 Elsevier Inc. All rights reserved.

Keywords: Cancer; Drug delivery; High-intensity focused ultrasound; Imaging guidance; MR imaging; Nanomedicine; Thermosensitive liposome; Tumor targeting

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