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Yu N, He C, Awuti G, et al. Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method. J Anal Methods Chem. 2015;2015:974039doi: 10.1155/2015/974039.
Yu, N., He, C., Awuti, G., Zeng, C., Xing, J., & Huang, W. (2015). Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method. Journal of analytical methods in chemistry, 2015974039. https://doi.org/10.1155/2015/974039
Yu, Ning, et al. "Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method." Journal of analytical methods in chemistry vol. 2015 (2015): 974039. doi: https://doi.org/10.1155/2015/974039
Yu N, He C, Awuti G, Zeng C, Xing J, Huang W. Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method. J Anal Methods Chem. 2015;2015:974039. doi: 10.1155/2015/974039. Epub 2015 Oct 26. PMID: 26587308; PMCID: PMC4637494.
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J Anal Methods Chem. 2015;2015:974039. doi: 10.1155/2015/974039. Epub 2015 Oct 26.

Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method.

Journal of analytical methods in chemistry

Ning Yu, ChenHui He, Gulistan Awuti, Cheng Zeng, JianGuo Xing, Wei Huang

Affiliations

  1. College of Pharmacy, Shihezi University, Shihezi 832002, China ; Xinjiang Institute of Metaria Medica, Urumqi 830004, China.
  2. Xinjiang Institute of Metaria Medica, Urumqi 830004, China.
  3. Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830005, China.
  4. Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100052, China.

PMID: 26587308 PMCID: PMC4637494 DOI: 10.1155/2015/974039

Abstract

In this study, a sensitive, precise, and accurate HPLC-UV method was developed and validated to simultaneously determine the six analytes (luteolin-7-O-β-D-glucuronide, apigenin-7-O-β-D-glucuronide, diosmetin-7-O-β-D-glucuronide, acacetin-7-O-β-D-glucuronide, tilianin, and rosmarinic acid) in Yixin Badiranjibuya Granules, in which five analytes (i.e., luteolin-7-O-β-D-glucuronide, apigenin-7-O-β-D-glucuronide, diosmetin-7-O-β-D-glucuronide, acacetin-7-O-β-D-glucuronide, and rosmarinic acid) were determined for the first time in Yixin Badiranjibuya Granules, the content of tilianin in Yixin Badiranjibuya Granules was reported in other literatures, and the content of tilianin in our work was higher than that of the literature reports. The quality of 11 batch samples from four different manufacturers was evaluated using the proposed determination method. The contents of the six analytes were largely different among samples from various manufacturers. Therefore, this determination method can provide a scientific basis for quality evaluation and control of Yixin Badiranjibuya Granules.

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