Display options
Cite
Alfaro C, Echeveste JI, Rodriguez-Ruiz ME, et al. Functional expression of CD137 (4-1BB) on T helper follicular cells. Oncoimmunology. 2015;4(12):e1054597doi: 10.1080/2162402X.2015.1054597.
Alfaro, C., Echeveste, J. I., Rodriguez-Ruiz, M. E., Solorzano, J. L., Perez-Gracia, J. L., Idoate, M. A., Lopez-Picazo, J. M., Sanchez-Paulete, A. R., Labiano, S., Rouzaut, A., Oñate, C., Aznar, A., Lozano, M. D., & Melero, I. (2015). Functional expression of CD137 (4-1BB) on T helper follicular cells. Oncoimmunology, 4(12), e1054597. https://doi.org/10.1080/2162402X.2015.1054597
Alfaro, Carlos, et al. "Functional expression of CD137 (4-1BB) on T helper follicular cells." Oncoimmunology vol. 4,12 (2015): e1054597. doi: https://doi.org/10.1080/2162402X.2015.1054597
Alfaro C, Echeveste JI, Rodriguez-Ruiz ME, Solorzano JL, Perez-Gracia JL, Idoate MA, Lopez-Picazo JM, Sanchez-Paulete AR, Labiano S, Rouzaut A, Oñate C, Aznar A, Lozano MD, Melero I. Functional expression of CD137 (4-1BB) on T helper follicular cells. Oncoimmunology. 2015 May 29;4(12):e1054597. doi: 10.1080/2162402X.2015.1054597. eCollection 2015 Dec. PMID: 26587331; PMCID: PMC4635945.
Copy Download .nbib Format: NLM
Share it on

Oncoimmunology. 2015 May 29;4(12):e1054597. doi: 10.1080/2162402X.2015.1054597. eCollection 2015 Dec.

Functional expression of CD137 (4-1BB) on T helper follicular cells.

Oncoimmunology

Carlos Alfaro, Jose I Echeveste, Maria E Rodriguez-Ruiz, Jose L Solorzano, Jose L Perez-Gracia, Miguel A Idoate, Jose M Lopez-Picazo, Alfonso R Sanchez-Paulete, Sara Labiano, Ana Rouzaut, Carmen Oñate, Angela Aznar, Maria D Lozano, Ignacio Melero

Affiliations

  1. Division of Gene Therapy and Hepatology; Centre for Applied Medical Research ; Pamplona, Spain ; Oncology Department; University Clinic of Navarra ; Pamplona, Spain.
  2. Pathology Department; University Clinic of Navarra ; Pamplona, Spain.
  3. Oncology Department; University Clinic of Navarra ; Pamplona, Spain.
  4. Division of Gene Therapy and Hepatology; Centre for Applied Medical Research ; Pamplona, Spain.

PMID: 26587331 PMCID: PMC4635945 DOI: 10.1080/2162402X.2015.1054597

Abstract

CD137 (4-1BB) is a surface protein initially discovered to mark activated T lymphocytes. However, its broader expression pattern also encompasses activated NK cells, B cells and myeloid cells, including mature dendritic cells. In this study, we have immunostained for CD137 on paraffin-embedded lymphoid tissues including tonsils, lymph nodes, ectopic tertiary lymphoid tissue in Hashimoto thyroiditis and cancer. Surprisingly, immunostaining mainly decorated intrafollicular lymphocytes in the tissues analyzed, with only scattered staining in interfollicular areas. Moreover, pathologic lymphoid follicles in follicular lymphoma and tertiary lymphoid tissue associated with non-small cell lung cancer showed a similar pattern of immunostaining. Multispectral fluorescence cytometry demonstrated that CD137 expression was restricted to CD4

Keywords: CD137 (4-1BB)v; T helper follicular cells; lymphoid follicle; tertiary lymphoid tissue

References

  1. Immunol Rev. 2009 May;229(1):192-215 - PubMed
  2. Blood. 2005 Dec 15;106(13):4241-8 - PubMed
  3. Nat Rev Immunol. 2013 Jun;13(6):412-26 - PubMed
  4. J Immunol. 2013 Jun 15;190(12):6694-706 - PubMed
  5. Eur J Immunol. 1994 Sep;24(9):2219-27 - PubMed
  6. Immunity. 2014 Oct 16;41(4):529-42 - PubMed
  7. Nat Med. 1997 Jun;3(6):682-5 - PubMed
  8. Proc Natl Acad Sci U S A. 2012 Jan 3;109(1):E13-22 - PubMed
  9. Blood. 2011 Aug 4;118(5):1350-8 - PubMed
  10. Nat Med. 2002 Dec;8(12):1405-13 - PubMed
  11. Cell Immunol. 1998 Dec 15;190(2):167-72 - PubMed
  12. J Immunol. 2010 Jan 15;184(2):787-95 - PubMed
  13. Nat Med. 2004 Oct;10(10):1088-94 - PubMed
  14. J Clin Invest. 2006 Oct;116(10):2622-32 - PubMed
  15. Trends Pharmacol Sci. 2008 Aug;29(8):383-90 - PubMed
  16. Cancer Discov. 2012 Jul;2(7):608-23 - PubMed
  17. Blood. 2010 Sep 9;116(10):1726-33 - PubMed
  18. Immunity. 2013 Sep 19;39(3):417-20 - PubMed
  19. Cancer Res. 2011 Feb 1;71(3):801-11 - PubMed
  20. Nat Immunol. 2008 Aug;9(8):917-26 - PubMed
  21. J Exp Med. 1997 Jul 7;186(1):47-55 - PubMed
  22. Am J Clin Pathol. 2001 Apr;115(4):543-9 - PubMed
  23. Clin Cancer Res. 2013 Mar 1;19(5):1044-53 - PubMed
  24. Semin Oncol. 2010 Oct;37(5):508-16 - PubMed
  25. Mol Ther. 2012 Sep;20(9):1664-75 - PubMed
  26. J Immunol. 2002 May 1;168(9):4262-7 - PubMed
  27. Nat Rev Immunol. 2014 May;14(5):284-5 - PubMed
  28. Front Immunol. 2015 Feb 02;6:16 - PubMed
  29. J Biol Chem. 1997 May 30;272(22):14272-6 - PubMed
  30. J Immunol. 2005 Jul 15;175(2):884-90 - PubMed

Publication Types