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Gastroenterol Rep (Oxf). 2018 Feb 01;6(1):65-67. doi: 10.1093/gastro/gov056. Epub 2015 Nov 03.

Vogt-Koyanagi-Harada syndrome and Crohn's disease: an exceptional association.

Gastroenterology report

Ahlem Souguir, Aya Hammami, Wafa Dahmeni, Hanene Jaziri, Imed Ben Mansour, Ahlem Zayene, Aida Ben Slama, Mehdi Ksiaa, Ahlem Brahem, Salem Ajmi, Ali Jmaa

Affiliations

  1. Department of Gastroenterology, University Hospital Sahloul, Sousse, Tunisia [email protected].
  2. Department of Gastroenterology, University Hospital Sahloul, Sousse, Tunisia.

PMID: 26534928 PMCID: PMC5806415 DOI: 10.1093/gastro/gov056

Abstract

Vogt-Koyanagi-Harada disease (VKH) is a rare, multisystem disease of melanocyte-containing organs. It is characterized by diffuse, granulomatous inflammation involving various organs. It has been reported to occur in association with other autoimmune disorders. We report the case of a female patient who was diagnosed with VKH at the age of 4 years and who was treated with corticosteroids until the age of 16. Twenty years later, Crohn's disease was diagnosed, with a severe flare-up. Three cases of VKH associated with ulcerative colitis have previously been reported anecdotally but, to our knowledge, this is the first case occurring in association to Crohn's disease.

© The Author(s) 2015. Published by Oxford University Press and the Digestive Science Publishing Co. Limited.

Keywords: Crohn’s disease; Vogt-Koyanagi-Harada disease; granulomatous inflammation

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