Display options
Cite
Jentzen W, Richter M, Nagarajah J, et al. Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy (124)I PET/CT imaging. EJNMMI Phys. 2014;1(1):100doi: 10.1186/s40658-014-0100-1.
Jentzen, W., Richter, M., Nagarajah, J., Poeppel, T. D., Brandau, W., Dawes, C., Bockisch, A., & Binse, I. (2014). Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy (124)I PET/CT imaging. EJNMMI physics, 1(1), 100. https://doi.org/10.1186/s40658-014-0100-1
Jentzen, Walter, et al. "Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy (124)I PET/CT imaging." EJNMMI physics vol. 1,1 (2014): 100. doi: https://doi.org/10.1186/s40658-014-0100-1
Jentzen W, Richter M, Nagarajah J, Poeppel TD, Brandau W, Dawes C, Bockisch A, Binse I. Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy (124)I PET/CT imaging. EJNMMI Phys. 2014 Dec;1(1):100. doi: 10.1186/s40658-014-0100-1. Epub 2014 Dec 06. PMID: 26501458; PMCID: PMC4545453.
Copy Download .nbib Format: NLM
Share it on

EJNMMI Phys. 2014 Dec;1(1):100. doi: 10.1186/s40658-014-0100-1. Epub 2014 Dec 06.

Chewing-gum stimulation did not reduce the absorbed dose to salivary glands during radioiodine treatment of thyroid cancer as inferred from pre-therapy (124)I PET/CT imaging.

EJNMMI physics

Walter Jentzen, Marion Richter, James Nagarajah, Thorsten Dirk Poeppel, Wolfgang Brandau, Colin Dawes, Andreas Bockisch, Ina Binse

Affiliations

  1. Klinik für Nuklearmedizin, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany. [email protected].
  2. Klinik für Nuklearmedizin, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany. [email protected].
  3. Klinik für Nuklearmedizin, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany. [email protected].
  4. Klinik für Nuklearmedizin, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany. [email protected].
  5. Klinik für Nuklearmedizin, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany. [email protected].
  6. Department of Oral Biology, Faculty of Dentistry, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, Manitoba,, R3E 0W2, Canada. [email protected].
  7. Klinik für Nuklearmedizin, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany. [email protected].
  8. Klinik für Nuklearmedizin, Universität Duisburg-Essen, Hufelandstrasse 55, D-45122, Essen, Germany. [email protected].

PMID: 26501458 PMCID: PMC4545453 DOI: 10.1186/s40658-014-0100-1

Abstract

BACKGROUND: The goal of this prospective study was to estimate the absorbed (radiation) doses to salivary glands in radioiodine therapy of thyroid cancer under chewing-gum stimulation using (124)I positron emission tomography (PET)/computed tomography (CT) imaging.

METHODS: Duplex ultrasonography was conducted in three test persons for visual comparison of the glandular blood flow with three different stimulation types (no stimulation, chewing tasteless gum base, sucking on lemon slices). Ten patients with newly diagnosed differentiated thyroid cancer received (124)I PET/CT dosimetry after thyroidectomy and prior to radioiodine therapy. Patients underwent a series of three (124)I PET/CT scans (4, 24, and ≥96 h after administration of 23 MBq (124)I). They were instructed to chew gum base (tasteless) approximately 20 min after ingesting the (124)I-containing capsule in the course of the first day. Absorbed doses per administered (131)I activity to the salivary glands were calculated and compared with the previously published results of the lemon-juice stimulation and non-stimulation groups.

RESULTS: The sonograms in the three test persons showed that glandular blood perfusion by lemon-juice stimulation was clearly increased compared with non-stimulation or chewing of gum base. The sonogram comparison between the chewing-gum stimulation and non-stimulation demonstrated a minor increase of blood flow for the gum base-stimulated salivary glands. The mean ± standard deviation of the absorbed dose per activity under chewing-gum stimulation for the submandibular and parotid glands (within parentheses) was 0.22 ± 0.09 Gy/GBq (0.22 ± 0.08 Gy/GBq). Compared with the absorbed doses of the non-stimulation group, 0.24 ± 0.08 Gy/GBq (0.21 ± 0.05 Gy/GBq), those of the chewing-gum stimulation group showed no significant change (P > 0.60), but the absorbed doses of the lemon-juice stimulation group, 0.35 ± 0.14 Gy/GBq (0.33 ± 0.09 Gy/GBq), were significantly higher (P < 0.04) than those of the chewing-gum stimulation group.

CONCLUSIONS: The results suggest that salivary flow induced by chewing gum base does not cause a significant reduction of the salivary gland absorbed dose compared with that in the non-stimulation group. The increased blood flow appears to be a decisive factor causing the increased (131)I absorbed doses in the lemon-juice stimulation group.

Keywords: Dosimetry; Iodine-124; Radioiodine therapy; Salivary gland; Thyroid carcinoma

References

  1. Nuklearmedizin. 2007;46(4):121-8 - PubMed
  2. Eur J Nucl Med Mol Imaging. 2008 Oct;35(10):1941-59 - PubMed
  3. Caries Res. 1992;26(3):176-82 - PubMed
  4. Thyroid. 2009 Sep;19(9):1005-8 - PubMed
  5. Arch Oral Biol. 1995 Jul;40(7):585-8 - PubMed
  6. Thyroid. 2013 Aug;23(8):1029-36 - PubMed
  7. Q J Nucl Med Mol Imaging. 2013 Mar;57(1):79-91 - PubMed
  8. J Nucl Med. 2005 Feb;46(2):261-6 - PubMed
  9. J Natl Compr Canc Netw. 2010 Nov;8(11):1277-86; quiz 1287 - PubMed
  10. Thyroid. 2010 Oct;20(10):1113-9 - PubMed
  11. Eur J Nucl Med Mol Imaging. 2010 Dec;37(12 ):2298-306 - PubMed
  12. Eur J Nucl Med Mol Imaging. 2010 May;37(5):884-95 - PubMed
  13. Clin Oncol (R Coll Radiol). 2007 Feb;19(1):83-6 - PubMed
  14. Future Oncol. 2013 Aug;9(8):1145-59 - PubMed
  15. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Oct;86(4):476-81 - PubMed
  16. J Nucl Med. 2010 Apr;51(4):618-23 - PubMed

Publication Types