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Reichert MC, Lammert F. The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence. United European Gastroenterol J. 2015;3(5):409-18doi: 10.1177/2050640615576676.
Reichert, M. C., & Lammert, F. (2015). The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence. United European gastroenterology journal, 3(5), 409-18. https://doi.org/10.1177/2050640615576676
Reichert, Matthias C, and Lammert, Frank. "The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence." United European gastroenterology journal vol. 3,5 (2015): 409-18. doi: https://doi.org/10.1177/2050640615576676
Reichert MC, Lammert F. The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence. United European Gastroenterol J. 2015 Oct;3(5):409-18. doi: 10.1177/2050640615576676. PMID: 26535118; PMCID: PMC4625748.
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United European Gastroenterol J. 2015 Oct;3(5):409-18. doi: 10.1177/2050640615576676.

The genetic epidemiology of diverticulosis and diverticular disease: Emerging evidence.

United European gastroenterology journal

Matthias C Reichert, Frank Lammert

Affiliations

  1. Department of Medicine II, Saarland University Medical Center, Homburg, Germany.

PMID: 26535118 PMCID: PMC4625748 DOI: 10.1177/2050640615576676

Abstract

Diverticular disease (DD) is one of the most prevalent gastrointestinal disorders. The pathogenesis of diverticulosis and DD is controversially discussed. Current studies call the traditional concept of a fibre-deficient diet causing the development of diverticula into question. Data from two recent twin studies have provided conclusive evidence for a strong genetic component to diverticulosis. Although genomewide association studies have provided new insights into the polygenic architecture of human diseases, genomic research in diverticulosis and DD has just been started. This is an astonishing fact given the high morbidity and mortality of the disease, as well as the substantial economic burden on health care systems. For this review, we provide an update of the molecular pathobiology and summarise recent evidence supporting the hypothesis that distinct, yet unidentified genetic variants contribute to the development of diverticulosis and DD.

Keywords: Diverticular disease; diverticulosis; genetics; genomewide association studies; personalised medicine; polygenic disease; polymorphism; risk prediction

References

  1. Aliment Pharmacol Ther. 2004 Apr 1;19(7):765-9 - PubMed
  2. Dig Dis Sci. 1985 Feb;30(2):182-3 - PubMed
  3. Gut. 1985 Jun;26(6):544-9 - PubMed
  4. Gut. 2014 Sep;63(9):1450-6 - PubMed
  5. Tohoku J Exp Med. 1993 Oct;171(2):145-51 - PubMed
  6. World J Gastroenterol. 2008 Apr 21;14(15):2411-3 - PubMed
  7. Colorectal Dis. 2011 Mar;13(3):312-6 - PubMed
  8. Ann Surg. 2014 Jun;259(6):1132-7 - PubMed
  9. Dis Colon Rectum. 2008 Apr;51(4):450-5 - PubMed
  10. Dis Colon Rectum. 1981 Jul-Aug;24(5):385-7 - PubMed
  11. BMJ. 2011 Jul 19;343 :d4131 - PubMed
  12. Colorectal Dis. 2013 May;15(5):e266-70 - PubMed
  13. Clin Gastroenterol Hepatol. 2013 Dec;11(12):1631-5 - PubMed
  14. Gastroenterology. 2011 May;140(5):1427-33 - PubMed
  15. Br J Surg. 2015 Jan;102(1):119-24 - PubMed
  16. Rom J Gastroenterol. 2004 Dec;13(4):281-5 - PubMed
  17. Dis Colon Rectum. 1986 May;29(5):330-5 - PubMed
  18. Br Med J. 1979 Jun 2;1(6176):1465-6 - PubMed
  19. PLoS One. 2013 Dec 10;8(12):e81137 - PubMed
  20. Lancet. 1979 Mar 10;1(8115):511-4 - PubMed
  21. Eur J Gastroenterol Hepatol. 2005 Aug;17(8):871-5 - PubMed
  22. Int Urogynecol J Pelvic Floor Dysfunct. 2009 Sep;20(9):1113-8 - PubMed
  23. Chir Ital. 1985 Dec;37(6):656-9 - PubMed
  24. Clin Gastroenterol Hepatol. 2013 Dec;11(12):1622-7 - PubMed
  25. J Nutr. 1998 Apr;128(4):714-9 - PubMed
  26. World J Gastroenterol. 2009 Jan 28;15(4):457-61 - PubMed
  27. Virchows Arch. 2007 Jun;450(6):713-7 - PubMed
  28. Best Pract Res Clin Gastroenterol. 2002 Aug;16(4):529-42 - PubMed
  29. Gut. 1969 Dec;10(12):1004-8 - PubMed
  30. Nat Rev Gastroenterol Hepatol. 2010 Dec;7(12):669-81 - PubMed
  31. East Afr Med J. 1998 Sep;75(9):540-3 - PubMed
  32. Int J Colorectal Dis. 2008 Apr;23(4):375-81 - PubMed
  33. Aliment Pharmacol Ther. 2012 May;35(9):1103-7 - PubMed
  34. Int J Colorectal Dis. 2001 Aug;16(4):257-61 - PubMed
  35. Am J Med Genet Suppl. 1987;3:303-9 - PubMed
  36. Gastroenterology. 2013 Apr;144(4):736-742.e1; quiz e14 - PubMed
  37. Dis Colon Rectum. 2000 Oct;43(10):1412-8 - PubMed
  38. Afr J Med Med Sci. 1989 Dec;18(4):241-4 - PubMed
  39. Am Surg. 2000 Feb;66(2):200-3 - PubMed
  40. Science. 2009 Jan 2;323(5910):133-8 - PubMed
  41. Br Med J. 1971 May 22;2(5759):450-4 - PubMed
  42. Liver Int. 2013 Mar;33(3):338-52 - PubMed
  43. Colorectal Dis. 2002 May;4(3):189-192 - PubMed
  44. Gastroenterology. 2009 Mar;136(3):741-54 - PubMed
  45. Gastroenterology. 2012 Feb;142(2):266-72.e1 - PubMed
  46. United European Gastroenterol J. 2013 Jun;1(3):191-7 - PubMed
  47. J R Coll Surg Edinb. 1987 Aug;32(4):255-6 - PubMed
  48. Arch Intern Med. 1984 Jan;144(1):203 - PubMed
  49. Dis Colon Rectum. 1991 Jun;34(6):498-501 - PubMed
  50. Colorectal Dis. 2005 Nov;7(6):559-62 - PubMed
  51. Scand J Surg. 2010;99(1):14-7 - PubMed
  52. World J Gastroenterol. 2013 Dec 14;19(46):8709-13 - PubMed
  53. Clin Gastroenterol Hepatol. 2013 Dec;11(12):1609-13 - PubMed
  54. Br Med J. 1967 Sep 23;3(5568):762-3 - PubMed
  55. Aliment Pharmacol Ther. 2003 Nov;18 Suppl 3:71-4 - PubMed
  56. Gastroenterology. 2009 Apr;136(4):1198-205 - PubMed
  57. Br Med J. 1976 Feb 21;1(6007):424-5 - PubMed
  58. Transplant Proc. 2007 May;39(4):1054-6 - PubMed
  59. Digestion. 2012;86(3):201-5 - PubMed
  60. Korean J Intern Med. 2010 Jun;25(2):140-6 - PubMed
  61. Clin Gastroenterol Hepatol. 2013 Dec;11(12):1614-9 - PubMed
  62. JAMA Surg. 2015 Jan;150(1):74-7 - PubMed
  63. Am J Gastroenterol. 2009 May;104(5):1221-30 - PubMed
  64. J Pediatr Surg. 2012 Sep;47(9):E33-5 - PubMed
  65. MMW Munch Med Wochenschr. 1979 Jul 13;121(28):947-8 - PubMed
  66. Am J Med Genet A. 2005 Aug 15;137(1):52-4 - PubMed
  67. JAMA. 2008 Aug 27;300(8):907-14 - PubMed
  68. Trop Geogr Med. 1988 Jan;40(1):54-7 - PubMed
  69. Gastroenterology. 2009 Jan;136(1):115-122.e1 - PubMed
  70. World J Gastrointest Endosc. 2013 Aug 16;5(8):391-7 - PubMed
  71. Am J Clin Nutr. 1994 Nov;60(5):757-64 - PubMed
  72. Am J Med Genet A. 2005 May 15;135(1):75-80 - PubMed
  73. Gastroenterology. 2012 Nov;143(5):1179-87.e1-3 - PubMed
  74. Int J Colorectal Dis. 2006 Mar;21(2):190-1 - PubMed
  75. Gut. 2009 Aug;58(8):1063-9 - PubMed
  76. Niger J Clin Pract. 2013 Apr-Jun;16(2):226-31 - PubMed
  77. Br J Surg. 2011 Jul;98(7):997-1002 - PubMed
  78. Am J Gastroenterol. 2012 Feb;107(2):296-302 - PubMed
  79. Ann Intern Med. 1980 Feb;92(2 Pt 1):202-4 - PubMed
  80. Int J Colorectal Dis. 2014 Mar;29(3):379-85 - PubMed
  81. Dig Liver Dis. 2011 Feb;43(2):98-101 - PubMed
  82. Postgrad Med J. 1998 Aug;74(874):495-7 - PubMed
  83. Arch Environ Health. 1970 Feb;20(2):266-73 - PubMed
  84. N Engl J Med. 2000 Mar 9;342(10):673-80 - PubMed
  85. Niger Postgrad Med J. 2012 Dec;19(4):219-24 - PubMed
  86. Colorectal Dis. 2014 Jun;16(6):O189-96 - PubMed

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