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Vakil N, Niklasson A, Denison H, et al. Gender differences in symptoms in partial responders to proton pump inhibitors for gastro-oesophageal reflux disease. United European Gastroenterol J. 2015;3(5):443-52doi: 10.1177/2050640614558343.
Vakil, N., Niklasson, A., Denison, H., & Rydén, A. (2015). Gender differences in symptoms in partial responders to proton pump inhibitors for gastro-oesophageal reflux disease. United European gastroenterology journal, 3(5), 443-52. https://doi.org/10.1177/2050640614558343
Vakil, N, et al. "Gender differences in symptoms in partial responders to proton pump inhibitors for gastro-oesophageal reflux disease." United European gastroenterology journal vol. 3,5 (2015): 443-52. doi: https://doi.org/10.1177/2050640614558343
Vakil N, Niklasson A, Denison H, Rydén A. Gender differences in symptoms in partial responders to proton pump inhibitors for gastro-oesophageal reflux disease. United European Gastroenterol J. 2015 Oct;3(5):443-52. doi: 10.1177/2050640614558343. PMID: 26535123; PMCID: PMC4625745.
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United European Gastroenterol J. 2015 Oct;3(5):443-52. doi: 10.1177/2050640614558343.

Gender differences in symptoms in partial responders to proton pump inhibitors for gastro-oesophageal reflux disease.

United European gastroenterology journal

N Vakil, A Niklasson, H Denison, A Rydén

Affiliations

  1. University of Wisconsin Medical School and Public Health, Madison, USA.
  2. AstraZeneca R&D, Mölndal, Sweden.

PMID: 26535123 PMCID: PMC4625745 DOI: 10.1177/2050640614558343

Abstract

BACKGROUND: Gender differences may exist in the symptom experience of patients with gastro-oesophageal reflux disease (GERD) who have a partial response to proton pump inhibitors (PPIs).

OBJECTIVE: The purpose of this study was to analyse gender differences in partial responders to PPIs.

METHODS: Patients with GERD who responded partially to PPIs (n = 580; NCT00703534) completed the Reflux Symptom Questionnaire 7-day recall (RESQ-7) and the Gastrointestinal Symptom Rating Scale (GSRS). Anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale.

RESULTS: Women had significantly higher RESQ-7 domain scores than men for Heartburn (frequency: 4.3 vs 3.9; intensity: 3.1 vs 2.8), Burping (frequency: 4.9 vs 4.4; intensity: 3.1 vs 2.8) and Hoarseness, cough and difficulty swallowing (frequency: 2.6 vs 2.2; intensity: 1.8 vs 1.5), and had higher GSRS domain discomfort scores than men for Abdominal pain (3.51 vs 3.23), Indigestion (3.80 vs 3.45) and Constipation (2.69 vs 2.17) (all p < 0.05). Anxiety and depression were significantly more prevalent in women than in men.

CONCLUSION: In this population of partial responders, women had more frequent/intense heartburn and extra-oesophageal symptoms and more discomfort from abdominal pain, indigestion and constipation than men. Comorbid anxiety and depression may contribute to the increased symptom burden in women.

Keywords: Abdominal pain; extra-oesophageal symptoms; gastro-oesophageal reflux disease; gender differences; heartburn

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