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Li J, Orlin SE, Revere KE, et al. Acute onset anterior uveitis after darbepoetin alfa infusion. J Ophthalmic Inflamm Infect. 2015;5(1):31doi: 10.1186/s12348-015-0061-0.
Li, J., Orlin, S. E., Revere, K. E., & Kempen, J. H. (2015). Acute onset anterior uveitis after darbepoetin alfa infusion. Journal of ophthalmic inflammation and infection, 5(1), 31. https://doi.org/10.1186/s12348-015-0061-0
Li, Jonathan, et al. "Acute onset anterior uveitis after darbepoetin alfa infusion." Journal of ophthalmic inflammation and infection vol. 5,1 (2015): 31. doi: https://doi.org/10.1186/s12348-015-0061-0
Li J, Orlin SE, Revere KE, Kempen JH. Acute onset anterior uveitis after darbepoetin alfa infusion. J Ophthalmic Inflamm Infect. 2015 Dec;5(1):31. doi: 10.1186/s12348-015-0061-0. Epub 2015 Oct 26. PMID: 26502332; PMCID: PMC4621975.
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J Ophthalmic Inflamm Infect. 2015 Dec;5(1):31. doi: 10.1186/s12348-015-0061-0. Epub 2015 Oct 26.

Acute onset anterior uveitis after darbepoetin alfa infusion.

Journal of ophthalmic inflammation and infection

Jonathan Li, Stephen E Orlin, Karen E Revere, John H Kempen

Affiliations

  1. Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. [email protected].
  2. Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. [email protected].
  3. Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. [email protected].
  4. Department of Ophthalmology, Scheie Eye Institute, 51 N 39th St, Philadelphia, PA, 19104, USA. [email protected].
  5. Department of Biostatistics and Epidemiology, Philadelphia, PA, USA. [email protected].
  6. Center for Clinical Epidemiology and Biostatistics, the Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. [email protected].

PMID: 26502332 PMCID: PMC4621975 DOI: 10.1186/s12348-015-0061-0

Abstract

A 79-year-old female with a 2-month history of newly diagnosed myelodysplastic syndrome for which she received blood transfusion with darbepoetin alfa presented with bilateral anterior uveitis 1 day after her fourth transfusion. On exam, visual acuity was 20/20 in both eyes with biomicroscopy notable for conjunctival injection and anterior chamber cell and flare consistent with anterior uveitis. She had no systemic symptoms, no history of eye trauma, and no known infections. This case, along with prior reports in the literature, suggests that anterior uveitis may be an idiosyncratic complication of darbepoetin alfa therapy.

Keywords: Anterior uveitis; Darbepoetin; Erythropoietin; Iritis

References

  1. Br J Cancer. 2009 Mar 10;100(5):822-8 - PubMed
  2. Curr Opin Ophthalmol. 2013 Nov;24(6):589-97 - PubMed
  3. Clin Pharmacol Ther. 1981 Aug;30(2):239-45 - PubMed
  4. Ann Rheum Dis. 2003 Apr;62(4):378 - PubMed
  5. Drug Saf. 1997 Sep;17(3):197-207 - PubMed
  6. Eur J Ophthalmol. 1996 Jan-Mar;6(1):14-6 - PubMed
  7. J Clin Oncol. 2006 May 20;24(15):2233-6 - PubMed

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