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He XJ, Uchida K, Megumi C, et al. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. J Toxicol Pathol. 2015;28(4):197-206doi: 10.1293/tox.2015-0020.
He, X. J., Uchida, K., Megumi, C., Tsuge, N., & Nakayama, H. (2015). Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. Journal of toxicologic pathology, 28(4), 197-206. https://doi.org/10.1293/tox.2015-0020
He, Xi-Jun, et al. "Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice." Journal of toxicologic pathology vol. 28,4 (2015): 197-206. doi: https://doi.org/10.1293/tox.2015-0020
He XJ, Uchida K, Megumi C, Tsuge N, Nakayama H. Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice. J Toxicol Pathol. 2015 Oct;28(4):197-206. doi: 10.1293/tox.2015-0020. Epub 2015 Jul 27. PMID: 26538809; PMCID: PMC4604129.
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J Toxicol Pathol. 2015 Oct;28(4):197-206. doi: 10.1293/tox.2015-0020. Epub 2015 Jul 27.

Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice.

Journal of toxicologic pathology

Xi-Jun He, Kazuyuki Uchida, Chiaki Megumi, Nobuaki Tsuge, Hiroyuki Nakayama

Affiliations

  1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001 People's Republic of China ; Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi,Bunkyo-ku, Tokyo 113-8657, Japan.
  2. Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi,Bunkyo-ku, Tokyo 113-8657, Japan.
  3. Somatech Center, House Foods Corporation, 1-4 Takanodai, Yotsukaido, Chiba 284-0033, Japan.

PMID: 26538809 PMCID: PMC4604129 DOI: 10.1293/tox.2015-0020

Abstract

Studies in vivo and in vitro suggest that curcumin is a neuroprotective agent. Experiments were conducted to determine whether dietary supplementation with curcumin has neuroprotective effects in a mouse model of Parkinson's disease (PD). Treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) significantly induced the loss of dopaminergic cells in the substantia nigra and deletion of dopamine in the striatum, which was attenuated by long-term (7 weeks) dietary supplementation with curcumin at a concentration of 0.5% or 2.0% (w/w). Although curcumin did not prevent the MPTP-induced apoptosis of neuroblasts in the subventricular zone (SVZ), it promoted the regeneration of neuroblasts in the anterior part of the SVZ (SVZa) at 3 days after MPTP treatment. Furthermore, curcumin enhanced the MPTP-induced activation of microglia and astrocytes in the striatum and increased the expression of glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-β1 (TGFβ1) in the striatum and SVZ. GDNF and TGFβ1 are thought to play an important role in protecting neurons from injury in the central and peripheral nervous systems. These results suggest that long-term administration of curcumin blocks the neurotoxicity of MPTP in the nigrostriatal dopaminergic system of the mouse and that the neuroprotective effect might be correlated with the increased expression of GDNF and TGFβ1. Curcumin may be effective in preventing or slowing the progression of PD.

Keywords: MPTP; astrocyte; curcumin; dopamine; microglia; neuroprotective

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