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Monrad P, Sannagowdara K, Bozarth X, et al. Haemodynamic response associated with both ictal and interictal epileptiform activity using simultaneous video electroencephalography/near infrared spectroscopy in a within-subject study. J Near Infrared Spectrosc. 2015;23(4):209-218doi: 10.1255/jnirs.1170.
Monrad, P., Sannagowdara, K., Bozarth, X., Bhosrekar, S., Hecox, K., Nwosu, M., Schwabe, M., Meyer, M., Szabo, A., Prigge, J., Lemke, R., Horn, B., & Whelan, H. T. (2015). Haemodynamic response associated with both ictal and interictal epileptiform activity using simultaneous video electroencephalography/near infrared spectroscopy in a within-subject study. Journal of near infrared spectroscopy, 23(4), 209-218. https://doi.org/10.1255/jnirs.1170
Monrad, Priya, et al. "Haemodynamic response associated with both ictal and interictal epileptiform activity using simultaneous video electroencephalography/near infrared spectroscopy in a within-subject study." Journal of near infrared spectroscopy vol. 23,4 (2015): 209-218. doi: https://doi.org/10.1255/jnirs.1170
Monrad P, Sannagowdara K, Bozarth X, Bhosrekar S, Hecox K, Nwosu M, Schwabe M, Meyer M, Szabo A, Prigge J, Lemke R, Horn B, Whelan HT. Haemodynamic response associated with both ictal and interictal epileptiform activity using simultaneous video electroencephalography/near infrared spectroscopy in a within-subject study. J Near Infrared Spectrosc. 2015;23(4):209-218. doi: 10.1255/jnirs.1170. Epub 2015 Sep 24. PMID: 26538840; PMCID: PMC4629858.
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J Near Infrared Spectrosc. 2015;23(4):209-218. doi: 10.1255/jnirs.1170. Epub 2015 Sep 24.

Haemodynamic response associated with both ictal and interictal epileptiform activity using simultaneous video electroencephalography/near infrared spectroscopy in a within-subject study.

Journal of near infrared spectroscopy

Priya Monrad, Kumar Sannagowdara, Xiuhua Bozarth, Sugandha Bhosrekar, Kurt Hecox, Michelle Nwosu, Michael Schwabe, Michael Meyer, Aniko Szabo, Jenna Prigge, Russ Lemke, Briana Horn, Harry T Whelan

Affiliations

  1. Department of Neurology, Division of Child Neurology, Medical College of Wisconsin, WI, USA.
  2. Department of Pediatrics, Division of Pediatric Critical Care Medicine, Medical College of Wisconsin, WI, USA.

PMID: 26538840 PMCID: PMC4629858 DOI: 10.1255/jnirs.1170

Abstract

This paper reports the findings from a pilot study of four patients with medically refractory epilepsy undergoing pre-surgical evaluation with ages ranging from 5 to 17 years. Video electroencephalography recordings and data from a near infrared spectroscopy cerebral/somatic oximeter were gathered and related to electrographic seizure onset and offset as determined by a paediatric epileptologist. All four patients showed haemodynamic changes associated with epileptiform activities. The increased blood flow clearly coincided with epileptiform activity and continued to increase as the epileptiform activity built up. Regional cerebral oxygen saturation increased in the epileptogenic focus, perhaps due to loss of cerebrovascular autoregulation. These findings reinforce that near infrared spectroscopy can potentially be used in a wide spectrum of patients with epilepsy regardless of the underlying brain pathology.

Keywords: brain oxygen consumption; cerebrovascular autoregulation; electroencephalography; epilepsy; haemodynamic response; ictal; interictal; monitoring oxygen; near infrared spectroscopy; oxygen saturation; seizure

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