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Venning FA, Wullkopf L, Erler JT. Targeting ECM Disrupts Cancer Progression. Front Oncol. 2015;5:224doi: 10.3389/fonc.2015.00224.
Venning, F. A., Wullkopf, L., & Erler, J. T. (2015). Targeting ECM Disrupts Cancer Progression. Frontiers in oncology, 5224. https://doi.org/10.3389/fonc.2015.00224
Venning, Freja A, et al. "Targeting ECM Disrupts Cancer Progression." Frontiers in oncology vol. 5 (2015): 224. doi: https://doi.org/10.3389/fonc.2015.00224
Venning FA, Wullkopf L, Erler JT. Targeting ECM Disrupts Cancer Progression. Front Oncol. 2015 Oct 20;5:224. doi: 10.3389/fonc.2015.00224. eCollection 2015. PMID: 26539408; PMCID: PMC4611145.
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Front Oncol. 2015 Oct 20;5:224. doi: 10.3389/fonc.2015.00224. eCollection 2015.

Targeting ECM Disrupts Cancer Progression.

Frontiers in oncology

Freja A Venning, Lena Wullkopf, Janine T Erler

Affiliations

  1. Biotech Research and Innovation Centre (BRIC), University of Copenhagen (UCPH) , Copenhagen , Denmark.

PMID: 26539408 PMCID: PMC4611145 DOI: 10.3389/fonc.2015.00224

Abstract

Metastatic complications are responsible for more than 90% of cancer-related deaths. The progression from an isolated tumor to disseminated metastatic disease is a multistep process, with each step involving intricate cross talk between the cancer cells and their non-cellular surroundings, the extracellular matrix (ECM). Many ECM proteins are significantly deregulated during the progression of cancer, causing both biochemical and biomechanical changes that together promote the metastatic cascade. In this review, the influence of several ECM proteins on these multiple steps of cancer spread is summarized. In addition, we highlight the promising (pre-)clinical data showing benefits of targeting these ECM macromolecules to prevent cancer progression.

Keywords: collagen I; extracellular matrix; hyaluronan; metastasis; periostin; tenascin C

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