Display options
Cite
Casaer MP, Van den Berghe G. Editorial on the original article entitled "Permissive underfeeding of standard enteral feeding in critically ill adults" published in the New England Journal of Medicine on June 18, 2015. Ann Transl Med. 2015;3(16):226doi: 10.3978/j.issn.2305-5839.2015.07.22.
Casaer, M. P., & Van den Berghe, G. (2015). Editorial on the original article entitled "Permissive underfeeding of standard enteral feeding in critically ill adults" published in the New England Journal of Medicine on June 18, 2015. Annals of translational medicine, 3(16), 226. https://doi.org/10.3978/j.issn.2305-5839.2015.07.22
Casaer, Michael P, and Van den Berghe, Greet. "Editorial on the original article entitled "Permissive underfeeding of standard enteral feeding in critically ill adults" published in the New England Journal of Medicine on June 18, 2015." Annals of translational medicine vol. 3,16 (2015): 226. doi: https://doi.org/10.3978/j.issn.2305-5839.2015.07.22
Casaer MP, Van den Berghe G. Editorial on the original article entitled "Permissive underfeeding of standard enteral feeding in critically ill adults" published in the New England Journal of Medicine on June 18, 2015. Ann Transl Med. 2015 Sep;3(16):226. doi: 10.3978/j.issn.2305-5839.2015.07.22. PMID: 26539443; PMCID: PMC4598446.
Copy Download .nbib Format: NLM
Share it on

Ann Transl Med. 2015 Sep;3(16):226. doi: 10.3978/j.issn.2305-5839.2015.07.22.

Editorial on the original article entitled "Permissive underfeeding of standard enteral feeding in critically ill adults" published in the New England Journal of Medicine on June 18, 2015.

Annals of translational medicine

Michael P Casaer, Greet Van den Berghe

Affiliations

  1. Clinical Division and Laboratory of Intensive Care Medicine, Academic Department of Cellular and Molecular Medicine, Katholieke Universiteit Leuven, Leuven, Belgium.

PMID: 26539443 PMCID: PMC4598446 DOI: 10.3978/j.issn.2305-5839.2015.07.22

Abstract

On June 18, 2015, the New England Journal of Medicine published an article entitled "Permissive underfeeding of standard enteral feeding in critically ill adults", which reports the results of a study that examined the impact of prolonged nutritional energy restriction for critically ill patients. The study design was unique in the sense that patients in both groups received similar doses of protein during the intervention, while the non-protein energy intake was reduced in the intervention group. The study showed no differences in outcome between the two study groups. These results add to a growing body of high quality evidence against the dogmatic belief that full enteral or parenteral feeding should be given as early as possible during critical illness to prevent complications. Further research is now needed to address the question of the optimal timing to provide more nutritional support for the benefit of the patients, possibly guided by improved biomarkers that need to be developed and validated, and to investigate underlying mechanisms.

Keywords: Nutrition; autophagy; critical illness; hypocaloric feeding; isonitrogenous; renal replacement therapy

References

  1. J Am Soc Nephrol. 2013 May;24(6):995-1005 - PubMed
  2. JAMA. 2013 May 22;309(20):2130-8 - PubMed
  3. Crit Care Med. 2011 May;39(5):967-74 - PubMed
  4. Lancet Diabetes Endocrinol. 2015 Sep;3(9):734-45 - PubMed
  5. Nutrition. 2003 Nov-Dec;19(11-12):909-16 - PubMed
  6. Am J Pathol. 2014 May;184(5):1384-94 - PubMed
  7. Am J Clin Nutr. 2011 Mar;93(3):569-77 - PubMed
  8. Intensive Care Med. 2015 Jul;41(7):1197-208 - PubMed
  9. Crit Care. 2014 Apr 14;18(2):R72 - PubMed
  10. J Clin Endocrinol Metab. 2011 Apr;96(4):E633-45 - PubMed
  11. N Engl J Med. 2011 Apr 7;364(14):1293-304 - PubMed
  12. N Engl J Med. 2014 Mar 27;370(13):1227-36 - PubMed
  13. J Am Soc Nephrol. 2008 Mar;19(3):571-8 - PubMed
  14. N Engl J Med. 2015 Jun 18;372(25):2398-408 - PubMed
  15. Lancet Respir Med. 2013 Oct;1(8):621-9 - PubMed
  16. Crit Care Med. 2013 Oct;41(10):2298-309 - PubMed
  17. N Engl J Med. 2011 Aug 11;365(6):506-17 - PubMed
  18. JPEN J Parenter Enteral Nutr. 2002 May-Jun;26(3):174-81 - PubMed
  19. JAMA. 2012 Feb 22;307(8):795-803 - PubMed
  20. JAMA. 2008 Dec 17;300(23):2731-41 - PubMed
  21. Crit Care. 2013 Feb 01;17(1):302 - PubMed
  22. Crit Care Med. 2013 Jan;41(1):182-94 - PubMed
  23. Clin Nutr. 2014 Apr;33(2):246-51 - PubMed
  24. Am J Respir Crit Care Med. 2014 Aug 15;190(4):410-20 - PubMed
  25. JPEN J Parenter Enteral Nutr. 2012 Jan;36(1):60-8 - PubMed
  26. N Engl J Med. 2013 Apr 18;368(16):1489-97 - PubMed
  27. Intensive Care Med. 2009 Oct;35(10):1728-37 - PubMed
  28. Endocrinology. 2012 May;153(5):2267-76 - PubMed
  29. CMAJ. 2004 Jan 20;170(2):197-204 - PubMed
  30. Lancet. 2013 Feb 2;381(9864):385-93 - PubMed

Publication Types