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Neuroophthalmology. 2015;39(3):140-143. doi: 10.3109/01658107.2015.1011755. Epub 2015 May 13.

Alternating skew deviation in association with anti-glutamic acid decarboxylase antibodies.

Neuro-ophthalmology (Aeolus Press)

Asim V Farooq, Ketki Soin, Heather E Moss

Affiliations

  1. Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL.

PMID: 26594078 PMCID: PMC4460821 DOI: 10.3109/01658107.2015.1011755

Abstract

The presence of an elevated anti-glutamic acid decarboxylase (GAD) antibody level has been associated with a number of eye movement abnormalities, as well as other findings including cerebellar ataxia and insulin dependent diabetes mellitus. Skew deviation in association with anti-GAD antibodies has not been previously reported. Here we report a case of alternating skew deviation along with cerebellar-brainstem signs in a patient with an elevated anti-GAD antibody titer. Follow-up neurologic evaluation after treatment with intravenous immunoglobulin revealed improvement in cerebellar-brainstem signs, while ophthalmic evaluation was stable.

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